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@proceedings{2235181, author = {Klásková, Eva and Juřica, Jan and Hammer, Tomáš and Máchalová, Alena and Mlčůchová, Natálie and Vyklická, Kateřina and Brenerová, Petra and Bořilová Linhartová, Petra and Zendulka, Ondřej}, booktitle = {19th International Medical Postgraduate Conference, From Bench to Bedside in PhD Research Projects}, keywords = {cytochrome P450; salidroside; metabolic activity; drug-drug interactions}, language = {eng}, title = {In vivo and in vitro effects of salidroside on liver cytochrome P450}, url = {https://www.lfhk.cuni.cz/getattachment/Veda,-zahranici/Vedecka-setkani/Mezinarodni-konference-studentu-DSP/Archiv-mezinarodnich-konferenci-studentu-DSP/Abstracts_19th_IMPC_2022.pdf.aspx/?lang=en-GB}, year = {2022} }
TY - CONF ID - 2235181 AU - Klásková, Eva - Juřica, Jan - Hammer, Tomáš - Máchalová, Alena - Mlčůchová, Natálie - Vyklická, Kateřina - Brenerová, Petra - Bořilová Linhartová, Petra - Zendulka, Ondřej PY - 2022 TI - In vivo and in vitro effects of salidroside on liver cytochrome P450 KW - cytochrome P450 KW - salidroside KW - metabolic activity KW - drug-drug interactions UR - https://www.lfhk.cuni.cz/getattachment/Veda,-zahranici/Vedecka-setkani/Mezinarodni-konference-studentu-DSP/Archiv-mezinarodnich-konferenci-studentu-DSP/Abstracts_19th_IMPC_2022.pdf.aspx/?lang=en-GB N2 - Salidroside (SAL) is one of the main active compounds of Rhodiola rosea, a herb with antidepressant and anxiolytic potential proven by clinical studies. Cytochromes P450 (CYP) are enzymes responsible for the metabolism of 70-80 % of medicaments in clinical practice. Since R. rosea is the ingredient of various over-the-counter food supplements, we have focused on its potential for pharmacokinetic interactions with the most important CYP isoforms. ER -
KLÁSKOVÁ, Eva, Jan JUŘICA, Tomáš HAMMER, Alena MÁCHALOVÁ, Natálie MLČŮCHOVÁ, Kateřina VYKLICKÁ, Petra BRENEROVÁ, Petra BOŘILOVÁ LINHARTOVÁ and Ondřej ZENDULKA. In vivo and in vitro effects of salidroside on liver cytochrome P450. In \textit{19th International Medical Postgraduate Conference, From Bench to Bedside in PhD Research Projects}. 2022.
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