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HÖNIG, Václav, Jan KAMIŠ, Aneta MARŠÍKOVÁ, Tereza MATĚJKOVÁ, Pavel STOPKA, Anna MÁCOVÁ, Daniel RŮŽEK a Jana KVIČEROVÁ. Orthohantaviruses in Reservoir and Atypical Hosts in the Czech Republic: Spillover Infection and Indication of Virus-Specific Tissue Tropism. Microbiology Spectrum. American Society for Microbiology, 2022, roč. 10, č. 5, s. 1-15. ISSN 2165-0497. Dostupné z: https://dx.doi.org/10.1128/spectrum.01306-22.

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Základní údaje
Originální název	Orthohantaviruses in Reservoir and Atypical Hosts in the Czech Republic: Spillover Infection and Indication of Virus-Specific Tissue Tropism
Autoři	HÖNIG, Václav, Jan KAMIŠ, Aneta MARŠÍKOVÁ, Tereza MATĚJKOVÁ, Pavel STOPKA, Anna MÁCOVÁ, Daniel RŮŽEK (203 Česká republika, domácí) a Jana KVIČEROVÁ.
Vydání	Microbiology Spectrum, American Society for Microbiology, 2022, 2165-0497.

Další údaje
Originální jazyk	angličtina
Typ výsledku	Článek v odborném periodiku
Obor	10607 Virology
Stát vydavatele	Spojené státy
Utajení	není předmětem státního či obchodního tajemství
WWW	URL
Impakt faktor	Impact factor: 3.700
Kód RIV	RIV/00216224:14310/22:00127194
Organizační jednotka	Přírodovědecká fakulta
Doi	http://dx.doi.org/10.1128/spectrum.01306-22
UT WoS	000861828500001
Klíčová slova anglicky	Kurkino virus; Tula virus; Seewis virus; Asikkala virus; rodents; Eulipotyphla; phylogeny; host specificity; tissue specificity; zoonoses; zoonosis
Štítky	rivok
Příznaky	Mezinárodní význam, Recenzováno
Změnil	Změnila: Mgr. Marie Šípková, DiS., učo 437722. Změněno: 21. 11. 2022 10:29.

Anotace
Orthohantaviruses (genus Orthohantavirus) are a diverse group of viruses that are closely associated with their natural hosts (rodents, shrews, and moles). Several orthohantaviruses cause severe disease in humans. Central and western Europe are areas with emerging orthohantavirus occurrences. In our study, several orthohantaviruses, including the pathogenic Kurkino virus (KURV), were detected in their natural hosts trapped at several study sites in the Czech Republic. KURV was detected mainly in its typical host, the striped field mouse (Apodemus agrarius). Nevertheless, spillover infections were also detected in wood mice (Apodemus sylvaticus) and common voles (Microtus arvalis). Similarly, Tula virus (TULV) was found primarily in common voles, and events of spillover to rodents of other host species, including Apodemus spp., were recorded. In addition, unlike most previous studies, different tissues were sampled and compared to assess their suitability for orthohantavirus screening and possible tissue tropism. Our data suggest possible virus-specific tissue tropism in rodent hosts. TULV was most commonly detected in the lung tissue, whereas KURV was more common in the liver, spleen, and brain. Moreover, Seewis and Asikkala viruses were detected in randomly found common shrews (Sorex araneus). In conclusion, we have demonstrated the presence of human-pathogenic KURV and the potentially pathogenic TULV in their typical hosts as well as their spillover to atypical host species belonging to another family. Furthermore, we suggest the possibility of virus-specific tissue tropism of orthohantaviruses in their natural hosts.

Anotace

Orthohantaviruses (genus Orthohantavirus) are a diverse group of viruses that are closely associated with their natural hosts (rodents, shrews, and moles). Several orthohantaviruses cause severe disease in humans. Central and western Europe are areas with emerging orthohantavirus occurrences. In our study, several orthohantaviruses, including the pathogenic Kurkino virus (KURV), were detected in their natural hosts trapped at several study sites in the Czech Republic. KURV was detected mainly in its typical host, the striped field mouse (Apodemus agrarius). Nevertheless, spillover infections were also detected in wood mice (Apodemus sylvaticus) and common voles (Microtus arvalis). Similarly, Tula virus (TULV) was found primarily in common voles, and events of spillover to rodents of other host species, including Apodemus spp., were recorded. In addition, unlike most previous studies, different tissues were sampled and compared to assess their suitability for orthohantavirus screening and possible tissue tropism. Our data suggest possible virus-specific tissue tropism in rodent hosts. TULV was most commonly detected in the lung tissue, whereas KURV was more common in the liver, spleen, and brain. Moreover, Seewis and Asikkala viruses were detected in randomly found common shrews (Sorex araneus). In conclusion, we have demonstrated the presence of human-pathogenic KURV and the potentially pathogenic TULV in their typical hosts as well as their spillover to atypical host species belonging to another family. Furthermore, we suggest the possibility of virus-specific tissue tropism of orthohantaviruses in their natural hosts.