Detailed Information on Publication Record
2022
Is non-invasive brain stimulation effective for cognitive enhancement in Alzheimer?s disease? An updated meta-analysis
ŠIMKO, Patrik, Julia Anna KENT and Irena REKTOROVÁBasic information
Original name
Is non-invasive brain stimulation effective for cognitive enhancement in Alzheimer?s disease? An updated meta-analysis
Authors
ŠIMKO, Patrik (703 Slovakia, belonging to the institution), Julia Anna KENT (203 Czech Republic, belonging to the institution) and Irena REKTOROVÁ (203 Czech Republic, guarantor, belonging to the institution)
Edition
Clinical Neurophysiology, Clare, Elsevier Ireland, 2022, 1388-2457
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30103 Neurosciences
Country of publisher
Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 4.700
RIV identification code
RIV/00216224:14740/22:00129715
Organization unit
Central European Institute of Technology
UT WoS
000886064800004
Keywords in English
Brain stimulation; Noninvasive; tDCS; rTMS; Dementia; Alzheimer?s disease; Mild cognitive impairment; MCI
Tags
International impact, Reviewed
Změněno: 13/12/2022 14:12, Mgr. Pavla Foltynová, Ph.D.
Abstract
V originále
Objective: Alzheimer's disease dementia (AD) and its preclinical stage, mild cognitive impairment (MCI), are critical issues confronting the aging society. Non-invasive brain stimulation (NIBS) techniques have the potential to be effective tools for enhancing cognitive functioning. The main objective of our meta -analysis was to quantify and update the status of the efficacy of repetitive Transcranial Magnetic Stimulation (rTMS) and Transcranial Direct Current Stimulation (tDCS) when applied in AD and MCI.Methods: The systematic literature search was conducted in PubMed and Web of Science according to PRISMA statement.Results: Pooled effect sizes (Hedges' g) from 32 studies were analyzed using random effect models. We found both, rTMS and tDCS to have significant immediate cognition-enhancing effect in AD with rTMS inducing also beneficial long-term effects. We found no evidence for synergistic effect of cognitive train-ing with NIBS.Conclusions: In AD a clinical recommendation can be made for NEURO-ADTM system and for high -frequency rTMS over the left dorsolateral prefrontal cortex (DLPFC) as probably effective protocols (B -level of evidence) and for anodal tDCS over the left DLPFC as a possibly effective.Significance: According to scientific literature, NIBS may be an effective method for improving cognition in AD and possibly in MCI.(c) 2022 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Links
NV18-04-00256, research and development project |
|