| HÁJKOVÁ, Monika, Tomáš ANDRAŠINA, Petra OVESNÁ, Tomáš ROHAN, Marek DOSTÁL, Vlastimil VÁLEK, Lenka OSTŘÍŽKOVÁ, Štěpán TUČEK, Jiří ŠEDO and Igor KISS. Volumetric Analysis of Hepatocellular Carcinoma After Transarterial Chemoembolization and its Impact on Overall Survival. In vivo. KAPANDRITI: International Institute of Anticancer Research, 2022, vol. 36, No 5, p. 2332-2341. ISSN 0258-851X. Available from: https://dx.doi.org/10.21873/invivo.12964. |
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@article{2228302,
author = {Hájková, Monika and Andrašina, Tomáš and Ovesná, Petra and Rohan, Tomáš and Dostál, Marek and Válek, Vlastimil and Ostřížková, Lenka and Tuček, Štěpán and Šedo, Jiří and Kiss, Igor},
article_location = {KAPANDRITI},
article_number = {5},
doi = {http://dx.doi.org/10.21873/invivo.12964},
keywords = {Hepatocellular carcinoma; transarterial chemoembolization; RECIST; mRECIST; volumetric analysis},
language = {eng},
issn = {0258-851X},
journal = {In vivo},
title = {Volumetric Analysis of Hepatocellular Carcinoma After Transarterial Chemoembolization and its Impact on Overall Survival.},
url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463903/},
volume = {36},
year = {2022}
}
TY - JOUR
ID - 2228302
AU - Hájková, Monika - Andrašina, Tomáš - Ovesná, Petra - Rohan, Tomáš - Dostál, Marek - Válek, Vlastimil - Ostřížková, Lenka - Tuček, Štěpán - Šedo, Jiří - Kiss, Igor
PY - 2022
TI - Volumetric Analysis of Hepatocellular Carcinoma After Transarterial Chemoembolization and its Impact on Overall Survival.
JF - In vivo
VL - 36
IS - 5
SP - 2332-2341
EP - 2332-2341
PB - International Institute of Anticancer Research
SN - 0258851X
KW - Hepatocellular carcinoma
KW - transarterial chemoembolization
KW - RECIST
KW - mRECIST
KW - volumetric analysis
UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463903/
N2 - Background/Aim: To evaluate the prognostic value of Response Evaluation Criteria In Solid Tumors (RECIST), modified RECIST and volumetric analysis in patients with hepatocellular carcinoma (HCC) treated by transarterial chemoembolization (TACE). Patients and Methods: This single-center prospective cohort study included a total of 61 patients with HCC treated by transarterial chemoembolization (TACE). The response of TACE was evaluated on preprocedural and postprocedural CT by two radiologists using RECIST/mRECIST and volumetric response to treatment. Each response assessment method was used to classify the response as progressive disease, stable disease, partial response and complete response. Kaplan-Meier analysis with log-rank test was performed for each method to evaluate its ability to help predict overall survival and progression free survival. Interobserver variability and reproducibility was determined by the Pearson and Spearman correlation coefficients. Results: The median overall survival was 17.1 months and the median progression-free survival was 11.1 months. Volumetric assessment was proved to be a prognostic factor for overall survival (p<0.01) and progression-free survival (p<0.001), contrasting with RECIST and mRECIST. All three methods featured very small interobserver variability (p<0.001 for Pearson and Spearman correlation coefficients). The patients classified as having stable disease had a 3.8-fold higher risk of death than the patients classified as having a complete/partial response (HR=3.82; 95% Confidence Interval (CI)=1.32-11.02; p=0.013) and a 4.5-fold higher risk of progression (HR=4.46; 95% CI=1.72-11.61; p=0.002). Conclusion: The prognostic value of volumetric analysis in patients with HCC treated by TACE appears to be superior to RECIST and mRECIST, with a real impact in everyday practice.
ER -
HÁJKOVÁ, Monika, Tomáš ANDRAŠINA, Petra OVESNÁ, Tomáš ROHAN, Marek DOSTÁL, Vlastimil VÁLEK, Lenka OSTŘÍŽKOVÁ, Štěpán TUČEK, Jiří ŠEDO and Igor KISS. Volumetric Analysis of Hepatocellular Carcinoma After Transarterial Chemoembolization and its Impact on Overall Survival. \textit{In vivo}. KAPANDRITI: International Institute of Anticancer Research, 2022, vol.~36, No~5, p.~2332-2341. ISSN~0258-851X. Available from: https://dx.doi.org/10.21873/invivo.12964.
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