| PENG, Xia, Mario URSO, Jan BALVAN, Michal MASAŘÍK and Martin PUMERA. Self-Propelled Magnetic Dendrite-Shaped Microrobots for Photodynamic Prostate Cancer Therapy. Angewandte Chemie International Edition. WEINHEIM (GERMANY): Verlag Chemie, 2022, vol. 61, No 48, p. 1-8. ISSN 1433-7851. Available from: https://dx.doi.org/10.1002/anie.202213505. |
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@article{2233422,
author = {Peng, Xia and Urso, Mario and Balvan, Jan and Masařík, Michal and Pumera, Martin},
article_location = {WEINHEIM (GERMANY)},
article_number = {48},
doi = {http://dx.doi.org/10.1002/anie.202213505},
keywords = {Cargo Transportation; Micromachines; Micromotors; Photocatalysis; Tumor Cells},
language = {eng},
issn = {1433-7851},
journal = {Angewandte Chemie International Edition},
title = {Self-Propelled Magnetic Dendrite-Shaped Microrobots for Photodynamic Prostate Cancer Therapy},
url = {https://onlinelibrary.wiley.com/doi/10.1002/anie.202213505},
volume = {61},
year = {2022}
}
TY - JOUR
ID - 2233422
AU - Peng, Xia - Urso, Mario - Balvan, Jan - Masařík, Michal - Pumera, Martin
PY - 2022
TI - Self-Propelled Magnetic Dendrite-Shaped Microrobots for Photodynamic Prostate Cancer Therapy
JF - Angewandte Chemie International Edition
VL - 61
IS - 48
SP - 1-8
EP - 1-8
PB - Verlag Chemie
SN - 14337851
KW - Cargo Transportation
KW - Micromachines
KW - Micromotors
KW - Photocatalysis
KW - Tumor Cells
UR - https://onlinelibrary.wiley.com/doi/10.1002/anie.202213505
N2 - Photocatalytic micromotors that exhibit wireless and controllable motion by light have been extensively explored for cancer treatment by photodynamic therapy (PDT). However, overexpressed glutathione (GSH) in the tumor microenvironment can down-regulate the reactive oxygen species (ROS) level for cancer therapy. Herein, we present dendrite-shaped light-powered hematite microrobots as an effective GSH depletion agent for PDT of prostate cancer cells. These hematite microrobots can display negative phototactic motion under light irradiation and flexible actuation in a defined path controlled by an external magnetic field. Non-contact transportation of micro-sized cells can be achieved by manipulating the microrobot's motion. In addition, the biocompatible microrobots induce GSH depletion and greatly enhance PDT performance. The proposed dendrite-shaped hematite microrobots contribute to developing dual light/magnetic field-powered micromachines for the biomedical field.
ER -
PENG, Xia, Mario URSO, Jan BALVAN, Michal MASAŘÍK and Martin PUMERA. Self-Propelled Magnetic Dendrite-Shaped Microrobots for Photodynamic Prostate Cancer Therapy. \textit{Angewandte Chemie International Edition}. WEINHEIM (GERMANY): Verlag Chemie, 2022, vol.~61, No~48, p.~1-8. ISSN~1433-7851. Available from: https://dx.doi.org/10.1002/anie.202213505.
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