J 2022

Epigenetic Regulations of Perineural Invasion in Head and Neck Squamous Cell Carcinoma

HURNÍK, Pavel, Zuzana CHYRA, Tereza ŠEVČÍKOVÁ, Jan ŠTEMBÍREK, Kateřina SMEŠNÝ TRTKOVÁ et. al.

Basic information

Original name

Epigenetic Regulations of Perineural Invasion in Head and Neck Squamous Cell Carcinoma

Authors

HURNÍK, Pavel (203 Czech Republic, belonging to the institution), Zuzana CHYRA (203 Czech Republic), Tereza ŠEVČÍKOVÁ, Jan ŠTEMBÍREK, Kateřina SMEŠNÝ TRTKOVÁ, Daria A GAYKALOVA, Marcela BUCHTOVÁ (203 Czech Republic, belonging to the institution) and Eva HRUBÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Frontiers in Genetics, Lausanne, Frontiers Media S.A. 2022, 1664-8021

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 3.700

RIV identification code

RIV/00216224:14310/22:00127163

Organization unit

Faculty of Science

UT WoS

000875197900001

Keywords in English

HNSCC; perineural invasion; epigenetics; oral cancer; miRNAs

Tags

International impact, Reviewed
Změněno: 13/3/2023 08:00, Mgr. Marie Šípková, DiS.

Abstract

V originále

Carcinomas of the oral cavity and oropharynx belong among the ten most common malignancies in the human population. The prognosis of head and neck squamous cell carcinoma (HNSCC) is determined by the degree of invasiveness of the primary tumor and by the extent of metastatic spread into regional and distant lymph nodes. Moreover, the level of the perineural invasion itself associates with tumor localization, invasion’s extent, and the presence of nodal metastases. Here, we summarize the current knowledge about different aspects of epigenetic changes, which can be associated with HNSCC while focusing on perineural invasion (PNI). We review epigenetic modifications of the genes involved in the PNI process in HNSCC from the omics perspective and specific epigenetic modifications in OSCC or other neurotropic cancers associated with perineural invasion. Moreover, we summarize DNA methylation status of tumor-suppressor genes, methylation and demethylation enzymes and histone post-translational modifications associated with PNI. The influence of other epigenetic factors on the HNSCC incidence and perineural invasion such as tobacco, alcohol and oral microbiome is overviewed and HPV infection is discussed as an epigenetic factor associated with OSCC and related perineural invasion. Understanding epigenetic regulations of axon growth that lead to tumorous spread or uncovering the molecular control of axon interaction with cancer tissue can help to discover new therapeutic targets for these tumors.