Inter-individual differences in baseline dynamic functional
connectivity are linked to cognitive aftereffects of tDCS

J 2022

Inter-individual differences in baseline dynamic functional connectivity are linked to cognitive aftereffects of tDCS

PUPÍKOVÁ, Monika; Patrik ŠIMKO; Martin LAMOŠ; Martin GAJDOŠ; Irena REKTOROVÁ et. al.

Basic information

Original name

Inter-individual differences in baseline dynamic functional connectivity are linked to cognitive aftereffects of tDCS

Authors

PUPÍKOVÁ, Monika (203 Czech Republic, belonging to the institution); Patrik ŠIMKO (703 Slovakia, belonging to the institution); Martin LAMOŠ (203 Czech Republic, belonging to the institution); Martin GAJDOŠ (203 Czech Republic, belonging to the institution) and Irena REKTOROVÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Scientific Reports, Berlin, Springer Nature, 2022, 2045-2322

Other information

Language

English

Type of outcome

Article in a journal

Field of Study

30210 Clinical neurology

Country of publisher

Germany

Confidentiality degree

is not subject to a state or trade secret

References:

URL

Impact factor

Impact factor: 4.600

RIV identification code

RIV/00216224:14740/22:00127330

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1038/s41598-022-25016-5

UT WoS

000914086600057

EID Scopus

2-s2.0-85143184217

Keywords in English

tDCS; baseline dynamic functional connectivity

Abstract

V originále

Transcranial direct current stimulation (tDCS) has the potential to modulate cognitive training in healthy aging; however, results from various studies have been inconsistent. We hypothesized that inter-individual differences in baseline brain state may contribute to the varied results. We aimed to explore whether baseline resting-state dynamic functional connectivity (rs-dFC) and/or conventional resting-state static functional connectivity (rs-sFC) may be related to the magnitude of cognitive aftereffects of tDCS. To achieve this aim, we used data from our double-blind randomized sham-controlled cross-over tDCS trial in 25 healthy seniors in which bifrontal tDCS combined with cognitive training had induced significant behavioral aftereffects. We performed a backward regression analysis including rs-sFC/rs-dFC measures to explain the variability in the magnitude of tDCS-induced improvements in visual object-matching task (VOMT) accuracy. Rs-dFC analysis revealed four rs-dFC states. The occurrence rate of a rs-dFC state 4, characterized by a high correlation between the left fronto-parietal control network and the language network, was significantly associated with tDCS-induced VOMT accuracy changes. The rs-sFC measure was not significantly associated with the cognitive outcome. We show that flexibility of the brain state representing readiness for top-down control of object identification implicated in the studied task is linked to the tDCS-enhanced task accuracy.

Links

MUNI/A/1155/2021, interní kód MU

Name: Analýza kognice a vědomí pomocí funkčních metod

Investor: Masaryk University

NV18-04-00256, research and development project

Name: Efekt transkraniální stimulace tDCS na zrakovou pozornost u pacientů s mírnou kognitivní poruchou - studie kombinující MRI a neinvazivní mozkovou stimulaci

Investor: Ministry of Health of the CR

90129, large research infrastructures

Name: Czech-BioImaging II

Cite

PUPÍKOVÁ, Monika; Patrik ŠIMKO; Martin LAMOŠ; Martin GAJDOŠ and Irena REKTOROVÁ. Inter-individual differences in baseline dynamic functional connectivity are linked to cognitive aftereffects of tDCS. Scientific Reports. Berlin: Springer Nature, 2022, vol. 12, No 1, p. 1-12. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/s41598-022-25016-5.

@article{2236213,
   author = {Pupíková, Monika and Šimko, Patrik and Lamoš, Martin and Gajdoš, Martin and Rektorová, Irena},
   article_location = {Berlin},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/s41598-022-25016-5},
   keywords = {tDCS; baseline dynamic functional connectivity},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific Reports},
   title = {Inter-individual differences in baseline dynamic functional connectivity are linked to cognitive aftereffects of tDCS},
   url = {https://www.nature.com/articles/s41598-022-25016-5},
   volume = {12},
   year = {2022}
}

TY  - JOUR
ID  - 2236213
AU  - Pupíková, Monika - Šimko, Patrik - Lamoš, Martin - Gajdoš, Martin - Rektorová, Irena
PY  - 2022
TI  - Inter-individual differences in baseline dynamic functional connectivity are linked to cognitive aftereffects of tDCS
JF  - Scientific Reports
VL  - 12
IS  - 1
SP  - 1-12
EP  - 1-12
PB  - Springer Nature
SN  - 20452322
KW  - tDCS
KW  - baseline dynamic functional connectivity
UR  - https://www.nature.com/articles/s41598-022-25016-5
N2  - Transcranial direct current stimulation (tDCS) has the potential to modulate cognitive training in healthy aging; however, results from various studies have been inconsistent. We hypothesized that inter-individual differences in baseline brain state may contribute to the varied results. We aimed to explore whether baseline resting-state dynamic functional connectivity (rs-dFC) and/or conventional resting-state static functional connectivity (rs-sFC) may be related to the magnitude of cognitive aftereffects of tDCS. To achieve this aim, we used data from our double-blind randomized sham-controlled cross-over tDCS trial in 25 healthy seniors in which bifrontal tDCS combined with cognitive training had induced significant behavioral aftereffects. We performed a backward regression analysis including rs-sFC/rs-dFC measures to explain the variability in the magnitude of tDCS-induced improvements in visual object-matching task (VOMT) accuracy. Rs-dFC analysis revealed four rs-dFC states. The occurrence rate of a rs-dFC state 4, characterized by a high correlation between the left fronto-parietal control network and the language network, was significantly associated with tDCS-induced VOMT accuracy changes. The rs-sFC measure was not significantly associated with the cognitive outcome. We show that flexibility of the brain state representing readiness for top-down control of object identification implicated in the studied task is linked to the tDCS-enhanced task accuracy.
ER  -

PUPÍKOVÁ, Monika; Patrik ŠIMKO; Martin LAMOŠ; Martin GAJDOŠ and Irena REKTOROVÁ. Inter-individual differences in baseline dynamic functional connectivity are linked to cognitive aftereffects of tDCS. \textit{Scientific Reports}. Berlin: Springer Nature, 2022, vol.~12, No~1, p.~1-12. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-022-25016-5.

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