| VARGOVÁ, Lenka, Kateřina VYMAZALOVÁ, Ivana JAROŠOVÁ, Ivo MAŘÍK, Ladislava HORÁČKOVÁ, František TRAMPOTA, Katharina REBAY-SALISBURY, Barbara RENDL, Fabian KANZ and Denisa ZLÁMALOVÁ. A case of congenital multiple epiphyseal dysplasia from the Late Migration Period graveyard in Drnholec (Czech Republic). International Journal of Paleopathology. New York: Elsevier, 2023, vol. 40, March 2023, p. 33-40. ISSN 1879-9817. Available from: https://dx.doi.org/10.1016/j.ijpp.2022.11.003. |
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@article{2237978,
author = {Vargová, Lenka and Vymazalová, Kateřina and Jarošová, Ivana and Mařík, Ivo and Horáčková, Ladislava and Trampota, František and RebayandSalisbury, Katharina and Rendl, Barbara and Kanz, Fabian and Zlámalová, Denisa},
article_location = {New York},
article_number = {March 2023},
doi = {http://dx.doi.org/10.1016/j.ijpp.2022.11.003},
keywords = {Congenital defects; Disproporcional growth; Skeletal dysplasia; Tooth cementum annulation (TCA); Langobards},
language = {eng},
issn = {1879-9817},
journal = {International Journal of Paleopathology},
title = {A case of congenital multiple epiphyseal dysplasia from the Late Migration Period graveyard in Drnholec (Czech Republic)},
url = {https://www.sciencedirect.com/science/article/pii/S1879981722000584?via%3Dihub},
volume = {40},
year = {2023}
}
TY - JOUR
ID - 2237978
AU - Vargová, Lenka - Vymazalová, Kateřina - Jarošová, Ivana - Mařík, Ivo - Horáčková, Ladislava - Trampota, František - Rebay-Salisbury, Katharina - Rendl, Barbara - Kanz, Fabian - Zlámalová, Denisa
PY - 2023
TI - A case of congenital multiple epiphyseal dysplasia from the Late Migration Period graveyard in Drnholec (Czech Republic)
JF - International Journal of Paleopathology
VL - 40
IS - March 2023
SP - 33-40
EP - 33-40
PB - Elsevier
SN - 18799817
KW - Congenital defects
KW - Disproporcional growth
KW - Skeletal dysplasia
KW - Tooth cementum annulation (TCA)
KW - Langobards
UR - https://www.sciencedirect.com/science/article/pii/S1879981722000584?via%3Dihub
N2 - Objective To contribute to differential diagnosis of multiple epiphyseal dysplasia (MED) in archeological and clinical contexts. Materials A skeleton of a 30- to 45-year-old male (grave no. 806) from the Late Migration Period graveyard in Drnholec-Pod sýpkou (Czech Republic), radio-carbon dated to AD 492–530. Methods Morphological and metric analyses. Results Significant pathological changes were noted on ossa coxae and proximal ends of the femora, which appear similar to changes associated with Legg-Calvé-Perthes disease. X-ray examination made it possible to rule out pseudoachondroplasia, rickets and metabolic bone diseases. Conclusions The finding was evaluated as a probable case of congenital multiple epiphyseal dysplasia. Significance This case will contribute to the construction of estimates of the occurrence of this disease in historical populations and can be instructive for diagnostics in current medical practice. Limitations The final diagnosis is limited by the lack of genetic analysis. Suggestion for the future research Further clarification leading to diagnosis will benefit from genetic analysis and evaluation of skeletal remains throughout Europe.
ER -
VARGOVÁ, Lenka, Kateřina VYMAZALOVÁ, Ivana JAROŠOVÁ, Ivo MAŘÍK, Ladislava HORÁČKOVÁ, František TRAMPOTA, Katharina REBAY-SALISBURY, Barbara RENDL, Fabian KANZ and Denisa ZLÁMALOVÁ. A case of congenital multiple epiphyseal dysplasia from the Late Migration Period graveyard in Drnholec (Czech Republic). \textit{International Journal of Paleopathology}. New York: Elsevier, 2023, vol.~40, March 2023, p.~33-40. ISSN~1879-9817. Available from: https://dx.doi.org/10.1016/j.ijpp.2022.11.003.
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