Detailed Information on Publication Record
2022
Olanzapine concentrations in dried blood spot vs. plasma
PELCOVÁ, Marta, Jan JUŘICA, Radka VAŇUŠANÍKOVÁ, Ondřej PEŠ, Zdeněk GLATZ et. al.Basic information
Original name
Olanzapine concentrations in dried blood spot vs. plasma
Name in Czech
Koncenrace olanzapinu v suché kapce krve vs. plasmě
Name (in English)
Olanzapine concentrations in dried blood spot vs. plasma
Authors
Edition
2022
Other information
Type of outcome
Konferenční abstrakt
Confidentiality degree
není předmětem státního či obchodního tajemství
Keywords (in Czech)
olanzapin, plasma, suchá kapce krve, korelace
Keywords in English
olanzapine, plasma, dried blood spot, correlation
Změněno: 29/11/2022 12:46, Mgr. Marta Pelcová, Ph.D.
V originále
Olanzapine (OLA) is an atypical antipsychotic approved for the treatment of schizophrenia and bipolar disorder nearly 20 years ago. Therapeutic drug monitoring is strongly recommended according to the Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology, and the therapeutic range of 20 to 80 ng/mL in plasma has been proposed. Dried blood spot (DBS) represents mini-invasive microsampling method, but no reference range has been established yet. The developed LC-MS method offers short analysis cycle time (12 min) with satisfactory sensitivity covering recommended OLA therapeutic concentration range in both types of samples (plasma and DBS). Primary patient plasma and DBS samples were acquired, quantified and preliminary comparison results were derived.
In Czech
Olanzapine je atypické antipsychotikum schválené k léčbě schizofrenie a bipolární porucha již před 20 roky. Bylo vydáno doporučení pro terapeutické monitorování léčby s doporučeným rozmezím 20-80 ng/ml. Chuchá krevní skvrny představuje velmi málo invazivní odběrovou metodu. Refenční pro tento typ vzorku ještě nebylo stanoveno. Vyvinutá LC-MS metoda nabízí krátký čas analýzy dobrou citlivostí pokrývající terapeutické koncentrační rozmezí OLA ve dvou typech vzorků (plasmě a DBS). Vzorky pacientů byly po doručení do laboratoře zpracovány, kvantifikovány a bylo provedeno porovnání získaných hodnot.
In English
Olanzapine (OLA) is an atypical antipsychotic approved for the treatment of schizophrenia and bipolar disorder nearly 20 years ago. Therapeutic drug monitoring is strongly recommended according to the Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology, and the therapeutic range of 20 to 80 ng/mL in plasma has been proposed. Dried blood spot (DBS) represents mini-invasive microsampling method, but no reference range has been established yet. The developed LC-MS method offers short analysis cycle time (12 min) with satisfactory sensitivity covering recommended OLA therapeutic concentration range in both types of samples (plasma and DBS). Primary patient plasma and DBS samples were acquired, quantified and preliminary comparison results were derived.
Links
| MUNI/G/1464/2018, interní kód MU |
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