Prediction of Vagal Nerve Stimulation Efficacy in
Drug-Resistant Epilepsy (PRECISE): Prospective Study for
Pre-implantation Prediction/Study Design

J 2022

Prediction of Vagal Nerve Stimulation Efficacy in Drug-Resistant Epilepsy (PRECISE): Prospective Study for Pre-implantation Prediction/Study Design

DOLEŽALOVÁ, Irena, Eva KORIŤÁKOVÁ, Lenka SOUČKOVÁ, Jan CHRASTINA, Jan CHLÁDEK et. al.

Basic information

Original name

Prediction of Vagal Nerve Stimulation Efficacy in Drug-Resistant Epilepsy (PRECISE): Prospective Study for Pre-implantation Prediction/Study Design

Name in Czech

Predikce účinnosti vagové neurostimulace u farmakorezistentní epilepsie (PRECISE): Prospektivní studie pro předimplantační predikci/návrh studie

Authors

DOLEŽALOVÁ, Irena (203 Czech Republic, belonging to the institution), Eva KORIŤÁKOVÁ (203 Czech Republic, belonging to the institution), Lenka SOUČKOVÁ (203 Czech Republic, belonging to the institution), Jan CHRASTINA (203 Czech Republic, belonging to the institution), Jan CHLÁDEK (203 Czech Republic, belonging to the institution), Radka ŠTĚPÁNOVÁ (203 Czech Republic, belonging to the institution) and Milan BRÁZDIL (203 Czech Republic, guarantor, belonging to the institution)

Edition

FRONTIERS IN NEUROLOGY, LAUSANNE, FRONTIERS MEDIA SA, 2022, 1664-2295

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.400

RIV identification code

RIV/00216224:14110/22:00126798

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3389/fneur.2022.839163

UT WoS

000860449700001

Keywords in English

drug-resistant epilepsy; efficacy prediction; statistical model; study design; vagal nerve stimulation.

Abstract

V originále

Vagal nerve stimulation (VNS) can be indicated in patients with drug-resistant epilepsy, who are not eligible for resective epilepsy surgery. In VNS therapy, the responder rate (i.e., percentage of subjects experiencing ≥50% seizure reduction) is ~50%. At the moment, there is no widely-accepted possibility to predict VNS efficacy in a particular patient based on pre-implantation data, which can lead to unnecessary surgery and improper allocation of financial resources. The principal aim of PRediction of vagal nerve stimulation EfficaCy In drug-reSistant Epilepsy (PRECISE) study is to verify the predictability of VNS efficacy by analysis of pre-implantation routine electroencephalogram (EEG).

Links

CZ.02.1.01/0.0/0.0/16_013/0001826, interní kód MU
(CEP code: EF16_013/0001826)

Name: CZECRIN_PRO PACIENTY - zavádění inovativních moderních terapií

Investor: Ministry of Education, Youth and Sports of the CR, Priority axis 1: Strengthening capacities for high-quality research

LM2018128, research and development project

Name: Český národní uzel Evropské sítě infrastruktur klinického výzkumu (Acronym: CZECRIN)

Investor: Ministry of Education, Youth and Sports of the CR

NV19-04-00343, research and development project

Name: Predikce Efektu Stimulace u pacientů s Epilepsií (PRESEnCE) (Acronym: PRESEnCE)

Investor: Ministry of Health of the CR

Citovat

DOLEŽALOVÁ, Irena, Eva KORIŤÁKOVÁ, Lenka SOUČKOVÁ, Jan CHRASTINA, Jan CHLÁDEK, Radka ŠTĚPÁNOVÁ and Milan BRÁZDIL. Prediction of Vagal Nerve Stimulation Efficacy in Drug-Resistant Epilepsy (PRECISE): Prospective Study for Pre-implantation Prediction/Study Design. FRONTIERS IN NEUROLOGY. LAUSANNE: FRONTIERS MEDIA SA, 2022, vol. 13, March 2022, p. 1-9. ISSN 1664-2295. Available from: https://dx.doi.org/10.3389/fneur.2022.839163.

@article{2222185,
   author = {Doležalová, Irena and Koriťáková, Eva and Součková, Lenka and Chrastina, Jan and Chládek, Jan and Štěpánová, Radka and Brázdil, Milan},
   article_location = {LAUSANNE},
   article_number = {March 2022},
   doi = {http://dx.doi.org/10.3389/fneur.2022.839163},
   keywords = {drug-resistant epilepsy; efficacy prediction; statistical model; study design; vagal nerve stimulation.},
   language = {eng},
   issn = {1664-2295},
   journal = {FRONTIERS IN NEUROLOGY},
   title = {Prediction of Vagal Nerve Stimulation Efficacy in Drug-Resistant Epilepsy (PRECISE): Prospective Study for Pre-implantation Prediction/Study Design},
   url = {https://pubmed.ncbi.nlm.nih.gov/35386419/},
   volume = {13},
   year = {2022}
}

TY  - JOUR
ID  - 2222185
AU  - Doležalová, Irena - Koriťáková, Eva - Součková, Lenka - Chrastina, Jan - Chládek, Jan - Štěpánová, Radka - Brázdil, Milan
PY  - 2022
TI  - Prediction of Vagal Nerve Stimulation Efficacy in Drug-Resistant Epilepsy (PRECISE): Prospective Study for Pre-implantation Prediction/Study Design
JF  - FRONTIERS IN NEUROLOGY
VL  - 13
IS  - March 2022
SP  - 1-9
EP  - 1-9
PB  - FRONTIERS MEDIA SA
SN  - 16642295
KW  - drug-resistant epilepsy
KW  - efficacy prediction
KW  - statistical model
KW  - study design
KW  - vagal nerve stimulation.
UR  - https://pubmed.ncbi.nlm.nih.gov/35386419/
N2  - Vagal nerve stimulation (VNS) can be indicated in patients with drug-resistant epilepsy, who are not eligible for resective epilepsy surgery. In VNS therapy, the responder rate (i.e., percentage of subjects experiencing ≥50% seizure reduction) is ~50%. At the moment, there is no widely-accepted possibility to predict VNS efficacy in a particular patient based on pre-implantation data, which can lead to unnecessary surgery and improper allocation of financial resources. The principal aim of PRediction of vagal nerve stimulation EfficaCy In drug-reSistant Epilepsy (PRECISE) study is to verify the predictability of VNS efficacy by analysis of pre-implantation routine electroencephalogram (EEG).
ER  -

DOLEŽALOVÁ, Irena, Eva KORIŤÁKOVÁ, Lenka SOUČKOVÁ, Jan CHRASTINA, Jan CHLÁDEK, Radka ŠTĚPÁNOVÁ and Milan BRÁZDIL. Prediction of Vagal Nerve Stimulation Efficacy in Drug-Resistant Epilepsy (PRECISE): Prospective Study for Pre-implantation Prediction/Study Design. \textit{FRONTIERS IN NEUROLOGY}. LAUSANNE: FRONTIERS MEDIA SA, 2022, vol.~13, March 2022, p.~1-9. ISSN~1664-2295. Available from: https://dx.doi.org/10.3389/fneur.2022.839163.

Detailed Information on Publication Record