Proton pump inhibitors use and risk of preeclampsia: A
meta-analysis of pharmacoepidemiological studies

a 2022

Proton pump inhibitors use and risk of preeclampsia: A meta-analysis of pharmacoepidemiological studies

HUSSAIN, Mohammad Salman, Ambrish SINGH, Benny ANTONY, Jitka KLUGAROVÁ, M. Hassan MURAD et. al.

Basic information

Original name

Proton pump inhibitors use and risk of preeclampsia: A meta-analysis of pharmacoepidemiological studies

Authors

HUSSAIN, Mohammad Salman, Ambrish SINGH, Benny ANTONY, Jitka KLUGAROVÁ, M. Hassan MURAD, Aarthi S. JAYRAJ, Alena LANGAUFOVÁ and Miloslav KLUGAR

Edition

38th International Conference on Pharmacoepidemiology: Advancing Pharmacoepidemiology and Real-World Evidence for the Global Community, August 26–28, 2022, Copenhagen, Denmark, 2022

Other information

Language

English

Type of outcome

Konferenční abstrakt

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.600

Organization unit

Faculty of Medicine

ISSN

UT WoS

000859084401116

Abstract

V originále

Background: Evidence from preclinical studies suggests a preventive effect of proton pump inhibitors (PPIs) in preeclampsia. Recently, several epidemiological studies described conflicting associations between the use of PPIs during pregnancy and preeclampsia risk. Objectives: To evaluate the association between PPIs use and risk of preeclampsia. Methods: Studies reporting the preeclampsia risk with the use of PPIs were eligible for inclusion. Literature screening, data extraction, and risk of bias assessment were performed independently by two investigators. Risk of preeclampsia and preterm preeclampsia among women receiving PPIs during pregnancy. Random-effect meta-analysis was performed to generate relative risks (RR) and 95% confidence intervals (CI). The certainty of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology. Results: This meta-analysis comprised of three studies involving 4 877 565 pregnant women, of whom 119 017 were PPIs users. The included studies were judged to have a low risk of bias. The risk of preeclampsia among pregnant women who received PPIs anytime during pregnancy was statistically significantly increased [ RR 1.27 (95% CI: 1.23 to 1.31)] although the increase was trivial in absolute terms (2 per 1000). Subgroup analysis revealed that the risk was increased in each of the three trimesters. The risk of preterm preeclampsia among pregnant women receiving PPIs anytime during pregnancy was not statistically significantly increased [RR 1.04 (95% CI: 0.70–1.55)]. The certainty evaluated by GRADE in these estimates was low. Conclusions: PPIs use may be associated with a trivial increase in the risk of preeclampsia in pregnant women. There is no evidence supporting that PPI use decreases the risk of preeclampsia or preterm preeclampsia.

Citovat

HUSSAIN, Mohammad Salman, Ambrish SINGH, Benny ANTONY, Jitka KLUGAROVÁ, M. Hassan MURAD, Aarthi S. JAYRAJ, Alena LANGAUFOVÁ and Miloslav KLUGAR. Proton pump inhibitors use and risk of preeclampsia: A meta-analysis of pharmacoepidemiological studies. In 38th International Conference on Pharmacoepidemiology: Advancing Pharmacoepidemiology and Real-World Evidence for the Global Community, August 26–28, 2022, Copenhagen, Denmark. 2022. ISSN 1053-8569.

@proceedings{2231688,
   author = {Hussain, Mohammad Salman and Singh, Ambrish and Antony, Benny and Klugarová, Jitka and Murad, M. Hassan and Jayraj, Aarthi S. and Langaufová, Alena and Klugar, Miloslav},
   booktitle = {38th International Conference on Pharmacoepidemiology: Advancing Pharmacoepidemiology and Real-World Evidence for the Global Community, August 26–28, 2022, Copenhagen, Denmark},
   language = {eng},
   title = {Proton pump inhibitors use and risk of preeclampsia: A meta-analysis of pharmacoepidemiological studies},
   url = {https://onlinelibrary.wiley.com/doi/full/10.1002/pds.5518},
   year = {2022}
}

TY  - CONF
ID  - 2231688
AU  - Hussain, Mohammad Salman - Singh, Ambrish - Antony, Benny - Klugarová, Jitka - Murad, M. Hassan - Jayraj, Aarthi S. - Langaufová, Alena - Klugar, Miloslav
PY  - 2022
TI  - Proton pump inhibitors use and risk of preeclampsia: A meta-analysis of pharmacoepidemiological studies
UR  - https://onlinelibrary.wiley.com/doi/full/10.1002/pds.5518
N2  - Background: Evidence from preclinical studies suggests a preventive effect of proton pump inhibitors (PPIs) in preeclampsia. Recently, several epidemiological studies described conflicting associations between the use of PPIs during pregnancy and preeclampsia risk. Objectives: To evaluate the association between PPIs use and risk of preeclampsia. Methods: Studies reporting the preeclampsia risk with the use of PPIs were eligible for inclusion. Literature screening, data extraction, and risk of bias assessment were performed independently by two investigators. Risk of preeclampsia and preterm preeclampsia among women receiving PPIs during pregnancy. Random-effect meta-analysis was performed to generate relative risks (RR) and 95% confidence intervals (CI). The certainty of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology. Results: This meta-analysis comprised of three studies involving 4 877 565 pregnant women, of whom 119 017 were PPIs users. The included studies were judged to have a low risk of bias. The risk of preeclampsia among pregnant women who received PPIs anytime during pregnancy was statistically significantly increased [ RR 1.27 (95% CI: 1.23 to 1.31)] although the increase was trivial in absolute terms (2 per 1000). Subgroup analysis revealed that the risk was increased in each of the three trimesters. The risk of preterm preeclampsia among pregnant women receiving PPIs anytime during pregnancy was not statistically significantly increased [RR 1.04 (95% CI: 0.70–1.55)]. The certainty evaluated by GRADE in these estimates was low. Conclusions: PPIs use may be associated with a trivial increase in the risk of preeclampsia in pregnant women. There is no evidence supporting that PPI use decreases the risk of preeclampsia or preterm preeclampsia.
ER  -

HUSSAIN, Mohammad Salman, Ambrish SINGH, Benny ANTONY, Jitka KLUGAROVÁ, M. Hassan MURAD, Aarthi S. JAYRAJ, Alena LANGAUFOVÁ and Miloslav KLUGAR. Proton pump inhibitors use and risk of preeclampsia: A meta-analysis of pharmacoepidemiological studies. In \textit{38th International Conference on Pharmacoepidemiology: Advancing Pharmacoepidemiology and Real-World Evidence for the Global Community, August 26–28, 2022, Copenhagen, Denmark}. 2022. ISSN~1053-8569.

Detailed Information on Publication Record