Detailed Information on Publication Record
2022
Preparation and evaluation of spray-dried microparticles containing colistin or liposomes
HOŘAVOVÁ, Hana, Jan GAJDZIOK and Kristína MOLNÁROVÁBasic information
Original name
Preparation and evaluation of spray-dried microparticles containing colistin or liposomes
Authors
HOŘAVOVÁ, Hana (203 Czech Republic, belonging to the institution), Jan GAJDZIOK (203 Czech Republic, belonging to the institution) and Kristína MOLNÁROVÁ (703 Slovakia, belonging to the institution)
Edition
Student scientific conference MUNI PHARM 2022, 2022
Other information
Language
English
Type of outcome
Prezentace na konferencích
Field of Study
30104 Pharmacology and pharmacy
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
RIV identification code
RIV/00216224:14160/22:00126882
Organization unit
Faculty of Pharmacy
ISBN
978-80-280-0105-6
Keywords in English
colistin; liposomes; spray drying; microparticles
Tags
Změněno: 18/10/2022 14:46, PharmDr. Hana Hořavová
Abstract
V originále
In this study, a formulation containing the antibacterial agent colistin for lung application was prepared using different input spray drying parameters (temperature, dispersion or ingredient concentration, nozzle size). In the second part, the incorporation of liposomes (as a potential carrier for colistin) into the microparticles and their stability after the drying process were evaluated. The results show the best properties with a high leucine concentration, dilution of input dispersion, and high drying temperature. Compositions used for liposome batches were not completely effective in stabilizing vesicles during spray drying. However, increasing the concentration of mannitol protectant shows promising results, and the findings obtained are of great importance for further optimization.
Links
| MUNI/A/1213/2020, interní kód MU |
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| MUNI/A/1574/2020, interní kód MU |
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