Prolonged survival in patients with local chronic infection
after high-grade glioma treatment: two case reports

J 2022

Prolonged survival in patients with local chronic infection after high-grade glioma treatment: two case reports

SOLÁR, Peter, Zdeněk MACKERLE, Michal HENDRYCH, Petr POSPÍŠIL, Radek LAKOMÝ et. al.

Basic information

Original name

Prolonged survival in patients with local chronic infection after high-grade glioma treatment: two case reports

Authors

SOLÁR, Peter (703 Slovakia, belonging to the institution), Zdeněk MACKERLE (203 Czech Republic, belonging to the institution), Michal HENDRYCH (203 Czech Republic, belonging to the institution), Petr POSPÍŠIL (203 Czech Republic, belonging to the institution), Radek LAKOMÝ (203 Czech Republic, belonging to the institution), Hana VALEKOVÁ (703 Slovakia, belonging to the institution), Markéta HERMANOVÁ (203 Czech Republic, belonging to the institution) and Radim JANČÁLEK (203 Czech Republic, guarantor, belonging to the institution)

Edition

FRONTIERS IN ONCOLOGY, LAUSANNE, FRONTIERS MEDIA SA, 2022, 2234-943X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.700

RIV identification code

RIV/00216224:14110/22:00127373

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3389/fonc.2022.1073036

UT WoS

000904981000001

Keywords in English

high-grade glioma; glioblastoma; anaplastic astrocytoma; wound infection; prolonged survival

Abstract

V originále

High-grade gliomas are primary brain tumors with poor prognosis, despite surgical treatment followed by radiotherapy and concomitant chemotherapy. We present two cases of long-term survival in patients treated for high-grade glioma and concomitant prolonged bacterial wound infection. The first patient treated for glioblastoma IDH-wildtype had been without disease progression for 61 months from the first resected recurrence. Despite incomplete chemotherapy-induced myelosuppression in the second patient with anaplastic astrocytoma IDH-mutant, she died without disease relapse after 14 years from the diagnosis due to other comorbidities. We assume that the documented prolonged survival could be related to the bacterial infection.

Links

MUNI/A/1408/2021, interní kód MU

Name: Organotypické kultury glioblastomu – personalizované testování protinádorové léčby

Investor: Masaryk University

Citovat

SOLÁR, Peter, Zdeněk MACKERLE, Michal HENDRYCH, Petr POSPÍŠIL, Radek LAKOMÝ, Hana VALEKOVÁ, Markéta HERMANOVÁ and Radim JANČÁLEK. Prolonged survival in patients with local chronic infection after high-grade glioma treatment: two case reports. FRONTIERS IN ONCOLOGY. LAUSANNE: FRONTIERS MEDIA SA, 2022, vol. 12, December 2022, p. 1-7. ISSN 2234-943X. Available from: https://dx.doi.org/10.3389/fonc.2022.1073036.

@article{2237877,
   author = {Solár, Peter and Mackerle, Zdeněk and Hendrych, Michal and Pospíšil, Petr and Lakomý, Radek and Valeková, Hana and Hermanová, Markéta and Jančálek, Radim},
   article_location = {LAUSANNE},
   article_number = {December 2022},
   doi = {http://dx.doi.org/10.3389/fonc.2022.1073036},
   keywords = {high-grade glioma; glioblastoma; anaplastic astrocytoma; wound infection; prolonged survival},
   language = {eng},
   issn = {2234-943X},
   journal = {FRONTIERS IN ONCOLOGY},
   title = {Prolonged survival in patients with local chronic infection after high-grade glioma treatment: two case reports},
   url = {https://www.frontiersin.org/articles/10.3389/fonc.2022.1073036/full},
   volume = {12},
   year = {2022}
}

TY  - JOUR
ID  - 2237877
AU  - Solár, Peter - Mackerle, Zdeněk - Hendrych, Michal - Pospíšil, Petr - Lakomý, Radek - Valeková, Hana - Hermanová, Markéta - Jančálek, Radim
PY  - 2022
TI  - Prolonged survival in patients with local chronic infection after high-grade glioma treatment: two case reports
JF  - FRONTIERS IN ONCOLOGY
VL  - 12
IS  - December 2022
SP  - 1-7
EP  - 1-7
PB  - FRONTIERS MEDIA SA
SN  - 2234943X
KW  - high-grade glioma
KW  - glioblastoma
KW  - anaplastic astrocytoma
KW  - wound infection
KW  - prolonged survival
UR  - https://www.frontiersin.org/articles/10.3389/fonc.2022.1073036/full
N2  - High-grade gliomas are primary brain tumors with poor prognosis, despite surgical treatment followed by radiotherapy and concomitant chemotherapy. We present two cases of long-term survival in patients treated for high-grade glioma and concomitant prolonged bacterial wound infection. The first patient treated for glioblastoma IDH-wildtype had been without disease progression for 61 months from the first resected recurrence. Despite incomplete chemotherapy-induced myelosuppression in the second patient with anaplastic astrocytoma IDH-mutant, she died without disease relapse after 14 years from the diagnosis due to other comorbidities. We assume that the documented prolonged survival could be related to the bacterial infection.
ER  -

SOLÁR, Peter, Zdeněk MACKERLE, Michal HENDRYCH, Petr POSPÍŠIL, Radek LAKOMÝ, Hana VALEKOVÁ, Markéta HERMANOVÁ and Radim JANČÁLEK. Prolonged survival in patients with local chronic infection after high-grade glioma treatment: two case reports. \textit{FRONTIERS IN ONCOLOGY}. LAUSANNE: FRONTIERS MEDIA SA, 2022, vol.~12, December 2022, p.~1-7. ISSN~2234-943X. Available from: https://dx.doi.org/10.3389/fonc.2022.1073036.

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