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@article{2237540,
author = {Šimko, Patrik and Kent, Julia Anna and Rektorová, Irena},
article_location = {Clare},
article_number = {DEC},
doi = {http://dx.doi.org/10.1016/j.clinph.2022.09.010},
keywords = {Brain stimulation; Noninvasive; tDCS; rTMS; Dementia; Alzheimer?s disease; Mild cognitive impairment; MCI},
language = {eng},
issn = {1388-2457},
journal = {Clinical Neurophysiology},
title = {Is non-invasive brain stimulation effective for cognitive enhancement in Alzheimer?s disease? An updated meta-analysis},
url = {https://www.sciencedirect.com/science/article/pii/S1388245722008975?via%3Dihub},
volume = {144},
year = {2022}
}
TY - JOUR
ID - 2237540
AU - Šimko, Patrik - Kent, Julia Anna - Rektorová, Irena
PY - 2022
TI - Is non-invasive brain stimulation effective for cognitive enhancement in Alzheimer?s disease? An updated meta-analysis
JF - Clinical Neurophysiology
VL - 144
IS - DEC
SP - 23-40
EP - 23-40
PB - Elsevier Ireland
SN - 13882457
KW - Brain stimulation
KW - Noninvasive
KW - tDCS
KW - rTMS
KW - Dementia
KW - Alzheimer?s disease
KW - Mild cognitive impairment
KW - MCI
UR - https://www.sciencedirect.com/science/article/pii/S1388245722008975?via%3Dihub
N2 - Objective: Alzheimer's disease dementia (AD) and its preclinical stage, mild cognitive impairment (MCI), are critical issues confronting the aging society. Non-invasive brain stimulation (NIBS) techniques have the potential to be effective tools for enhancing cognitive functioning. The main objective of our meta -analysis was to quantify and update the status of the efficacy of repetitive Transcranial Magnetic Stimulation (rTMS) and Transcranial Direct Current Stimulation (tDCS) when applied in AD and MCI.Methods: The systematic literature search was conducted in PubMed and Web of Science according to PRISMA statement.Results: Pooled effect sizes (Hedges' g) from 32 studies were analyzed using random effect models. We found both, rTMS and tDCS to have significant immediate cognition-enhancing effect in AD with rTMS inducing also beneficial long-term effects. We found no evidence for synergistic effect of cognitive train-ing with NIBS.Conclusions: In AD a clinical recommendation can be made for NEURO-ADTM system and for high -frequency rTMS over the left dorsolateral prefrontal cortex (DLPFC) as probably effective protocols (B -level of evidence) and for anodal tDCS over the left DLPFC as a possibly effective.Significance: According to scientific literature, NIBS may be an effective method for improving cognition in AD and possibly in MCI.(c) 2022 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
ER -
ŠIMKO, Patrik, Julia Anna KENT and Irena REKTOROVÁ. Is non-invasive brain stimulation effective for cognitive enhancement in Alzheimer?s disease? An updated meta-analysis. \textit{Clinical Neurophysiology}. Clare: Elsevier Ireland, vol.~144, DEC, p.~23-40. ISSN~1388-2457. doi:10.1016/j.clinph.2022.09.010. 2022.
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