Diagnostic Test Accuracy of Existing Practices Identifying Type 2 Pre Diabetes in Children A Systematic Review of Diagnostic Test Evidence

TUČKOVÁ, Dagmar, Abanoub RIAD, Simona SLEZÁKOVÁ and Miloslav KLUGAR. Diagnostic Test Accuracy of Existing Practices Identifying Type 2 Pre Diabetes in Children A Systematic Review of Diagnostic Test Evidence. In GIN 2022, Toronto. 2022.

Basic information

• Original name: Diagnostic Test Accuracy of Existing Practices Identifying Type 2 Pre Diabetes in Children A Systematic Review of Diagnostic Test Evidence
• Authors: TUČKOVÁ, Dagmar, Abanoub RIAD, Simona SLEZÁKOVÁ and Miloslav KLUGAR.
• Edition: GIN 2022, Toronto, 2022.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 30202 Endocrinology and metabolism
• Country of publisher: Canada
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Organization unit: Faculty of Medicine
• Keywords in English: diabetes; diagnostic test accuracy

Abstract

Background 422 million people worldwide have diabetes. In 2019, diabetes was direct of 1.5 million deaths. Between 2000 and 2016, there was a 5% increase in premature mortality from diabetes. The need for a practical, accurate diagnostic test for pediatric patients is great due to the epidemic of childhood obesity in developed countries. Objective Systematic review objective was to identify all alternative tests currently in use for the diagnosis of type 2 pre-diabetes in children and establish their accuracy relative to gold standard. Methods We followed JBI methodology for systematic review of diagnostic test accuracy (DTA SR). Threephases search strategy was used. Two independent reviewers screened, critically appraised, extracted and synthesized data. We performed meta-analyses for sensitivity and specificity of diagnostic tests. SROC (Summary receiver operating curve) plot of tests was utilized as well. Results Total number of four studies was possible to be pooled in the meta-analyses. SR DTA provided evidence of the accuracy: FPG ≥7.0 mmol/L versus OGTT in two studies in two different populations. Three diagnostic tests are recommended for a practice (FPG ≥7.0 mmol/l versus OGTT, HbA1c 6.5 % versus OGTT, and TG_HDL 1.71 mmol/L versus HOMA-IR). Discussion Based on results, it can be further discussed how important predictor is ethnicity and ontogenetic development in determining of cut off points.