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@article{2225479,
author = {Hendrychova, Tereza and Svoboda, Michal and Maly, Josef and Vlcek, Jiri and Zimcikova, Eva and Dvorak, Tomas and Zatloukal, Jaromir and Volakova, Eva and Plutinský, Marek and Brat, Kristián and Popelkova, Patrice and Kopecky, Michal and Novotna, Barbora and Koblizek, Vladimir},
article_location = {LAUSANNE},
article_number = {August 2022},
doi = {http://dx.doi.org/10.3389/fphar.2022.860270},
keywords = {COPD; adherence; compliance; application technique; inhalation systems},
language = {eng},
issn = {1663-9812},
journal = {FRONTIERS IN PHARMACOLOGY},
title = {Self-Reported Overall Adherence and Correct Inhalation Technique Discordance in Chronic Obstructive Pulmonary Disease Population},
url = {https://www.frontiersin.org/articles/10.3389/fphar.2022.860270/full},
volume = {13},
year = {2022}
}
TY - JOUR
ID - 2225479
AU - Hendrychova, Tereza - Svoboda, Michal - Maly, Josef - Vlcek, Jiri - Zimcikova, Eva - Dvorak, Tomas - Zatloukal, Jaromir - Volakova, Eva - Plutinský, Marek - Brat, Kristián - Popelkova, Patrice - Kopecky, Michal - Novotna, Barbora - Koblizek, Vladimir
PY - 2022
TI - Self-Reported Overall Adherence and Correct Inhalation Technique Discordance in Chronic Obstructive Pulmonary Disease Population
JF - FRONTIERS IN PHARMACOLOGY
VL - 13
IS - August 2022
SP - 1-11
EP - 1-11
PB - FRONTIERS MEDIA SA
SN - 16639812
KW - COPD
KW - adherence
KW - compliance
KW - application technique
KW - inhalation systems
UR - https://www.frontiersin.org/articles/10.3389/fphar.2022.860270/full
N2 - Background: Adherence to inhaled medication constitutes a major problem in patients with chronic obstructive pulmonary disease (COPD) globally. However, large studies evaluating adherence in its entirety and capturing a large variety of potentially associated factors are still lacking.Objective: To study both elementary types of adherence to chronic inhaled COPD medication in "real-life" COPD patients and to assess relationships with a wide-ranging spectrum of clinical parameters.Methods: Data from the Czech Multicentre Research Database (CMRD) of COPD, an observational prospective study, were used. Overall adherence (OA) was evaluated with Morisky Medication Adherence Scale ((c) MMAS-4) and adherence to an application technique (A-ApplT) with the Five Steps Assessment. Mann-Whitney U test, Spearman's correlation, and logistic regression were used to explore relationships between variables.Results: Data of 546 participants (69.6% of all patients from the CMRD) were analyzed. Two-thirds self-reported optimal OA, but only less than one-third demonstrated A-ApplT without any error. OA did not correlate with A-ApplT. Next, better OA was associated with higher education, a higher number of inhalers, a lower rate of exacerbations, poorer lung function, higher degree of upper respiratory tract symptoms (SNOT-22), absence of depressive symptoms, ex-smoking status, regular mouthwash after inhaled corticosteroids (ICS), and flu vaccination. By contrast, better A-ApplT was associated with a lower number of inhalers, better lung function, and regular mouthwash after ICS. Independent predictors of nonoptimal OA included lower degree of education, absence of flu vaccination, anemia, depression, and peptic ulcer history, whereas independent predictors of lower A-ApplT were lower education, absence of regular mouthwash after ICS, and higher COPD Assessment Test score.Conclusions: Parameters associated with OA and A-ApplT differ, and those associated with both adherence domains are sometimes associated inversely. Based on this finding, we understand these as two separate constructs with an overlap.
ER -
HENDRYCHOVA, Tereza, Michal SVOBODA, Josef MALY, Jiri VLCEK, Eva ZIMCIKOVA, Tomas DVORAK, Jaromir ZATLOUKAL, Eva VOLAKOVA, Marek PLUTINSKÝ, Kristián BRAT, Patrice POPELKOVA, Michal KOPECKY, Barbora NOVOTNA and Vladimir KOBLIZEK. Self-Reported Overall Adherence and Correct Inhalation Technique Discordance in Chronic Obstructive Pulmonary Disease Population. \textit{FRONTIERS IN PHARMACOLOGY}. LAUSANNE: FRONTIERS MEDIA SA, 2022, vol.~13, August 2022, p.~1-11. ISSN~1663-9812. Available from: https://dx.doi.org/10.3389/fphar.2022.860270.
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