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@article{2238150,
author = {Frohlich, Jan and Kovacovicova, Kristina and Raffaele, Marco and Virglova, Tereza and Cizkova, Eliska and Kučera, Jan and Dobrovolná, Julie and Wabitsch, Martin and Peyrou, Marion and Bonomini, Francesca and Rezzani, Rita and Chaldakov, George N. and Tonchev, Anton B. and Di Rosa, Michelino and Blavet, Nicolas and Hejret, Václav and Vinciguerra, Manlio},
article_number = {10},
doi = {http://dx.doi.org/10.1111/cpr.13310},
keywords = {DIFFERENTIATION FACTOR 11; ADIPOSE-TISSUE; SKELETAL-MUSCLE; TGF-BETA; CROSS-TALK; CELL; PROTEIN; WNT; AGE; ADIPONECTIN},
language = {eng},
issn = {0960-7722},
journal = {Cell Proliferation},
title = {GDF11 inhibits adipogenesis and improves mature adipocytes metabolic function via WNT/beta-catenin and ALK5/SMAD2/3 pathways},
url = {https://onlinelibrary.wiley.com/doi/10.1111/cpr.13310},
volume = {55},
year = {2022}
}
TY - JOUR
ID - 2238150
AU - Frohlich, Jan - Kovacovicova, Kristina - Raffaele, Marco - Virglova, Tereza - Cizkova, Eliska - Kučera, Jan - Dobrovolná, Julie - Wabitsch, Martin - Peyrou, Marion - Bonomini, Francesca - Rezzani, Rita - Chaldakov, George N. - Tonchev, Anton B. - Di Rosa, Michelino - Blavet, Nicolas - Hejret, Václav - Vinciguerra, Manlio
PY - 2022
TI - GDF11 inhibits adipogenesis and improves mature adipocytes metabolic function via WNT/beta-catenin and ALK5/SMAD2/3 pathways
JF - Cell Proliferation
VL - 55
IS - 10
SP - 1-15
EP - 1-15
SN - 09607722
KW - DIFFERENTIATION FACTOR 11
KW - ADIPOSE-TISSUE
KW - SKELETAL-MUSCLE
KW - TGF-BETA
KW - CROSS-TALK
KW - CELL
KW - PROTEIN
KW - WNT
KW - AGE
KW - ADIPONECTIN
UR - https://onlinelibrary.wiley.com/doi/10.1111/cpr.13310
N2 - GDF11 is a member of the TGF-beta superfamily that was recently implicated as potential "rejuvenating" factor, which can ameliorate metabolic disorders. The main objective of the presented study was to closely characterize the role of GDF11 signaling in the glucose homeostasis and in the differentiation of white adipose tissue. We performed microscopy imaging, biochemical and transcriptomic analyses of adipose tissues of 9 weeks old ob/ob mice and murine and human preadipocyte cell lines. Our in vivo experiments employing GDF11 treatment in ob/ob mice showed improved glucose/insulin homeostasis, decreased weight gain and white adipocyte size. Furthermore, GDF11 treatment inhibited adipogenesis in pre-adipocytes by ALK5-SMAD2/3 activation in cooperation with the WNT/beta-catenin pathway, whose inhibition resulted in adipogenic differentiation. Lastly, we observed significantly elevated levels of the adipokine hormone adiponectin and increased glucose uptake by mature adipocytes upon GDF11 exposure. We show evidence that link GDF11 to adipogenic differentiation, glucose, and insulin homeostasis, which are pointing towards potential beneficial effects of GDF11-based "anti-obesity" therapy.
ER -
FROHLICH, Jan, Kristina KOVACOVICOVA, Marco RAFFAELE, Tereza VIRGLOVA, Eliska CIZKOVA, Jan KUČERA, Julie DOBROVOLNÁ, Martin WABITSCH, Marion PEYROU, Francesca BONOMINI, Rita REZZANI, George N. CHALDAKOV, Anton B. TONCHEV, Michelino DI ROSA, Nicolas BLAVET, Václav HEJRET and Manlio VINCIGUERRA. GDF11 inhibits adipogenesis and improves mature adipocytes metabolic function via WNT/beta-catenin and ALK5/SMAD2/3 pathways. \textit{Cell Proliferation}. 2022, vol.~55, No~10, p.~1-15. ISSN~0960-7722. Available from: https://dx.doi.org/10.1111/cpr.13310.
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