Animal models of tick-borne encephalitis for preclinical
antiviral research

C 2022

Animal models of tick-borne encephalitis for preclinical antiviral research

RŮŽEK, Daniel

Basic information

Original name

Animal models of tick-borne encephalitis for preclinical antiviral research

Authors

RŮŽEK, Daniel (203 Czech Republic, guarantor, belonging to the institution)

Edition

Cambridge, Annual Reports in Medicinal Chemistry : Medicinal Chemistry of Tick-Borne Encephalitis, p. 243-256, 14 pp. 58, 2022

Publisher

Elsevier

Other information

Language

English

Type of outcome

Kapitola resp. kapitoly v odborné knize

Field of Study

30310 Parasitology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Publication form

printed version "print"

References:

URL

RIV identification code

RIV/00216224:14310/22:00130085

Organization unit

Faculty of Science

ISBN

978-0-323-98893-3

DOI

http://dx.doi.org/10.1016/bs.armc.2022.08.002

UT WoS

001108640700006

Keywords in English

Tick-borne encephalitis; Animal models; Antivirals; Preclinical testing

Abstract

V originále

Tick-borne encephalitis (TBE), a central nervous system infection caused by the TBE virus (TBEV), is a public health concern in large, forested areas of Europe and Asia. The disease can manifest as a mild, febrile, flu-like illness, but it can also progress to meningitis, encephalitis, or meningoencephalitis. Myelitis and spinal paralysis may also occur. To date, there is no specific drug approved for the treatment of TBE. An essential prerequisite for the development of new specific therapies for TBE is the availability of suitable animal models for TBE. There are several animal models for TBE that include laboratory mice, rats, and nonhuman primates. None of these existing models is ideal for recapitulating all aspects of TBE in humans. Nevertheless, they are useful for studying different aspects of TBE pathogenesis and for testing and developing new therapeutic countermeasures.

Citovat

RŮŽEK, Daniel. Animal models of tick-borne encephalitis for preclinical antiviral research. In Annual Reports in Medicinal Chemistry : Medicinal Chemistry of Tick-Borne Encephalitis. Cambridge: Elsevier, 2022, p. 243-256. 58. ISBN 978-0-323-98893-3. Available from: https://dx.doi.org/10.1016/bs.armc.2022.08.002.

@inbook{2234537,
   author = {Růžek, Daniel},
   address = {Cambridge},
   booktitle = {Annual Reports in Medicinal Chemistry : Medicinal Chemistry of Tick-Borne Encephalitis},
   doi = {http://dx.doi.org/10.1016/bs.armc.2022.08.002},
   keywords = {Tick-borne encephalitis; Animal models; Antivirals; Preclinical testing},
   howpublished = {tištěná verze "print"},
   language = {eng},
   location = {Cambridge},
   isbn = {978-0-323-98893-3},
   pages = {243-256},
   publisher = {Elsevier},
   title = {Animal models of tick-borne encephalitis for preclinical antiviral research},
   url = {https://doi.org/10.1016/bs.armc.2022.08.002},
   year = {2022}
}

TY  - CHAP
ID  - 2234537
AU  - Růžek, Daniel
PY  - 2022
TI  - Animal models of tick-borne encephalitis for preclinical antiviral research
VL  - 58
PB  - Elsevier
CY  - Cambridge
SN  - 9780323988933
KW  - Tick-borne encephalitis
KW  - Animal models
KW  - Antivirals
KW  - Preclinical testing
UR  - https://doi.org/10.1016/bs.armc.2022.08.002
N2  - Tick-borne encephalitis (TBE), a central nervous system infection caused by the TBE virus (TBEV), is a public health concern in large, forested areas of Europe and Asia. The disease can manifest as a mild, febrile, flu-like illness, but it can also progress to meningitis, encephalitis, or meningoencephalitis. Myelitis and spinal paralysis may also occur. To date, there is no specific drug approved for the treatment of TBE. An essential prerequisite for the development of new specific therapies for TBE is the availability of suitable animal models for TBE. There are several animal models for TBE that include laboratory mice, rats, and nonhuman primates. None of these existing models is ideal for recapitulating all aspects of TBE in humans. Nevertheless, they are useful for studying different aspects of TBE pathogenesis and for testing and developing new therapeutic countermeasures.
ER  -

RŮŽEK, Daniel. Animal models of tick-borne encephalitis for preclinical antiviral research. In \textit{Annual Reports in Medicinal Chemistry : Medicinal Chemistry of Tick-Borne Encephalitis}. Cambridge: Elsevier, 2022, p.~243-256. 58. ISBN~978-0-323-98893-3. Available from: https://dx.doi.org/10.1016/bs.armc.2022.08.002.

Detailed Information on Publication Record