Inter-individual differences in baseline dynamic functional connectivity are linked to cognitive aftereffects of tDCS

PUPÍKOVÁ, Monika, Patrik ŠIMKO, Martin LAMOŠ, Martin GAJDOŠ and Irena REKTOROVÁ. Inter-individual differences in baseline dynamic functional connectivity are linked to cognitive aftereffects of tDCS. Scientific Reports. Berlin: Springer Nature, 2022, vol. 12, No 1, p. 1-12. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/s41598-022-25016-5.

Basic information

• Original name: Inter-individual differences in baseline dynamic functional connectivity are linked to cognitive aftereffects of tDCS
• Authors: PUPÍKOVÁ, Monika (203 Czech Republic, belonging to the institution), Patrik ŠIMKO (703 Slovakia, belonging to the institution), Martin LAMOŠ (203 Czech Republic, belonging to the institution), Martin GAJDOŠ (203 Czech Republic, belonging to the institution) and Irena REKTOROVÁ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Scientific Reports, Berlin, Springer Nature, 2022, 2045-2322.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30210 Clinical neurology
• Country of publisher: Germany
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 4.600
• RIV identification code: RIV/00216224:14740/22:00127330
• Organization unit: Central European Institute of Technology
• Doi: http://dx.doi.org/10.1038/s41598-022-25016-5
• UT WoS: 000914086600057
• Keywords in English: tDCS; baseline dynamic functional connectivity
• Tags: 14110127, 14110132, CF MAFIL, podil
• Tags: International impact, Reviewed

Abstract

Transcranial direct current stimulation (tDCS) has the potential to modulate cognitive training in healthy aging; however, results from various studies have been inconsistent. We hypothesized that inter-individual differences in baseline brain state may contribute to the varied results. We aimed to explore whether baseline resting-state dynamic functional connectivity (rs-dFC) and/or conventional resting-state static functional connectivity (rs-sFC) may be related to the magnitude of cognitive aftereffects of tDCS. To achieve this aim, we used data from our double-blind randomized sham-controlled cross-over tDCS trial in 25 healthy seniors in which bifrontal tDCS combined with cognitive training had induced significant behavioral aftereffects. We performed a backward regression analysis including rs-sFC/rs-dFC measures to explain the variability in the magnitude of tDCS-induced improvements in visual object-matching task (VOMT) accuracy. Rs-dFC analysis revealed four rs-dFC states. The occurrence rate of a rs-dFC state 4, characterized by a high correlation between the left fronto-parietal control network and the language network, was significantly associated with tDCS-induced VOMT accuracy changes. The rs-sFC measure was not significantly associated with the cognitive outcome. We show that flexibility of the brain state representing readiness for top-down control of object identification implicated in the studied task is linked to the tDCS-enhanced task accuracy.

Links

• LM2018129, research and development project: Name: Národní infrastruktura pro biologické a medicínské zobrazování Czech-BioImaging

Investor: Ministry of Education, Youth and Sports of the CR

• MUNI/A/1155/2021, interní kód MU: Name: Analýza kognice a vědomí pomocí funkčních metod

Investor: Masaryk University

• NV18-04-00256, research and development project: Name: Efekt transkraniální stimulace tDCS na zrakovou pozornost u pacientů s mírnou kognitivní poruchou - studie kombinující MRI a neinvazivní mozkovou stimulaci

Investor: Ministry of Health of the CR