Self-Reported Overall Adherence and Correct Inhalation
Technique Discordance in Chronic Obstructive Pulmonary Disease
Population

J 2022

Self-Reported Overall Adherence and Correct Inhalation Technique Discordance in Chronic Obstructive Pulmonary Disease Population

HENDRYCHOVA, Tereza, Michal SVOBODA, Josef MALY, Jiri VLCEK, Eva ZIMCIKOVA et. al.

Basic information

Original name

Self-Reported Overall Adherence and Correct Inhalation Technique Discordance in Chronic Obstructive Pulmonary Disease Population

Authors

HENDRYCHOVA, Tereza (203 Czech Republic), Michal SVOBODA (203 Czech Republic), Josef MALY (203 Czech Republic), Jiri VLCEK (203 Czech Republic), Eva ZIMCIKOVA (203 Czech Republic), Tomas DVORAK (203 Czech Republic), Jaromir ZATLOUKAL (203 Czech Republic), Eva VOLAKOVA (203 Czech Republic), Marek PLUTINSKÝ (703 Slovakia, belonging to the institution), Kristián BRAT (703 Slovakia, belonging to the institution), Patrice POPELKOVA (203 Czech Republic), Michal KOPECKY (203 Czech Republic), Barbora NOVOTNA (203 Czech Republic) and Vladimir KOBLIZEK (203 Czech Republic, guarantor)

Edition

FRONTIERS IN PHARMACOLOGY, LAUSANNE, FRONTIERS MEDIA SA, 2022, 1663-9812

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30203 Respiratory systems

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.600

RIV identification code

RIV/00216224:14110/22:00126931

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3389/fphar.2022.860270

UT WoS

000844937200001

Keywords in English

COPD; adherence; compliance; application technique; inhalation systems

Abstract

V originále

Background: Adherence to inhaled medication constitutes a major problem in patients with chronic obstructive pulmonary disease (COPD) globally. However, large studies evaluating adherence in its entirety and capturing a large variety of potentially associated factors are still lacking.Objective: To study both elementary types of adherence to chronic inhaled COPD medication in "real-life" COPD patients and to assess relationships with a wide-ranging spectrum of clinical parameters.Methods: Data from the Czech Multicentre Research Database (CMRD) of COPD, an observational prospective study, were used. Overall adherence (OA) was evaluated with Morisky Medication Adherence Scale ((c) MMAS-4) and adherence to an application technique (A-ApplT) with the Five Steps Assessment. Mann-Whitney U test, Spearman's correlation, and logistic regression were used to explore relationships between variables.Results: Data of 546 participants (69.6% of all patients from the CMRD) were analyzed. Two-thirds self-reported optimal OA, but only less than one-third demonstrated A-ApplT without any error. OA did not correlate with A-ApplT. Next, better OA was associated with higher education, a higher number of inhalers, a lower rate of exacerbations, poorer lung function, higher degree of upper respiratory tract symptoms (SNOT-22), absence of depressive symptoms, ex-smoking status, regular mouthwash after inhaled corticosteroids (ICS), and flu vaccination. By contrast, better A-ApplT was associated with a lower number of inhalers, better lung function, and regular mouthwash after ICS. Independent predictors of nonoptimal OA included lower degree of education, absence of flu vaccination, anemia, depression, and peptic ulcer history, whereas independent predictors of lower A-ApplT were lower education, absence of regular mouthwash after ICS, and higher COPD Assessment Test score.Conclusions: Parameters associated with OA and A-ApplT differ, and those associated with both adherence domains are sometimes associated inversely. Based on this finding, we understand these as two separate constructs with an overlap.

Links

LM2018128, research and development project

Name: Český národní uzel Evropské sítě infrastruktur klinického výzkumu (Acronym: CZECRIN)

Investor: Ministry of Education, Youth and Sports of the CR

15/14/NAP, interní kód MU

Name: Sledování výskytu deficitu alfa 1 antitrypsinu u pacientů s těžkou formou CHOPN

Investor: Ministry of Health of the CR

5/15/NAP, interní kód MU

Name: Diagnostika bronchogenního karcinomu u nemocných s těžkou formou CHOPN pomocí výpočetní tomografie

Investor: Ministry of Health of the CR

Citovat

HENDRYCHOVA, Tereza, Michal SVOBODA, Josef MALY, Jiri VLCEK, Eva ZIMCIKOVA, Tomas DVORAK, Jaromir ZATLOUKAL, Eva VOLAKOVA, Marek PLUTINSKÝ, Kristián BRAT, Patrice POPELKOVA, Michal KOPECKY, Barbora NOVOTNA and Vladimir KOBLIZEK. Self-Reported Overall Adherence and Correct Inhalation Technique Discordance in Chronic Obstructive Pulmonary Disease Population. FRONTIERS IN PHARMACOLOGY. LAUSANNE: FRONTIERS MEDIA SA, 2022, vol. 13, August 2022, p. 1-11. ISSN 1663-9812. Available from: https://dx.doi.org/10.3389/fphar.2022.860270.

@article{2225479,
   author = {Hendrychova, Tereza and Svoboda, Michal and Maly, Josef and Vlcek, Jiri and Zimcikova, Eva and Dvorak, Tomas and Zatloukal, Jaromir and Volakova, Eva and Plutinský, Marek and Brat, Kristián and Popelkova, Patrice and Kopecky, Michal and Novotna, Barbora and Koblizek, Vladimir},
   article_location = {LAUSANNE},
   article_number = {August 2022},
   doi = {http://dx.doi.org/10.3389/fphar.2022.860270},
   keywords = {COPD; adherence; compliance; application technique; inhalation systems},
   language = {eng},
   issn = {1663-9812},
   journal = {FRONTIERS IN PHARMACOLOGY},
   title = {Self-Reported Overall Adherence and Correct Inhalation Technique Discordance in Chronic Obstructive Pulmonary Disease Population},
   url = {https://www.frontiersin.org/articles/10.3389/fphar.2022.860270/full},
   volume = {13},
   year = {2022}
}

TY  - JOUR
ID  - 2225479
AU  - Hendrychova, Tereza - Svoboda, Michal - Maly, Josef - Vlcek, Jiri - Zimcikova, Eva - Dvorak, Tomas - Zatloukal, Jaromir - Volakova, Eva - Plutinský, Marek - Brat, Kristián - Popelkova, Patrice - Kopecky, Michal - Novotna, Barbora - Koblizek, Vladimir
PY  - 2022
TI  - Self-Reported Overall Adherence and Correct Inhalation Technique Discordance in Chronic Obstructive Pulmonary Disease Population
JF  - FRONTIERS IN PHARMACOLOGY
VL  - 13
IS  - August 2022
SP  - 1-11
EP  - 1-11
PB  - FRONTIERS MEDIA SA
SN  - 16639812
KW  - COPD
KW  - adherence
KW  - compliance
KW  - application technique
KW  - inhalation systems
UR  - https://www.frontiersin.org/articles/10.3389/fphar.2022.860270/full
N2  - Background: Adherence to inhaled medication constitutes a major problem in patients with chronic obstructive pulmonary disease (COPD) globally. However, large studies evaluating adherence in its entirety and capturing a large variety of potentially associated factors are still lacking.Objective: To study both elementary types of adherence to chronic inhaled COPD medication in "real-life" COPD patients and to assess relationships with a wide-ranging spectrum of clinical parameters.Methods: Data from the Czech Multicentre Research Database (CMRD) of COPD, an observational prospective study, were used. Overall adherence (OA) was evaluated with Morisky Medication Adherence Scale ((c) MMAS-4) and adherence to an application technique (A-ApplT) with the Five Steps Assessment. Mann-Whitney U test, Spearman's correlation, and logistic regression were used to explore relationships between variables.Results: Data of 546 participants (69.6% of all patients from the CMRD) were analyzed. Two-thirds self-reported optimal OA, but only less than one-third demonstrated A-ApplT without any error. OA did not correlate with A-ApplT. Next, better OA was associated with higher education, a higher number of inhalers, a lower rate of exacerbations, poorer lung function, higher degree of upper respiratory tract symptoms (SNOT-22), absence of depressive symptoms, ex-smoking status, regular mouthwash after inhaled corticosteroids (ICS), and flu vaccination. By contrast, better A-ApplT was associated with a lower number of inhalers, better lung function, and regular mouthwash after ICS. Independent predictors of nonoptimal OA included lower degree of education, absence of flu vaccination, anemia, depression, and peptic ulcer history, whereas independent predictors of lower A-ApplT were lower education, absence of regular mouthwash after ICS, and higher COPD Assessment Test score.Conclusions: Parameters associated with OA and A-ApplT differ, and those associated with both adherence domains are sometimes associated inversely. Based on this finding, we understand these as two separate constructs with an overlap.
ER  -

HENDRYCHOVA, Tereza, Michal SVOBODA, Josef MALY, Jiri VLCEK, Eva ZIMCIKOVA, Tomas DVORAK, Jaromir ZATLOUKAL, Eva VOLAKOVA, Marek PLUTINSKÝ, Kristián BRAT, Patrice POPELKOVA, Michal KOPECKY, Barbora NOVOTNA and Vladimir KOBLIZEK. Self-Reported Overall Adherence and Correct Inhalation Technique Discordance in Chronic Obstructive Pulmonary Disease Population. \textit{FRONTIERS IN PHARMACOLOGY}. LAUSANNE: FRONTIERS MEDIA SA, 2022, vol.~13, August 2022, p.~1-11. ISSN~1663-9812. Available from: https://dx.doi.org/10.3389/fphar.2022.860270.

Detailed Information on Publication Record