ZAVESKY, Ludek, Eva JANDÁKOVÁ, Vít WEINBERGER, Veronika HANZIKOVA, Ondrej SLANAR and Milada KOHOUTOVA. Ascites in ovarian cancer: MicroRNA deregulations and their potential roles in ovarian carcinogenesis. Cancer Biomarkers. Amsterdam: IOS Press, vol. 33, No 1, p. 1-16. ISSN 1574-0153. doi:10.3233/CBM-210219. 2022.
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Basic information
Original name Ascites in ovarian cancer: MicroRNA deregulations and their potential roles in ovarian carcinogenesis
Authors ZAVESKY, Ludek (203 Czech Republic, guarantor), Eva JANDÁKOVÁ (203 Czech Republic, belonging to the institution), Vít WEINBERGER (203 Czech Republic, belonging to the institution), Veronika HANZIKOVA (203 Czech Republic), Ondrej SLANAR (203 Czech Republic) and Milada KOHOUTOVA (203 Czech Republic).
Edition Cancer Biomarkers, Amsterdam, IOS Press, 2022, 1574-0153.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30204 Oncology
Country of publisher Netherlands
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 3.100
RIV identification code RIV/00216224:14110/22:00127221
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.3233/CBM-210219
UT WoS 000782366700001
Keywords in English Ovarian cancer; ascites; effusion; microRNA; tumor; tumor suppressor; oncogene
Tags 14110230, 14110411, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 22/11/2022 11:05.
Abstract
Ovarian cancer comprises the most lethal gynecologic malignancy and is accompanied by the high potential for the incidence of metastasis, recurrence and chemotherapy resistance, often associated with a formation of ascitic fluid. The differentially expressed ascites-derived microRNAs may be linked to ovarian carcinogenesis. The article focuses on a number of miRNAs that share a common expression pattern as determined by independent studies using ascites samples and with regard to their functions and outcomes in experimental and clinical investigations. Let-7b and miR-143 have featured as tumor suppressors in ovarian cancer, which is in line with data on other types of cancer. Although two miRNAs, i.e. miR-26a-5p and miR-145-5p, act principally as tumor suppressor miRNAs, they occasionally exhibit oncogenic roles. The performance of miR-95-3p, upregulated in ascites, is open to debate given the current lack of supportive data on ovarian cancer; however, data on other cancers indicates its probable oncogenic role. Different findings have been reported for miR-182-5p and miR-200c-3p; in addition to their presumed oncogenic roles, contrasting findings have indicated their ambivalent functions. Further research is required for the identification and evaluation of the potential of specific miRNAs in the diagnosis, prediction, treatment and outcomes of ovarian cancer patients.
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