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@proceedings{2225677,
author = {Hořavová, Hana and Gajdziok, Jan},
booktitle = {Student scientific conference MUNI PHARM 2021},
keywords = {N-acetylcysteine; spray drying; lung aplication; microparticles},
language = {eng},
isbn = {978-80-210-9870-1},
title = {Preparation of spray-dried microparticles containing N-acetylcysteine for lung application},
url = {https://munispace.muni.cz/library/catalog/book/1984?fbclid=IwAR21tjHoFJ6YKyAm7QhFgrJnyUUaCZVWGZYeO0VL4_HxPWtKRUX56zMVNSI},
year = {2021}
}
TY - CONF
ID - 2225677
AU - Hořavová, Hana - Gajdziok, Jan
PY - 2021
TI - Preparation of spray-dried microparticles containing N-acetylcysteine for lung application
SN - 9788021098701
KW - N-acetylcysteine
KW - spray drying
KW - lung aplication
KW - microparticles
UR - https://munispace.muni.cz/library/catalog/book/1984?fbclid=IwAR21tjHoFJ6YKyAm7QhFgrJnyUUaCZVWGZYeO0VL4_HxPWtKRUX56zMVNSI
N2 - In this paper, the author's aim was to develop a dry powder formulation of mucolytic N-acetylcysteine (NAC) intended for inhalation in mannitol carrier and with the addition of leucine as anti-adherent. As a method of preparation, spray drying was chosen. It was confirmed that spray drying of NAC is problematic due to its high hygroscopicity and low glass transition temperature (Tg). Different excipients were applied in order to enhance the powder performance - sodium hydroxide (salt formation and reduction of hygroscopicity), dextran or maltodextrin (reduction of Tg), and chitosan (encapsulation). Every approach led to spherical particles, but not individually separated and of the desired size. The results represent a reasonable basis for further development.
ER -
HOŘAVOVÁ, Hana and Jan GAJDZIOK. Preparation of spray-dried microparticles containing N-acetylcysteine for lung application. In \textit{Student scientific conference MUNI PHARM 2021}. 2021. ISBN~978-80-210-9870-1.
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