Self-Propelled Magnetic Dendrite-Shaped Microrobots for
Photodynamic Prostate Cancer Therapy

J 2022

Self-Propelled Magnetic Dendrite-Shaped Microrobots for Photodynamic Prostate Cancer Therapy

PENG, Xia, Mario URSO, Jan BALVAN, Michal MASAŘÍK, Martin PUMERA et. al.

Basic information

Original name

Self-Propelled Magnetic Dendrite-Shaped Microrobots for Photodynamic Prostate Cancer Therapy

Authors

PENG, Xia, Mario URSO, Jan BALVAN (203 Czech Republic, belonging to the institution), Michal MASAŘÍK (203 Czech Republic, belonging to the institution) and Martin PUMERA (203 Czech Republic, guarantor)

Edition

Angewandte Chemie International Edition, WEINHEIM (GERMANY), Verlag Chemie, 2022, 1433-7851

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

20601 Medical engineering

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 16.600

RIV identification code

RIV/00216224:14110/22:00127215

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1002/anie.202213505

UT WoS

000871719800001

Keywords in English

Cargo Transportation; Micromachines; Micromotors; Photocatalysis; Tumor Cells

Abstract

V originále

Photocatalytic micromotors that exhibit wireless and controllable motion by light have been extensively explored for cancer treatment by photodynamic therapy (PDT). However, overexpressed glutathione (GSH) in the tumor microenvironment can down-regulate the reactive oxygen species (ROS) level for cancer therapy. Herein, we present dendrite-shaped light-powered hematite microrobots as an effective GSH depletion agent for PDT of prostate cancer cells. These hematite microrobots can display negative phototactic motion under light irradiation and flexible actuation in a defined path controlled by an external magnetic field. Non-contact transportation of micro-sized cells can be achieved by manipulating the microrobot's motion. In addition, the biocompatible microrobots induce GSH depletion and greatly enhance PDT performance. The proposed dendrite-shaped hematite microrobots contribute to developing dual light/magnetic field-powered micromachines for the biomedical field.

Links

LM2018127, research and development project

Name: Česká infrastruktura pro integrativní strukturní biologii (Acronym: CIISB)

Investor: Ministry of Education, Youth and Sports of the CR

NU21-08-00407, research and development project

Name: Funkční nanoroboti pro navigovanou kombinovanou nádorovou terapii

Investor: Ministry of Health of the CR, Subprogram 1 - standard

90110, large research infrastructures

Name: CzechNanoLab

Citovat

PENG, Xia, Mario URSO, Jan BALVAN, Michal MASAŘÍK and Martin PUMERA. Self-Propelled Magnetic Dendrite-Shaped Microrobots for Photodynamic Prostate Cancer Therapy. Angewandte Chemie International Edition. WEINHEIM (GERMANY): Verlag Chemie, 2022, vol. 61, No 48, p. 1-8. ISSN 1433-7851. Available from: https://dx.doi.org/10.1002/anie.202213505.

@article{2233422,
   author = {Peng, Xia and Urso, Mario and Balvan, Jan and Masařík, Michal and Pumera, Martin},
   article_location = {WEINHEIM (GERMANY)},
   article_number = {48},
   doi = {http://dx.doi.org/10.1002/anie.202213505},
   keywords = {Cargo Transportation; Micromachines; Micromotors; Photocatalysis; Tumor Cells},
   language = {eng},
   issn = {1433-7851},
   journal = {Angewandte Chemie International Edition},
   title = {Self-Propelled Magnetic Dendrite-Shaped Microrobots for Photodynamic Prostate Cancer Therapy},
   url = {https://onlinelibrary.wiley.com/doi/10.1002/anie.202213505},
   volume = {61},
   year = {2022}
}

TY  - JOUR
ID  - 2233422
AU  - Peng, Xia - Urso, Mario - Balvan, Jan - Masařík, Michal - Pumera, Martin
PY  - 2022
TI  - Self-Propelled Magnetic Dendrite-Shaped Microrobots for Photodynamic Prostate Cancer Therapy
JF  - Angewandte Chemie International Edition
VL  - 61
IS  - 48
SP  - 1-8
EP  - 1-8
PB  - Verlag Chemie
SN  - 14337851
KW  - Cargo Transportation
KW  - Micromachines
KW  - Micromotors
KW  - Photocatalysis
KW  - Tumor Cells
UR  - https://onlinelibrary.wiley.com/doi/10.1002/anie.202213505
N2  - Photocatalytic micromotors that exhibit wireless and controllable motion by light have been extensively explored for cancer treatment by photodynamic therapy (PDT). However, overexpressed glutathione (GSH) in the tumor microenvironment can down-regulate the reactive oxygen species (ROS) level for cancer therapy. Herein, we present dendrite-shaped light-powered hematite microrobots as an effective GSH depletion agent for PDT of prostate cancer cells. These hematite microrobots can display negative phototactic motion under light irradiation and flexible actuation in a defined path controlled by an external magnetic field. Non-contact transportation of micro-sized cells can be achieved by manipulating the microrobot's motion. In addition, the biocompatible microrobots induce GSH depletion and greatly enhance PDT performance. The proposed dendrite-shaped hematite microrobots contribute to developing dual light/magnetic field-powered micromachines for the biomedical field.
ER  -

PENG, Xia, Mario URSO, Jan BALVAN, Michal MASAŘÍK and Martin PUMERA. Self-Propelled Magnetic Dendrite-Shaped Microrobots for Photodynamic Prostate Cancer Therapy. \textit{Angewandte Chemie International Edition}. WEINHEIM (GERMANY): Verlag Chemie, 2022, vol.~61, No~48, p.~1-8. ISSN~1433-7851. Available from: https://dx.doi.org/10.1002/anie.202213505.

Detailed Information on Publication Record