Inflammation and fibrosis characterize different stages of
myocardial remodeling in patients after stereotactic body
radiotherapy of ventricular myocardium for recurrent
ventricular tachycardia

J 2023

Inflammation and fibrosis characterize different stages of myocardial remodeling in patients after stereotactic body radiotherapy of ventricular myocardium for recurrent ventricular tachycardia

KUČERA, Tomáš, Kristína JEDLIČKOVÁ, Marek ŠRAMKO, Petr PEICHL, Jakub CVEK et. al.

Basic information

Original name

Inflammation and fibrosis characterize different stages of myocardial remodeling in patients after stereotactic body radiotherapy of ventricular myocardium for recurrent ventricular tachycardia

Authors

KUČERA, Tomáš (203 Czech Republic, guarantor), Kristína JEDLIČKOVÁ (203 Czech Republic), Marek ŠRAMKO (203 Czech Republic), Petr PEICHL (203 Czech Republic), Jakub CVEK (203 Czech Republic), Lukáš KNYBEL (203 Czech Republic), Pavel HURNÍK (203 Czech Republic), Radek NEUWIRTH (203 Czech Republic, belonging to the institution), Otakar JIRAVSKÝ (203 Czech Republic, belonging to the institution), Luděk VOSKA (203 Czech Republic) and Josef KAUTZNER (203 Czech Republic)

Edition

CARDIOVASCULAR PATHOLOGY, NEW YORK, ELSEVIER SCIENCE INC, 2023, 1054-8807

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.700 in 2022

RIV identification code

RIV/00216224:14110/23:00130065

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.carpath.2022.107488

UT WoS

000892258800002

Keywords in English

radioablation; arrhythmia; apoptosis; inflammation; macrophage; immunohistochemistry

Abstract

V originále

We performed a histological and immunohistochemical analysis of myocardia from 3 patients who un-derwent radiosurgery and died for various reasons 3 months to 9 months after radiotherapy. In Case 1 (death 3 months after radiotherapy) we observed a sharp transition between relatively intact and irradiated regions. In the myolytic foci, only scattered cardiomyocytes were left and the area was in-filtrated by immune cells. Using immunohistochemistry we detected numerous inflammatory cells in-cluding CD68 + /CD11c + macrophages, CD4 + and CD8 + T-lymphocytes and some scattered CD20 + B-lymphocytes. Mast cells were diminished in contrast to viable myocardium. In Case 2 and Case 3 (death 6 and 9 months after radiotherapy, respectively) we found mostly fibrosis, infiltration by adipose tissue and foci of calcification. Inflammatory infiltrates were less pronounced. Our observations are in accor-dance with animal experimental studies and confirm a progress from myolysis to fibrosis. In addition, we demonstrate a role of pro-inflammatory macrophages in the earlier stages of myocardial remodeling after stereotactic radioablation for ventricular tachycardia.

Citovat

KUČERA, Tomáš, Kristína JEDLIČKOVÁ, Marek ŠRAMKO, Petr PEICHL, Jakub CVEK, Lukáš KNYBEL, Pavel HURNÍK, Radek NEUWIRTH, Otakar JIRAVSKÝ, Luděk VOSKA and Josef KAUTZNER. Inflammation and fibrosis characterize different stages of myocardial remodeling in patients after stereotactic body radiotherapy of ventricular myocardium for recurrent ventricular tachycardia. CARDIOVASCULAR PATHOLOGY. NEW YORK: ELSEVIER SCIENCE INC, 2023, vol. 62, January-February 2023, p. 1-8. ISSN 1054-8807. Available from: https://dx.doi.org/10.1016/j.carpath.2022.107488.

@article{2231817,
   author = {Kučera, Tomáš and Jedličková, Kristína and Šramko, Marek and Peichl, Petr and Cvek, Jakub and Knybel, Lukáš and Hurník, Pavel and Neuwirth, Radek and Jiravský, Otakar and Voska, Luděk and Kautzner, Josef},
   article_location = {NEW YORK},
   article_number = {January-February 2023},
   doi = {http://dx.doi.org/10.1016/j.carpath.2022.107488},
   keywords = {radioablation; arrhythmia; apoptosis; inflammation; macrophage; immunohistochemistry},
   language = {eng},
   issn = {1054-8807},
   journal = {CARDIOVASCULAR PATHOLOGY},
   title = {Inflammation and fibrosis characterize different stages of myocardial remodeling in patients after stereotactic body radiotherapy of ventricular myocardium for recurrent ventricular tachycardia},
   url = {https://www.sciencedirect.com/science/article/pii/S1054880722000825?via%3Dihub},
   volume = {62},
   year = {2023}
}

TY  - JOUR
ID  - 2231817
AU  - Kučera, Tomáš - Jedličková, Kristína - Šramko, Marek - Peichl, Petr - Cvek, Jakub - Knybel, Lukáš - Hurník, Pavel - Neuwirth, Radek - Jiravský, Otakar - Voska, Luděk - Kautzner, Josef
PY  - 2023
TI  - Inflammation and fibrosis characterize different stages of myocardial remodeling in patients after stereotactic body radiotherapy of ventricular myocardium for recurrent ventricular tachycardia
JF  - CARDIOVASCULAR PATHOLOGY
VL  - 62
IS  - January-February 2023
SP  - 1-8
EP  - 1-8
PB  - ELSEVIER SCIENCE INC
SN  - 10548807
KW  - radioablation
KW  - arrhythmia
KW  - apoptosis
KW  - inflammation
KW  - macrophage
KW  - immunohistochemistry
UR  - https://www.sciencedirect.com/science/article/pii/S1054880722000825?via%3Dihub
N2  - We performed a histological and immunohistochemical analysis of myocardia from 3 patients who un-derwent radiosurgery and died for various reasons 3 months to 9 months after radiotherapy. In Case 1 (death 3 months after radiotherapy) we observed a sharp transition between relatively intact and irradiated regions. In the myolytic foci, only scattered cardiomyocytes were left and the area was in-filtrated by immune cells. Using immunohistochemistry we detected numerous inflammatory cells in-cluding CD68 + /CD11c + macrophages, CD4 + and CD8 + T-lymphocytes and some scattered CD20 + B-lymphocytes. Mast cells were diminished in contrast to viable myocardium. In Case 2 and Case 3 (death 6 and 9 months after radiotherapy, respectively) we found mostly fibrosis, infiltration by adipose tissue and foci of calcification. Inflammatory infiltrates were less pronounced. Our observations are in accor-dance with animal experimental studies and confirm a progress from myolysis to fibrosis. In addition, we demonstrate a role of pro-inflammatory macrophages in the earlier stages of myocardial remodeling after stereotactic radioablation for ventricular tachycardia.
ER  -

KUČERA, Tomáš, Kristína JEDLIČKOVÁ, Marek ŠRAMKO, Petr PEICHL, Jakub CVEK, Lukáš KNYBEL, Pavel HURNÍK, Radek NEUWIRTH, Otakar JIRAVSKÝ, Luděk VOSKA and Josef KAUTZNER. Inflammation and fibrosis characterize different stages of myocardial remodeling in patients after stereotactic body radiotherapy of ventricular myocardium for recurrent ventricular tachycardia. \textit{CARDIOVASCULAR PATHOLOGY}. NEW YORK: ELSEVIER SCIENCE INC, 2023, vol.~62, January-February 2023, p.~1-8. ISSN~1054-8807. Available from: https://dx.doi.org/10.1016/j.carpath.2022.107488.

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