In vivo and in vitro effects of salidroside on liver cytochrome P450

KLÁSKOVÁ, Eva, Jan JUŘICA, Tomáš HAMMER, Alena MÁCHALOVÁ, Natálie MLČŮCHOVÁ, Kateřina VYKLICKÁ, Petra BRENEROVÁ, Petra BOŘILOVÁ LINHARTOVÁ and Ondřej ZENDULKA. In vivo and in vitro effects of salidroside on liver cytochrome P450. In 19th International Medical Postgraduate Conference, From Bench to Bedside in PhD Research Projects. 2022.

Basic information

• Original name: In vivo and in vitro effects of salidroside on liver cytochrome P450
• Authors: KLÁSKOVÁ, Eva (203 Czech Republic, guarantor, belonging to the institution), Jan JUŘICA (203 Czech Republic, belonging to the institution), Tomáš HAMMER (203 Czech Republic, belonging to the institution), Alena MÁCHALOVÁ (203 Czech Republic, belonging to the institution), Natálie MLČŮCHOVÁ (203 Czech Republic), Kateřina VYKLICKÁ (203 Czech Republic, belonging to the institution), Petra BRENEROVÁ (203 Czech Republic, belonging to the institution), Petra BOŘILOVÁ LINHARTOVÁ (203 Czech Republic, belonging to the institution) and Ondřej ZENDULKA (203 Czech Republic, belonging to the institution).
• Edition: 19th International Medical Postgraduate Conference, From Bench to Bedside in PhD Research Projects, 2022.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 30104 Pharmacology and pharmacy
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• WWW: Abstract book
• RIV identification code: RIV/00216224:14110/22:00127282
• Organization unit: Faculty of Medicine
• Keywords in English: cytochrome P450; salidroside; metabolic activity; drug-drug interactions

Abstract

Salidroside (SAL) is one of the main active compounds of Rhodiola rosea, a herb with antidepressant and anxiolytic potential proven by clinical studies. Cytochromes P450 (CYP) are enzymes responsible for the metabolism of 70-80 % of medicaments in clinical practice. Since R. rosea is the ingredient of various over-the-counter food supplements, we have focused on its potential for pharmacokinetic interactions with the most important CYP isoforms.

Links

• LM2018121, research and development project: Name: Výzkumná infrastruktura RECETOX (Acronym: RECETOX RI)

Investor: Ministry of Education, Youth and Sports of the CR, RECETOX RI

• MUNI/A/1440/2021, interní kód MU: Name: Preklinický a klinický výzkum Farmakologického ústavu v oblasti farmakokinetiky, neurobiologie závislostí a personalizované farmakoterapie v onkologii (Acronym: Farm-Pre-Klin)

Investor: Masaryk University

• MUNI/IGA/1261/2020, interní kód MU: Name: The influence of promising herbal antidepressant salidroside on drug metabolizing enzymes

Investor: Masaryk University