Preparation and evaluation of spray-dried microparticles
containing N-acetylcysteine for lung application

a 2022

Preparation and evaluation of spray-dried microparticles containing N-acetylcysteine for lung application

HOŘAVOVÁ, Hana and Jan GAJDZIOK

Basic information

Original name

Preparation and evaluation of spray-dried microparticles containing N-acetylcysteine for lung application

Authors

HOŘAVOVÁ, Hana (203 Czech Republic, belonging to the institution) and Jan GAJDZIOK (203 Czech Republic, belonging to the institution)

Edition

9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts, 2022

Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

odkaz na pdf verzi "book of abstracts"

RIV identification code

RIV/00216224:14160/22:00126880

Organization unit

Faculty of Pharmacy

ISBN

978-961-94230-4-2

Keywords in English

N-acetylcysteine; spray drying; lung aplication; microparticles

Abstract

V originále

In this paper, the author's aim was to develop a dry powder formulation of mucolytic N-acetylcysteine (NAC) intended for inhalation. As a method of preparation, spray drying was chosen. It was confirmed that spray drying of NAC is problematic due to its high hygroscopicity and low glass transition temperature (Tg). Different excipients were applied in order to enhance the powder performance - sodium hydroxide (salt formation and reduction of hygroscopicity), dextran or maltodextrin (reduction of Tg), chitosan (encapsulation), and leucine (reduction of hygroscopicity, anti-adherent). Every approach led to spherical particles, but only increasing the content of leucine generated separated particles showing the best results in 20-25 % of solid content. However, further research is needed to decrease particle size.

Links

MUNI/A/1140/2021, interní kód MU

Name: Optimalizace porozity mikročástic pro plicní aplikaci (Acronym: porogeny)

Investor: Masaryk University

MUNI/A/1213/2020, interní kód MU

Name: Formulace a hodnocení depozice mikročásticových systémů k aplikaci do plic. (Acronym: plicní mikročástice)

Investor: Masaryk University

Citovat

HOŘAVOVÁ, Hana and Jan GAJDZIOK. Preparation and evaluation of spray-dried microparticles containing N-acetylcysteine for lung application. In 9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts. 2022. ISBN 978-961-94230-4-2.

@proceedings{2224538,
   author = {Hořavová, Hana and Gajdziok, Jan},
   booktitle = {9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts},
   keywords = {N-acetylcysteine; spray drying; lung aplication; microparticles},
   language = {eng},
   isbn = {978-961-94230-4-2},
   title = {Preparation and evaluation of spray-dried microparticles containing N-acetylcysteine for lung application},
   url = {https://bbbb2022.sfd.si/wp-content/uploads/2020/08/9th-bbbb-conference-book-of-abstracts.pdf},
   year = {2022}
}

TY  - CONF
ID  - 2224538
AU  - Hořavová, Hana - Gajdziok, Jan
PY  - 2022
TI  - Preparation and evaluation of spray-dried microparticles containing N-acetylcysteine for lung application
SN  - 9789619423042
KW  - N-acetylcysteine
KW  - spray drying
KW  - lung aplication
KW  - microparticles
UR  - https://bbbb2022.sfd.si/wp-content/uploads/2020/08/9th-bbbb-conference-book-of-abstracts.pdf
N2  - In this paper, the author's aim was to develop a dry powder formulation of mucolytic N-acetylcysteine (NAC) intended for inhalation. As a method of preparation, spray drying was chosen. It was confirmed that spray drying of NAC is problematic due to its high hygroscopicity and low glass transition temperature (Tg). Different excipients were applied in order to enhance the powder performance - sodium hydroxide (salt formation and reduction of hygroscopicity), dextran or maltodextrin (reduction of Tg), chitosan (encapsulation), and leucine (reduction of hygroscopicity, anti-adherent). Every approach led to spherical particles, but only increasing the content of leucine generated separated particles showing the best results in 20-25 % of solid content. However, further research is needed to decrease particle size.
ER  -

HOŘAVOVÁ, Hana and Jan GAJDZIOK. Preparation and evaluation of spray-dried microparticles containing N-acetylcysteine for lung application. In \textit{9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts}. 2022. ISBN~978-961-94230-4-2.

Detailed Information on Publication Record