| SVATON, Martin, Marie DROSSLEROVA, Ondrej FISCHER, Miloslav MAREL, Michal HRNCIARIK, Ondřej VENCLÍČEK, Petr ZUNA, Michal SVOBODA, Jiri BLAZEK, Monika BRATOVÁ, Andrea MULLEROVA, Bohuslava VANKOVA and Daniel KREJCI. Comedication with corticosteroids and nonsteroidal antiphlogistics does not affect PD-L1 expression in non-small cell lung cancer. TRANSLATIONAL CANCER RESEARCH. PEOPLES R CHINA: AME PUBL CO, 2022, vol. 11, No 9, p. 3017-3023. ISSN 2218-676X. Available from: https://dx.doi.org/10.21037/tcr-22-260. |
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@article{2239428,
author = {Svaton, Martin and Drosslerova, Marie and Fischer, Ondrej and Marel, Miloslav and Hrnciarik, Michal and Venclíček, Ondřej and Zuna, Petr and Svoboda, Michal and Blazek, Jiri and Bratová, Monika and Mullerova, Andrea and Vankova, Bohuslava and Krejci, Daniel},
article_location = {PEOPLES R CHINA},
article_number = {9},
doi = {http://dx.doi.org/10.21037/tcr-22-260},
keywords = {Non-small cell lung cancer (NSCLC); lung cancer; programmed death-ligand 1 (PD-L1); non-steroidal anti-inflammatory drugs (NSAIDs); corticosteroids},
language = {eng},
issn = {2218-676X},
journal = {TRANSLATIONAL CANCER RESEARCH},
title = {Comedication with corticosteroids and nonsteroidal antiphlogistics does not affect PD-L1 expression in non-small cell lung cancer},
url = {https://tcr.amegroups.com/article/view/66943/html},
volume = {11},
year = {2022}
}
TY - JOUR
ID - 2239428
AU - Svaton, Martin - Drosslerova, Marie - Fischer, Ondrej - Marel, Miloslav - Hrnciarik, Michal - Venclíček, Ondřej - Zuna, Petr - Svoboda, Michal - Blazek, Jiri - Bratová, Monika - Mullerova, Andrea - Vankova, Bohuslava - Krejci, Daniel
PY - 2022
TI - Comedication with corticosteroids and nonsteroidal antiphlogistics does not affect PD-L1 expression in non-small cell lung cancer
JF - TRANSLATIONAL CANCER RESEARCH
VL - 11
IS - 9
SP - 3017-3023
EP - 3017-3023
PB - AME PUBL CO
SN - 2218676X
KW - Non-small cell lung cancer (NSCLC)
KW - lung cancer
KW - programmed death-ligand 1 (PD-L1)
KW - non-steroidal anti-inflammatory drugs (NSAIDs)
KW - corticosteroids
UR - https://tcr.amegroups.com/article/view/66943/html
N2 - Background: Programmed death-ligand 1 (PD-L1) expression is a standard predictor in the selection of immunotherapy for locally advanced/advanced non-small cell lung cancer (NSCLC). However, comedication with corticosteroids or non-steroidal anti-inflammatory drugs (NSAIDs) may influence the effectiveness of this treatment as documented in several previous studies. Due to certain molecular linkages between PD-L1 and corticosteroids or NSAIDs, we therefore addressed the question of whether there is a relationship between PD-L1 expression in NSCLC and the use of this comedication. Methods: This is a retrospective study using the Czech tumor registry LUng CAncer focuS (LUCAS), from which patient data were drawn. Independence of two categorical parameters was tested by Pearson's chi-square test. Results: In our group of 1,148 patients, we observed no significant relationship between PD-L1 expression and the use of corticosteroids or NSAIDs. Conclusions: According to our data, treatment with corticosteroids or NSAIDs during biopsy does not affect the expression of PD-L1 and it is therefore not necessary to take this treatment into account in this regard.
ER -
SVATON, Martin, Marie DROSSLEROVA, Ondrej FISCHER, Miloslav MAREL, Michal HRNCIARIK, Ondřej VENCLÍČEK, Petr ZUNA, Michal SVOBODA, Jiri BLAZEK, Monika BRATOVÁ, Andrea MULLEROVA, Bohuslava VANKOVA and Daniel KREJCI. Comedication with corticosteroids and nonsteroidal antiphlogistics does not affect PD-L1 expression in non-small cell lung cancer. \textit{TRANSLATIONAL CANCER RESEARCH}. PEOPLES R CHINA: AME PUBL CO, 2022, vol.~11, No~9, p.~3017-3023. ISSN~2218-676X. Available from: https://dx.doi.org/10.21037/tcr-22-260.
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