| KUČERA, Tomáš, Kristína JEDLIČKOVÁ, Marek ŠRAMKO, Petr PEICHL, Jakub CVEK, Lukáš KNYBEL, Pavel HURNÍK, Radek NEUWIRTH, Otakar JIRAVSKÝ, Luděk VOSKA and Josef KAUTZNER. Inflammation and fibrosis characterize different stages of myocardial remodeling in patients after stereotactic body radiotherapy of ventricular myocardium for recurrent ventricular tachycardia. CARDIOVASCULAR PATHOLOGY. NEW YORK: ELSEVIER SCIENCE INC, 2023, vol. 62, January-February 2023, p. 1-8. ISSN 1054-8807. Available from: https://dx.doi.org/10.1016/j.carpath.2022.107488. |
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@article{2231817,
author = {Kučera, Tomáš and Jedličková, Kristína and Šramko, Marek and Peichl, Petr and Cvek, Jakub and Knybel, Lukáš and Hurník, Pavel and Neuwirth, Radek and Jiravský, Otakar and Voska, Luděk and Kautzner, Josef},
article_location = {NEW YORK},
article_number = {January-February 2023},
doi = {http://dx.doi.org/10.1016/j.carpath.2022.107488},
keywords = {radioablation; arrhythmia; apoptosis; inflammation; macrophage; immunohistochemistry},
language = {eng},
issn = {1054-8807},
journal = {CARDIOVASCULAR PATHOLOGY},
title = {Inflammation and fibrosis characterize different stages of myocardial remodeling in patients after stereotactic body radiotherapy of ventricular myocardium for recurrent ventricular tachycardia},
url = {https://www.sciencedirect.com/science/article/pii/S1054880722000825?via%3Dihub},
volume = {62},
year = {2023}
}
TY - JOUR
ID - 2231817
AU - Kučera, Tomáš - Jedličková, Kristína - Šramko, Marek - Peichl, Petr - Cvek, Jakub - Knybel, Lukáš - Hurník, Pavel - Neuwirth, Radek - Jiravský, Otakar - Voska, Luděk - Kautzner, Josef
PY - 2023
TI - Inflammation and fibrosis characterize different stages of myocardial remodeling in patients after stereotactic body radiotherapy of ventricular myocardium for recurrent ventricular tachycardia
JF - CARDIOVASCULAR PATHOLOGY
VL - 62
IS - January-February 2023
SP - 1-8
EP - 1-8
PB - ELSEVIER SCIENCE INC
SN - 10548807
KW - radioablation
KW - arrhythmia
KW - apoptosis
KW - inflammation
KW - macrophage
KW - immunohistochemistry
UR - https://www.sciencedirect.com/science/article/pii/S1054880722000825?via%3Dihub
N2 - We performed a histological and immunohistochemical analysis of myocardia from 3 patients who un-derwent radiosurgery and died for various reasons 3 months to 9 months after radiotherapy. In Case 1 (death 3 months after radiotherapy) we observed a sharp transition between relatively intact and irradiated regions. In the myolytic foci, only scattered cardiomyocytes were left and the area was in-filtrated by immune cells. Using immunohistochemistry we detected numerous inflammatory cells in-cluding CD68 + /CD11c + macrophages, CD4 + and CD8 + T-lymphocytes and some scattered CD20 + B-lymphocytes. Mast cells were diminished in contrast to viable myocardium. In Case 2 and Case 3 (death 6 and 9 months after radiotherapy, respectively) we found mostly fibrosis, infiltration by adipose tissue and foci of calcification. Inflammatory infiltrates were less pronounced. Our observations are in accor-dance with animal experimental studies and confirm a progress from myolysis to fibrosis. In addition, we demonstrate a role of pro-inflammatory macrophages in the earlier stages of myocardial remodeling after stereotactic radioablation for ventricular tachycardia.
ER -
KUČERA, Tomáš, Kristína JEDLIČKOVÁ, Marek ŠRAMKO, Petr PEICHL, Jakub CVEK, Lukáš KNYBEL, Pavel HURNÍK, Radek NEUWIRTH, Otakar JIRAVSKÝ, Luděk VOSKA and Josef KAUTZNER. Inflammation and fibrosis characterize different stages of myocardial remodeling in patients after stereotactic body radiotherapy of ventricular myocardium for recurrent ventricular tachycardia. \textit{CARDIOVASCULAR PATHOLOGY}. NEW YORK: ELSEVIER SCIENCE INC, 2023, vol.~62, January-February 2023, p.~1-8. ISSN~1054-8807. Available from: https://dx.doi.org/10.1016/j.carpath.2022.107488.
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