Detailed Information on Publication Record
2020
CDK12: cellular functions and therapeutic potential of versatile player in cancer
PILAŘOVÁ, Květa, Jan HERUDEK and Dalibor BLAŽEKBasic information
Original name
CDK12: cellular functions and therapeutic potential of versatile player in cancer
Authors
Edition
NAR Cancer, 2020, 2632-8674
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
10608 Biochemistry and molecular biology
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Organization unit
Central European Institute of Technology
Tags
International impact, Reviewed
Změněno: 13/10/2022 19:07, Mgr. Pavla Foltynová, Ph.D.
Abstract
V originále
Cyclin-dependent kinase 12 (CDK12) phosphorylates the C-terminal domain of RNA polymerase II and is needed for the optimal transcription elongation and translation of a subset of human protein-coding genes. The kinase has a pleiotropic effect on the maintenance of genome stability, and its inactivation in prostate and ovarian tumours results in focal tandem duplications, a CDK12-unique genome instability phenotype. CDK12 aberrations were found in many other malignancies and have the potential to be used as biomarkers for therapeutic intervention. Moreover, the inhibition of CDK12 emerges as a promising strategy for treatment in several types of cancers. In this review, we summarize mechanisms that CDK12 utilizes for the regulation of gene expression and discuss how the perturbation of CDK12-sensitive genes contributes to the disruption of cell cycle progression and the onset of genome instability. Furthermore, we describe tumour-suppressive and oncogenic functions of CDK12 and its potential as a biomarker and inhibition target in anti-tumour treatments.
Links
| GA17-13692S, research and development project |
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