Inter-individual differences in baseline dynamic functional
connectivity are linked to cognitive aftereffects of tDCS

J 2022

Inter-individual differences in baseline dynamic functional connectivity are linked to cognitive aftereffects of tDCS

PUPÍKOVÁ, Monika, Patrik ŠIMKO, Martin LAMOŠ, Martin GAJDOŠ, Irena REKTOROVÁ et. al.

Basic information

Original name

Inter-individual differences in baseline dynamic functional connectivity are linked to cognitive aftereffects of tDCS

Authors

PUPÍKOVÁ, Monika (203 Czech Republic, belonging to the institution), Patrik ŠIMKO (703 Slovakia, belonging to the institution), Martin LAMOŠ (203 Czech Republic, belonging to the institution), Martin GAJDOŠ (203 Czech Republic, belonging to the institution) and Irena REKTOROVÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Scientific Reports, Berlin, Springer Nature, 2022, 2045-2322

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.600

RIV identification code

RIV/00216224:14740/22:00127330

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1038/s41598-022-25016-5

UT WoS

000914086600057

Keywords in English

tDCS; baseline dynamic functional connectivity

Abstract

V originále

Transcranial direct current stimulation (tDCS) has the potential to modulate cognitive training in healthy aging; however, results from various studies have been inconsistent. We hypothesized that inter-individual differences in baseline brain state may contribute to the varied results. We aimed to explore whether baseline resting-state dynamic functional connectivity (rs-dFC) and/or conventional resting-state static functional connectivity (rs-sFC) may be related to the magnitude of cognitive aftereffects of tDCS. To achieve this aim, we used data from our double-blind randomized sham-controlled cross-over tDCS trial in 25 healthy seniors in which bifrontal tDCS combined with cognitive training had induced significant behavioral aftereffects. We performed a backward regression analysis including rs-sFC/rs-dFC measures to explain the variability in the magnitude of tDCS-induced improvements in visual object-matching task (VOMT) accuracy. Rs-dFC analysis revealed four rs-dFC states. The occurrence rate of a rs-dFC state 4, characterized by a high correlation between the left fronto-parietal control network and the language network, was significantly associated with tDCS-induced VOMT accuracy changes. The rs-sFC measure was not significantly associated with the cognitive outcome. We show that flexibility of the brain state representing readiness for top-down control of object identification implicated in the studied task is linked to the tDCS-enhanced task accuracy.

Links

MUNI/A/1155/2021, interní kód MU

Name: Analýza kognice a vědomí pomocí funkčních metod

Investor: Masaryk University

NV18-04-00256, research and development project

Name: Efekt transkraniální stimulace tDCS na zrakovou pozornost u pacientů s mírnou kognitivní poruchou - studie kombinující MRI a neinvazivní mozkovou stimulaci

Investor: Ministry of Health of the CR

90129, large research infrastructures

Name: Czech-BioImaging II

Citovat

PUPÍKOVÁ, Monika, Patrik ŠIMKO, Martin LAMOŠ, Martin GAJDOŠ and Irena REKTOROVÁ. Inter-individual differences in baseline dynamic functional connectivity are linked to cognitive aftereffects of tDCS. Scientific Reports. Berlin: Springer Nature, 2022, vol. 12, No 1, p. 1-12. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/s41598-022-25016-5.

@article{2236213,
   author = {Pupíková, Monika and Šimko, Patrik and Lamoš, Martin and Gajdoš, Martin and Rektorová, Irena},
   article_location = {Berlin},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/s41598-022-25016-5},
   keywords = {tDCS; baseline dynamic functional connectivity},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific Reports},
   title = {Inter-individual differences in baseline dynamic functional connectivity are linked to cognitive aftereffects of tDCS},
   url = {https://www.nature.com/articles/s41598-022-25016-5},
   volume = {12},
   year = {2022}
}

TY  - JOUR
ID  - 2236213
AU  - Pupíková, Monika - Šimko, Patrik - Lamoš, Martin - Gajdoš, Martin - Rektorová, Irena
PY  - 2022
TI  - Inter-individual differences in baseline dynamic functional connectivity are linked to cognitive aftereffects of tDCS
JF  - Scientific Reports
VL  - 12
IS  - 1
SP  - 1-12
EP  - 1-12
PB  - Springer Nature
SN  - 20452322
KW  - tDCS
KW  - baseline dynamic functional connectivity
UR  - https://www.nature.com/articles/s41598-022-25016-5
N2  - Transcranial direct current stimulation (tDCS) has the potential to modulate cognitive training in healthy aging; however, results from various studies have been inconsistent. We hypothesized that inter-individual differences in baseline brain state may contribute to the varied results. We aimed to explore whether baseline resting-state dynamic functional connectivity (rs-dFC) and/or conventional resting-state static functional connectivity (rs-sFC) may be related to the magnitude of cognitive aftereffects of tDCS. To achieve this aim, we used data from our double-blind randomized sham-controlled cross-over tDCS trial in 25 healthy seniors in which bifrontal tDCS combined with cognitive training had induced significant behavioral aftereffects. We performed a backward regression analysis including rs-sFC/rs-dFC measures to explain the variability in the magnitude of tDCS-induced improvements in visual object-matching task (VOMT) accuracy. Rs-dFC analysis revealed four rs-dFC states. The occurrence rate of a rs-dFC state 4, characterized by a high correlation between the left fronto-parietal control network and the language network, was significantly associated with tDCS-induced VOMT accuracy changes. The rs-sFC measure was not significantly associated with the cognitive outcome. We show that flexibility of the brain state representing readiness for top-down control of object identification implicated in the studied task is linked to the tDCS-enhanced task accuracy.
ER  -

PUPÍKOVÁ, Monika, Patrik ŠIMKO, Martin LAMOŠ, Martin GAJDOŠ and Irena REKTOROVÁ. Inter-individual differences in baseline dynamic functional connectivity are linked to cognitive aftereffects of tDCS. \textit{Scientific Reports}. Berlin: Springer Nature, 2022, vol.~12, No~1, p.~1-12. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-022-25016-5.

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