MAZÚR, Andrej, Kristián BRAT, Pavel HOMOLKA, Zdeněk MERTA, Michal SVOBODA, Monika BRATOVÁ, Vladimír ŠRÁMEK, Lyle OLSON a Ivan ČUNDRLE. Ventilatory efficiency is superior to peak oxygen uptake for prediction of lung resection cardiovascular complications. PLoS ONE. SAN FRANCISCO: PUBLIC LIBRARY SCIENCE, 2022, roč. 17, č. 8, s. 1-12. ISSN 1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0272984. |
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@article{2234122, author = {Mazúr, Andrej and Brat, Kristián and Homolka, Pavel and Merta, Zdeněk and Svoboda, Michal and Bratová, Monika and Šrámek, Vladimír and Olson, Lyle and Čundrle, Ivan}, article_location = {SAN FRANCISCO}, article_number = {8}, doi = {http://dx.doi.org/10.1371/journal.pone.0272984}, keywords = {ventilatory efficiency; cardiovascular complications; peak oxygen consumption}, language = {eng}, issn = {1932-6203}, journal = {PLoS ONE}, title = {Ventilatory efficiency is superior to peak oxygen uptake for prediction of lung resection cardiovascular complications}, url = {https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0272984#abstract0}, volume = {17}, year = {2022} }
TY - JOUR ID - 2234122 AU - Mazúr, Andrej - Brat, Kristián - Homolka, Pavel - Merta, Zdeněk - Svoboda, Michal - Bratová, Monika - Šrámek, Vladimír - Olson, Lyle - Čundrle, Ivan PY - 2022 TI - Ventilatory efficiency is superior to peak oxygen uptake for prediction of lung resection cardiovascular complications JF - PLoS ONE VL - 17 IS - 8 SP - 1-12 EP - 1-12 PB - PUBLIC LIBRARY SCIENCE SN - 19326203 KW - ventilatory efficiency KW - cardiovascular complications KW - peak oxygen consumption UR - https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0272984#abstract0 N2 - Introduction Ventilatory efficiency (VE/VCO2 slope) has been shown superior to peak oxygen consumption (VO2) for prediction of post-operative pulmonary complications in patients undergoing thoracotomy. VE/VCO2 slope is determined by ventilatory drive and ventilation/perfusion mismatch whereas VO2 is related to cardiac output and arteriovenous oxygen difference. We hypothesized pre-operative VO2 predicts post-operative cardiovascular complications in patients undergoing lung resection. Methods Lung resection candidates from a published study were evaluated by post-hoc analysis. All of the patients underwent preoperative cardiopulmonary exercise testing. Post-operative cardiovascular complications were assessed during the first 30 post-operative days or hospital stay. One-way analysis of variance or the Kruskal–Wallis test, and multivariate logistic regression were used for statistical analysis and data summarized as median (IQR). Results Of 353 subjects, 30 (9%) developed pulmonary complications only (excluded from further analysis), while 78 subjects (22%) developed cardiovascular complications and were divided into two groups for analysis: cardiovascular only (n = 49) and cardiovascular with pulmonary complications (n = 29). Compared to patients without complications (n = 245), peak VO2 was significantly lower in the cardiovascular with pulmonary complications group [19.9 ml/kg/min (16.5–25) vs. 16.3 ml/kg/min (15–20.3); P<0.01] but not in the cardiovascular only complications group [19.9 ml/kg/min (16.5–25) vs 19.0 ml/kg/min (16–23.1); P = 0.18]. In contrast, VE/VCO2 slope was significantly higher in both cardiovascular only [29 (25–33) vs. 31 (27–37); P = 0.05] and cardiovascular with pulmonary complication groups [29 (25–33) vs. 37 (34–42); P<0.01)]. Logistic regression analysis showed VE/VCO2 slope [OR = 1.06; 95%CI (1.01–1.11); P = 0.01; AUC = 0.74], but not peak VO2 to be independently associated with post-operative cardiovascular complications. Conclusion VE/VCO2 slope is superior to peak VO2 for prediction of post-operative cardiovascular complications in lung resection candidates. ER -
MAZÚR, Andrej, Kristián BRAT, Pavel HOMOLKA, Zdeněk MERTA, Michal SVOBODA, Monika BRATOVÁ, Vladimír ŠRÁMEK, Lyle OLSON a Ivan ČUNDRLE. Ventilatory efficiency is superior to peak oxygen uptake for prediction of lung resection cardiovascular complications. \textit{PLoS ONE}. SAN FRANCISCO: PUBLIC LIBRARY SCIENCE, 2022, roč.~17, č.~8, s.~1-12. ISSN~1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0272984.
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