Background Public Health Guidelines (PHG) may be challenging to develop, due to complex interventions, especially from a population perspective, when targeting health systems, equity, environmental issues, health reforms, and policies, among others. Objective This review aims to determine how Grading of Recommendations Assessment, Development and Evaluation (GRADE) PHG have addressed previously identified challenges (identifying different stakeholders; incorporating their perspectives; prioritizing non-health outcomes; determining thresholds for decision-making; incorporating non-randomized studies; concerns with conditional recommendations) and what modifications were made to the GRADE approach. Methods We searched and title-screened GRADE PHG published in 2013-2021 applying a pre-defined protocol and JBI methods. We screened full texts of the identified documents and extracted information on the guideline methods. We used directed content analysis and descriptive statistics for data analysis.