Comedication with corticosteroids and nonsteroidal
antiphlogistics does not affect PD-L1 expression in non-small
cell lung cancer

J 2022

Comedication with corticosteroids and nonsteroidal antiphlogistics does not affect PD-L1 expression in non-small cell lung cancer

SVATON, Martin, Marie DROSSLEROVA, Ondrej FISCHER, Miloslav MAREL, Michal HRNCIARIK et. al.

Basic information

Original name

Comedication with corticosteroids and nonsteroidal antiphlogistics does not affect PD-L1 expression in non-small cell lung cancer

Authors

SVATON, Martin (203 Czech Republic, guarantor), Marie DROSSLEROVA (203 Czech Republic), Ondrej FISCHER (203 Czech Republic), Miloslav MAREL (203 Czech Republic), Michal HRNCIARIK (203 Czech Republic), Ondřej VENCLÍČEK (203 Czech Republic, belonging to the institution), Petr ZUNA (203 Czech Republic), Michal SVOBODA (203 Czech Republic), Jiri BLAZEK (203 Czech Republic), Monika BRATOVÁ (203 Czech Republic, belonging to the institution), Andrea MULLEROVA (203 Czech Republic), Bohuslava VANKOVA (203 Czech Republic) and Daniel KREJCI (203 Czech Republic)

Edition

TRANSLATIONAL CANCER RESEARCH, PEOPLES R CHINA, AME PUBL CO, 2022, 2218-676X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30203 Respiratory systems

Country of publisher

China

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 0.900

RIV identification code

RIV/00216224:14110/22:00127430

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.21037/tcr-22-260

UT WoS

000835374900001

Keywords in English

Non-small cell lung cancer (NSCLC); lung cancer; programmed death-ligand 1 (PD-L1); non-steroidal anti-inflammatory drugs (NSAIDs); corticosteroids

Abstract

V originále

Background: Programmed death-ligand 1 (PD-L1) expression is a standard predictor in the selection of immunotherapy for locally advanced/advanced non-small cell lung cancer (NSCLC). However, comedication with corticosteroids or non-steroidal anti-inflammatory drugs (NSAIDs) may influence the effectiveness of this treatment as documented in several previous studies. Due to certain molecular linkages between PD-L1 and corticosteroids or NSAIDs, we therefore addressed the question of whether there is a relationship between PD-L1 expression in NSCLC and the use of this comedication. Methods: This is a retrospective study using the Czech tumor registry LUng CAncer focuS (LUCAS), from which patient data were drawn. Independence of two categorical parameters was tested by Pearson's chi-square test. Results: In our group of 1,148 patients, we observed no significant relationship between PD-L1 expression and the use of corticosteroids or NSAIDs. Conclusions: According to our data, treatment with corticosteroids or NSAIDs during biopsy does not affect the expression of PD-L1 and it is therefore not necessary to take this treatment into account in this regard.

Citovat

SVATON, Martin, Marie DROSSLEROVA, Ondrej FISCHER, Miloslav MAREL, Michal HRNCIARIK, Ondřej VENCLÍČEK, Petr ZUNA, Michal SVOBODA, Jiri BLAZEK, Monika BRATOVÁ, Andrea MULLEROVA, Bohuslava VANKOVA and Daniel KREJCI. Comedication with corticosteroids and nonsteroidal antiphlogistics does not affect PD-L1 expression in non-small cell lung cancer. TRANSLATIONAL CANCER RESEARCH. PEOPLES R CHINA: AME PUBL CO, 2022, vol. 11, No 9, p. 3017-3023. ISSN 2218-676X. Available from: https://dx.doi.org/10.21037/tcr-22-260.

@article{2239428,
   author = {Svaton, Martin and Drosslerova, Marie and Fischer, Ondrej and Marel, Miloslav and Hrnciarik, Michal and Venclíček, Ondřej and Zuna, Petr and Svoboda, Michal and Blazek, Jiri and Bratová, Monika and Mullerova, Andrea and Vankova, Bohuslava and Krejci, Daniel},
   article_location = {PEOPLES R CHINA},
   article_number = {9},
   doi = {http://dx.doi.org/10.21037/tcr-22-260},
   keywords = {Non-small cell lung cancer (NSCLC); lung cancer; programmed death-ligand 1 (PD-L1); non-steroidal anti-inflammatory drugs (NSAIDs); corticosteroids},
   language = {eng},
   issn = {2218-676X},
   journal = {TRANSLATIONAL CANCER RESEARCH},
   title = {Comedication with corticosteroids and nonsteroidal antiphlogistics does not affect PD-L1 expression in non-small cell lung cancer},
   url = {https://tcr.amegroups.com/article/view/66943/html},
   volume = {11},
   year = {2022}
}

TY  - JOUR
ID  - 2239428
AU  - Svaton, Martin - Drosslerova, Marie - Fischer, Ondrej - Marel, Miloslav - Hrnciarik, Michal - Venclíček, Ondřej - Zuna, Petr - Svoboda, Michal - Blazek, Jiri - Bratová, Monika - Mullerova, Andrea - Vankova, Bohuslava - Krejci, Daniel
PY  - 2022
TI  - Comedication with corticosteroids and nonsteroidal antiphlogistics does not affect PD-L1 expression in non-small cell lung cancer
JF  - TRANSLATIONAL CANCER RESEARCH
VL  - 11
IS  - 9
SP  - 3017-3023
EP  - 3017-3023
PB  - AME PUBL CO
SN  - 2218676X
KW  - Non-small cell lung cancer (NSCLC)
KW  - lung cancer
KW  - programmed death-ligand 1 (PD-L1)
KW  - non-steroidal anti-inflammatory drugs (NSAIDs)
KW  - corticosteroids
UR  - https://tcr.amegroups.com/article/view/66943/html
N2  - Background: Programmed death-ligand 1 (PD-L1) expression is a standard predictor in the selection of immunotherapy for locally advanced/advanced non-small cell lung cancer (NSCLC). However, comedication with corticosteroids or non-steroidal anti-inflammatory drugs (NSAIDs) may influence the effectiveness of this treatment as documented in several previous studies. Due to certain molecular linkages between PD-L1 and corticosteroids or NSAIDs, we therefore addressed the question of whether there is a relationship between PD-L1 expression in NSCLC and the use of this comedication. Methods: This is a retrospective study using the Czech tumor registry LUng CAncer focuS (LUCAS), from which patient data were drawn. Independence of two categorical parameters was tested by Pearson's chi-square test. Results: In our group of 1,148 patients, we observed no significant relationship between PD-L1 expression and the use of corticosteroids or NSAIDs. Conclusions: According to our data, treatment with corticosteroids or NSAIDs during biopsy does not affect the expression of PD-L1 and it is therefore not necessary to take this treatment into account in this regard.
ER  -

SVATON, Martin, Marie DROSSLEROVA, Ondrej FISCHER, Miloslav MAREL, Michal HRNCIARIK, Ondřej VENCLÍČEK, Petr ZUNA, Michal SVOBODA, Jiri BLAZEK, Monika BRATOVÁ, Andrea MULLEROVA, Bohuslava VANKOVA and Daniel KREJCI. Comedication with corticosteroids and nonsteroidal antiphlogistics does not affect PD-L1 expression in non-small cell lung cancer. \textit{TRANSLATIONAL CANCER RESEARCH}. PEOPLES R CHINA: AME PUBL CO, 2022, vol.~11, No~9, p.~3017-3023. ISSN~2218-676X. Available from: https://dx.doi.org/10.21037/tcr-22-260.

Detailed Information on Publication Record