Lifespan and telomere length variation across populations of
wild-derived African killifish

J 2022

Lifespan and telomere length variation across populations of wild-derived African killifish

REICHARD, Martin, Kety GIANNETTI, Tania FERREIRA, Ahmed MAOUCHE, Milan VRTILEK et. al.

Basic information

Original name

Lifespan and telomere length variation across populations of wild-derived African killifish

Authors

REICHARD, Martin (203 Czech Republic, guarantor, belonging to the institution), Kety GIANNETTI, Tania FERREIRA, Ahmed MAOUCHE, Milan VRTILEK, Matej POLACIK, Radim BLAZEK and Miguel Godinho FERREIRA

Edition

Molecular Ecology, Wiley, 2022, 0962-1083

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10602 Biology , Evolutionary biology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.900

RIV identification code

RIV/00216224:14310/22:00127324

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1111/mec.16287

UT WoS

000727399500001

Keywords in English

comparative biology; fish; inter-population gradient; sex differences telomeres

Abstract

V originále

Telomeres and telomerase prevent the continuous erosion of chromosome-ends caused by lifelong cell division. Shortened telomeres are associated with age-related pathologies. While short telomere length is positively correlated with increased lethality at the individual level, in comparisons across species short telomeres are associated with long (and not short) lifespans. Here, we tested this contradiction between individual and evolutionary patterns in telomere length using African annual killifish. We analysed lifespan and telomere length in a set of captive strains derived from well-defined wild populations of Nothobranchius furzeri and its sister species, N. kadleci, from sites along a strong gradient of aridity which ultimately determines maximum natural lifespan. Overall, males were shorter-lived than females, and also had shorter telomeres. Male lifespan (measured in controlled laboratory conditions) was positively associated with the amount of annual rainfall in the site of strain origin. However, fish from wetter climates had shorter telomeres. In addition, individual fish which grew largest over the juvenile period possessed shorter telomeres at the onset of adulthood. This demonstrates that individual condition and environmentally-driven selection indeed modulate the relationship between telomere length and lifespan in opposite directions, validating the existence of inverse trends within a single taxon. Intraindividual heterogeneity of telomere length (capable to detect very short telomeres) was not associated with mean telomere length, suggesting that the shortest telomeres are controlled by regulatory pathways other than those that determine mean telomere length. The substantial variation in telomere length between strains from different environments identifies killifish as a powerful system in understanding the adaptive value of telomere length.

Citovat

REICHARD, Martin, Kety GIANNETTI, Tania FERREIRA, Ahmed MAOUCHE, Milan VRTILEK, Matej POLACIK, Radim BLAZEK and Miguel Godinho FERREIRA. Lifespan and telomere length variation across populations of wild-derived African killifish. Molecular Ecology. Wiley, 2022, vol. 31, No 23, p. 5979-5992. ISSN 0962-1083. Available from: https://dx.doi.org/10.1111/mec.16287.

@article{2236159,
   author = {Reichard, Martin and Giannetti, Kety and Ferreira, Tania and Maouche, Ahmed and Vrtilek, Milan and Polacik, Matej and Blazek, Radim and Ferreira, Miguel Godinho},
   article_number = {23},
   doi = {http://dx.doi.org/10.1111/mec.16287},
   keywords = {comparative biology; fish; inter-population gradient; sex differences telomeres},
   language = {eng},
   issn = {0962-1083},
   journal = {Molecular Ecology},
   title = {Lifespan and telomere length variation across populations of wild-derived African killifish},
   url = {https://doi.org/10.1111/mec.16287},
   volume = {31},
   year = {2022}
}

TY  - JOUR
ID  - 2236159
AU  - Reichard, Martin - Giannetti, Kety - Ferreira, Tania - Maouche, Ahmed - Vrtilek, Milan - Polacik, Matej - Blazek, Radim - Ferreira, Miguel Godinho
PY  - 2022
TI  - Lifespan and telomere length variation across populations of wild-derived African killifish
JF  - Molecular Ecology
VL  - 31
IS  - 23
SP  - 5979-5992
EP  - 5979-5992
PB  - Wiley
SN  - 09621083
KW  - comparative biology
KW  - fish
KW  - inter-population gradient
KW  - sex differences telomeres
UR  - https://doi.org/10.1111/mec.16287
N2  - Telomeres and telomerase prevent the continuous erosion of chromosome-ends caused by lifelong cell division. Shortened telomeres are associated with age-related pathologies. While short telomere length is positively correlated with increased lethality at the individual level, in comparisons across species short telomeres are associated with long (and not short) lifespans. Here, we tested this contradiction between individual and evolutionary patterns in telomere length using African annual killifish. We analysed lifespan and telomere length in a set of captive strains derived from well-defined wild populations of Nothobranchius furzeri and its sister species, N. kadleci, from sites along a strong gradient of aridity which ultimately determines maximum natural lifespan. Overall, males were shorter-lived than females, and also had shorter telomeres. Male lifespan (measured in controlled laboratory conditions) was positively associated with the amount of annual rainfall in the site of strain origin. However, fish from wetter climates had shorter telomeres. In addition, individual fish which grew largest over the juvenile period possessed shorter telomeres at the onset of adulthood. This demonstrates that individual condition and environmentally-driven selection indeed modulate the relationship between telomere length and lifespan in opposite directions, validating the existence of inverse trends within a single taxon. Intraindividual heterogeneity of telomere length (capable to detect very short telomeres) was not associated with mean telomere length, suggesting that the shortest telomeres are controlled by regulatory pathways other than those that determine mean telomere length. The substantial variation in telomere length between strains from different environments identifies killifish as a powerful system in understanding the adaptive value of telomere length.
ER  -

REICHARD, Martin, Kety GIANNETTI, Tania FERREIRA, Ahmed MAOUCHE, Milan VRTILEK, Matej POLACIK, Radim BLAZEK and Miguel Godinho FERREIRA. Lifespan and telomere length variation across populations of wild-derived African killifish. \textit{Molecular Ecology}. Wiley, 2022, vol.~31, No~23, p.~5979-5992. ISSN~0962-1083. Available from: https://dx.doi.org/10.1111/mec.16287.

Detailed Information on Publication Record