Detailed Information on Publication Record
2021
Preparation of spray-dried microparticles containing N-acetylcysteine for lung application
HOŘAVOVÁ, Hana and Jan GAJDZIOKBasic information
Original name
Preparation of spray-dried microparticles containing N-acetylcysteine for lung application
Authors
HOŘAVOVÁ, Hana (203 Czech Republic, belonging to the institution) and Jan GAJDZIOK (203 Czech Republic, belonging to the institution)
Edition
Student scientific conference MUNI PHARM 2021, 2021
Other information
Language
English
Type of outcome
Prezentace na konferencích
Field of Study
30104 Pharmacology and pharmacy
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
RIV identification code
RIV/00216224:14160/21:00126946
Organization unit
Faculty of Pharmacy
ISBN
978-80-210-9870-1
Keywords in English
N-acetylcysteine; spray drying; lung aplication; microparticles
Tags
Změněno: 18/10/2022 14:57, PharmDr. Hana Hořavová
Abstract
V originále
In this paper, the author's aim was to develop a dry powder formulation of mucolytic N-acetylcysteine (NAC) intended for inhalation in mannitol carrier and with the addition of leucine as anti-adherent. As a method of preparation, spray drying was chosen. It was confirmed that spray drying of NAC is problematic due to its high hygroscopicity and low glass transition temperature (Tg). Different excipients were applied in order to enhance the powder performance - sodium hydroxide (salt formation and reduction of hygroscopicity), dextran or maltodextrin (reduction of Tg), and chitosan (encapsulation). Every approach led to spherical particles, but not individually separated and of the desired size. The results represent a reasonable basis for further development.
Links
| MUNI/A/1213/2020, interní kód MU |
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