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@article{2233247,
author = {Hönig, Václav and Kamiš, Jan and Maršíková, Aneta and Matějková, Tereza and Stopka, Pavel and Mácová, Anna and Růžek, Daniel and Kvičerová, Jana},
article_number = {5},
doi = {http://dx.doi.org/10.1128/spectrum.01306-22},
keywords = {Kurkino virus; Tula virus; Seewis virus; Asikkala virus; rodents; Eulipotyphla; phylogeny; host specificity; tissue specificity; zoonoses; zoonosis},
language = {eng},
issn = {2165-0497},
journal = {Microbiology Spectrum},
title = {Orthohantaviruses in Reservoir and Atypical Hosts in the Czech Republic: Spillover Infection and Indication of Virus-Specific Tissue Tropism},
url = {https://journals.asm.org/doi/10.1128/spectrum.01306-22},
volume = {10},
year = {2022}
}
TY - JOUR
ID - 2233247
AU - Hönig, Václav - Kamiš, Jan - Maršíková, Aneta - Matějková, Tereza - Stopka, Pavel - Mácová, Anna - Růžek, Daniel - Kvičerová, Jana
PY - 2022
TI - Orthohantaviruses in Reservoir and Atypical Hosts in the Czech Republic: Spillover Infection and Indication of Virus-Specific Tissue Tropism
JF - Microbiology Spectrum
VL - 10
IS - 5
SP - 1-15
EP - 1-15
PB - American Society for Microbiology
SN - 21650497
KW - Kurkino virus
KW - Tula virus
KW - Seewis virus
KW - Asikkala virus
KW - rodents
KW - Eulipotyphla
KW - phylogeny
KW - host specificity
KW - tissue specificity
KW - zoonoses
KW - zoonosis
UR - https://journals.asm.org/doi/10.1128/spectrum.01306-22
N2 - Orthohantaviruses (genus Orthohantavirus) are a diverse group of viruses that are closely associated with their natural hosts (rodents, shrews, and moles). Several orthohantaviruses cause severe disease in humans. Central and western Europe are areas with emerging orthohantavirus occurrences. In our study, several orthohantaviruses, including the pathogenic Kurkino virus (KURV), were detected in their natural hosts trapped at several study sites in the Czech Republic. KURV was detected mainly in its typical host, the striped field mouse (Apodemus agrarius). Nevertheless, spillover infections were also detected in wood mice (Apodemus sylvaticus) and common voles (Microtus arvalis). Similarly, Tula virus (TULV) was found primarily in common voles, and events of spillover to rodents of other host species, including Apodemus spp., were recorded. In addition, unlike most previous studies, different tissues were sampled and compared to assess their suitability for orthohantavirus screening and possible tissue tropism. Our data suggest possible virus-specific tissue tropism in rodent hosts. TULV was most commonly detected in the lung tissue, whereas KURV was more common in the liver, spleen, and brain. Moreover, Seewis and Asikkala viruses were detected in randomly found common shrews (Sorex araneus). In conclusion, we have demonstrated the presence of human-pathogenic KURV and the potentially pathogenic TULV in their typical hosts as well as their spillover to atypical host species belonging to another family. Furthermore, we suggest the possibility of virus-specific tissue tropism of orthohantaviruses in their natural hosts.
ER -
HÖNIG, Václav, Jan KAMIŠ, Aneta MARŠÍKOVÁ, Tereza MATĚJKOVÁ, Pavel STOPKA, Anna MÁCOVÁ, Daniel RŮŽEK and Jana KVIČEROVÁ. Orthohantaviruses in Reservoir and Atypical Hosts in the Czech Republic: Spillover Infection and Indication of Virus-Specific Tissue Tropism. \textit{Microbiology Spectrum}. American Society for Microbiology, 2022, vol.~10, No~5, p.~1-15. ISSN~2165-0497. Available from: https://dx.doi.org/10.1128/spectrum.01306-22.
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