Comparison of Patients with Reduced and Mildly Reduced Left
Ventricular Ejection Fraction: Intermediate Data from the FAR
NHL Registry

J 2022

Comparison of Patients with Reduced and Mildly Reduced Left Ventricular Ejection Fraction: Intermediate Data from the FAR NHL Registry

TRČKOVÁ, Alžběta, Lenka ŠPINAROVÁ, Jindřich ŠPINAR, Jiří PAŘENICA, Filip MÁLEK et. al.

Basic information

Original name

Comparison of Patients with Reduced and Mildly Reduced Left Ventricular Ejection Fraction: Intermediate Data from the FAR NHL Registry

Authors

TRČKOVÁ, Alžběta (203 Czech Republic, belonging to the institution), Lenka ŠPINAROVÁ (203 Czech Republic, belonging to the institution), Jindřich ŠPINAR (203 Czech Republic, belonging to the institution), Jiří PAŘENICA (203 Czech Republic, belonging to the institution), Filip MÁLEK (203 Czech Republic), Monika ŠPINAROVÁ (203 Czech Republic, belonging to the institution), Ondřej LUDKA (203 Czech Republic, belonging to the institution), Jan KREJČÍ (203 Czech Republic, belonging to the institution), Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution), Klára BENEŠOVÁ (203 Czech Republic, belonging to the institution) and Karel LÁBR (203 Czech Republic, guarantor, belonging to the institution)

Edition

Applied Sciences, BASEL, MDPI, 2022, 2076-3417

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.700

RIV identification code

RIV/00216224:14110/22:00127067

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3390/app122110827

UT WoS

000881040000001

Keywords in English

chronic heart failure; HFrEF; HFmrEF; registry; pharmacotherapy; comorbidities

Abstract

V originále

Introduction: We present the results of a study by the Pharmacology and NeuroHumoral Activation Registry (FAR NHL), which collects data on patients with chronic heart failure. The register contains 1088 patients from three workplaces in the Czech Republic which specialize in the care of patients with heart failure. Objectives: The aim was to obtain a comparison of pharmacotherapy and the incidence of comorbidities in patients with reduced ejection fraction (HFrEF) versus patients with mid-range (or newly mildly reduced) ejection fraction (HFmrEF). Methods: Patients with a baseline left ventricular ejection fraction below 50% were included and divided into HFrEF with EF below 40% and HFmrEF with EF 40–49%, according to the 2016 ESC Guidelines. In addition to the clinical condition, we also monitored laboratory parameters, comorbidities and pharmacotherapy in the patients. Results: Patients with HFrEF versus HFmrEF are more likely to be male (p < 0.008), younger (p < 0.001), have lower systolic blood pressure and are less likely to have ischemic etiology of heart failure (p < 0.001). There were no differences between the groups in the proportion of comorbidities: hypertension, diabetes mellitus, dyslipidemia, ischemic lower limb disease or chronic obstructive pulmonary disease. There were no differences in the proportion of smokers and non-smokers between the groups. Patients with HFrEF have a higher class of New York Heart Association (NYHA), a level of N-terminal fraction of natriuretic peptide B (NT-proBNP), and a higher level of urea and uric acid. They are more often treated with loop diuretics or mineral corticosteroid receptor (MRA) blockers and less often with thiazides (p < 0.001), and also have a worse two-year prognosis. Conclusion: Compared to patients with HFmrEF, patients with HFrEF have more severe heart failure, more pronounced neurohumoral activation and a worse prognosis. They do not differ in the presence of comorbidities.

Links

MUNI/A/1685/2020, interní kód MU

Name: Nové trendy v diagnostice a terapii kardiomyopatií

Investor: Masaryk University

Citovat

TRČKOVÁ, Alžběta, Lenka ŠPINAROVÁ, Jindřich ŠPINAR, Jiří PAŘENICA, Filip MÁLEK, Monika ŠPINAROVÁ, Ondřej LUDKA, Jan KREJČÍ, Jiří JARKOVSKÝ, Klára BENEŠOVÁ and Karel LÁBR. Comparison of Patients with Reduced and Mildly Reduced Left Ventricular Ejection Fraction: Intermediate Data from the FAR NHL Registry. Applied Sciences. BASEL: MDPI, 2022, vol. 12, No 21, p. 1-11. ISSN 2076-3417. Available from: https://dx.doi.org/10.3390/app122110827.

@article{2228646,
   author = {Trčková, Alžběta and Špinarová, Lenka and Špinar, Jindřich and Pařenica, Jiří and Málek, Filip and Špinarová, Monika and Ludka, Ondřej and Krejčí, Jan and Jarkovský, Jiří and Benešová, Klára and Lábr, Karel},
   article_location = {BASEL},
   article_number = {21},
   doi = {http://dx.doi.org/10.3390/app122110827},
   keywords = {chronic heart failure; HFrEF; HFmrEF; registry; pharmacotherapy; comorbidities},
   language = {eng},
   issn = {2076-3417},
   journal = {Applied Sciences},
   title = {Comparison of Patients with Reduced and Mildly Reduced Left Ventricular Ejection Fraction: Intermediate Data from the FAR NHL Registry},
   url = {https://www.mdpi.com/2076-3417/12/21/10827},
   volume = {12},
   year = {2022}
}

TY  - JOUR
ID  - 2228646
AU  - Trčková, Alžběta - Špinarová, Lenka - Špinar, Jindřich - Pařenica, Jiří - Málek, Filip - Špinarová, Monika - Ludka, Ondřej - Krejčí, Jan - Jarkovský, Jiří - Benešová, Klára - Lábr, Karel
PY  - 2022
TI  - Comparison of Patients with Reduced and Mildly Reduced Left Ventricular Ejection Fraction: Intermediate Data from the FAR NHL Registry
JF  - Applied Sciences
VL  - 12
IS  - 21
SP  - 1-11
EP  - 1-11
PB  - MDPI
SN  - 20763417
KW  - chronic heart failure
KW  - HFrEF
KW  - HFmrEF
KW  - registry
KW  - pharmacotherapy
KW  - comorbidities
UR  - https://www.mdpi.com/2076-3417/12/21/10827
N2  - Introduction: We present the results of a study by the Pharmacology and NeuroHumoral Activation Registry (FAR NHL), which collects data on patients with chronic heart failure. The register contains 1088 patients from three workplaces in the Czech Republic which specialize in the care of patients with heart failure. Objectives: The aim was to obtain a comparison of pharmacotherapy and the incidence of comorbidities in patients with reduced ejection fraction (HFrEF) versus patients with mid-range (or newly mildly reduced) ejection fraction (HFmrEF). Methods: Patients with a baseline left ventricular ejection fraction below 50% were included and divided into HFrEF with EF below 40% and HFmrEF with EF 40–49%, according to the 2016 ESC Guidelines. In addition to the clinical condition, we also monitored laboratory parameters, comorbidities and pharmacotherapy in the patients. Results: Patients with HFrEF versus HFmrEF are more likely to be male (p < 0.008), younger (p < 0.001), have lower systolic blood pressure and are less likely to have ischemic etiology of heart failure (p < 0.001). There were no differences between the groups in the proportion of comorbidities: hypertension, diabetes mellitus, dyslipidemia, ischemic lower limb disease or chronic obstructive pulmonary disease. There were no differences in the proportion of smokers and non-smokers between the groups. Patients with HFrEF have a higher class of New York Heart Association (NYHA), a level of N-terminal fraction of natriuretic peptide B (NT-proBNP), and a higher level of urea and uric acid. They are more often treated with loop diuretics or mineral corticosteroid receptor (MRA) blockers and less often with thiazides (p < 0.001), and also have a worse two-year prognosis. Conclusion: Compared to patients with HFmrEF, patients with HFrEF have more severe heart failure, more pronounced neurohumoral activation and a worse prognosis. They do not differ in the presence of comorbidities.
ER  -

TRČKOVÁ, Alžběta, Lenka ŠPINAROVÁ, Jindřich ŠPINAR, Jiří PAŘENICA, Filip MÁLEK, Monika ŠPINAROVÁ, Ondřej LUDKA, Jan KREJČÍ, Jiří JARKOVSKÝ, Klára BENEŠOVÁ and Karel LÁBR. Comparison of Patients with Reduced and Mildly Reduced Left Ventricular Ejection Fraction: Intermediate Data from the FAR NHL Registry. \textit{Applied Sciences}. BASEL: MDPI, 2022, vol.~12, No~21, p.~1-11. ISSN~2076-3417. Available from: https://dx.doi.org/10.3390/app122110827.

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