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@proceedings{2224538,
author = {Hořavová, Hana and Gajdziok, Jan},
booktitle = {9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts},
keywords = {N-acetylcysteine; spray drying; lung aplication; microparticles},
language = {eng},
isbn = {978-961-94230-4-2},
title = {Preparation and evaluation of spray-dried microparticles containing N-acetylcysteine for lung application},
url = {https://bbbb2022.sfd.si/wp-content/uploads/2020/08/9th-bbbb-conference-book-of-abstracts.pdf},
year = {2022}
}
TY - CONF
ID - 2224538
AU - Hořavová, Hana - Gajdziok, Jan
PY - 2022
TI - Preparation and evaluation of spray-dried microparticles containing N-acetylcysteine for lung application
SN - 9789619423042
KW - N-acetylcysteine
KW - spray drying
KW - lung aplication
KW - microparticles
UR - https://bbbb2022.sfd.si/wp-content/uploads/2020/08/9th-bbbb-conference-book-of-abstracts.pdf
N2 - In this paper, the author's aim was to develop a dry powder formulation of mucolytic N-acetylcysteine (NAC) intended for inhalation. As a method of preparation, spray drying was chosen. It was confirmed that spray drying of NAC is problematic due to its high hygroscopicity and low glass transition temperature (Tg). Different excipients were applied in order to enhance the powder performance - sodium hydroxide (salt formation and reduction of hygroscopicity), dextran or maltodextrin (reduction of Tg), chitosan (encapsulation), and leucine (reduction of hygroscopicity, anti-adherent). Every approach led to spherical particles, but only increasing the content of leucine generated separated particles showing the best results in 20-25 % of solid content. However, further research is needed to decrease particle size.
ER -
HOŘAVOVÁ, Hana and Jan GAJDZIOK. Preparation and evaluation of spray-dried microparticles containing N-acetylcysteine for lung application. In \textit{9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts}. 2022. ISBN~978-961-94230-4-2.
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