MICHÁLEK, Jaroslav and Jan ŠMARDA. The advantage of PCR method in monitoring of specific chromosomal aberration in children with acute myeloid leukaemia. In Cells. Praha: Czechoslovak Biological Society, 1999, p. 96. ISBN 80-7232-069-6.
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Basic information
Original name The advantage of PCR method in monitoring of specific chromosomal aberration in children with acute myeloid leukaemia
Authors MICHÁLEK, Jaroslav (203 Czech Republic) and Jan ŠMARDA (203 Czech Republic, guarantor).
Edition Praha, Cells, p. 96-96, 1999.
Publisher Czechoslovak Biological Society
Other information
Original language English
Type of outcome Proceedings paper
Field of Study Genetics and molecular biology
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14310/99:00001441
Organization unit Faculty of Science
ISBN 80-7232-069-6
Keywords in English acute myeloid leukemia
Tags acute myeloid leukemia
Changed by Changed by: prof. RNDr. Jan Šmarda, CSc., učo 1223. Changed: 17/2/2009 05:57.
Abstract
Eighty percent of children with AML show clonal chromosomal aberrations on cytogenetic examination. The most frequent aberrations rexognised in AML are t(8;21), t(15;17), inv(16) and 11q23. These aberrations comprise 10-45% of all AML cases in choldren. Recently, the molecular genetic examination of these specific changes is available with the sensitivity of finding one leukemic cell bearing the translocation in between 1 million of normal cells.
Links
NC4547, research and development projectName: Detekce a sledování vybraných chromozomálních abnormalit na molekulární úrovni u dětí s akutní myeloidní leukemií
Investor: Ministry of Health of the CR, Detection and monitoring of certain chromosomal abnormalities in children suffering from acuta myeloid leukemia
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