Genetic mechanism for the loss of PRAME in B cell lymphomas

J 2022

Genetic mechanism for the loss of PRAME in B cell lymphomas

MRÁZ, Marek

Basic information

Original name

Genetic mechanism for the loss of PRAME in B cell lymphomas

Authors

MRÁZ, Marek (203 Czech Republic, guarantor, belonging to the institution)

Edition

Journal of Clinical Investigation, Ann Arbor, AMER SOC CLINICAL INVESTIGATION INC, 2022, 0021-9738

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30205 Hematology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 15.900

RIV identification code

RIV/00216224:14740/22:00127432

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1172/JCI160983

UT WoS

000844140900002

Keywords in English

CHRONIC LYMPHOCYTIC-LEUKEMIA22Q11

Abstract

V originále

To the Editor: Takata et al. (1) reported that patients with diffuse large B cell lymphoma (DLBCL) relatively frequently (13% of patients) harbor a deletion at the 22q11.22 locus that involves the PRAME gene, and that PRAME loss is associated with poor outcomes and leads to cytotoxic T cell immune escape. The authors comment that “deletions...were located close to the Igλ gene.” I would like to bring to the attention of the authors and readers that the PRAME gene and neighboring ZNF280A, ZNF280B, and GGTLC2 genes are located between variable (V) subgenes for the immunoglobulin lambda (Igλ) light chain (Figure 1). The PRAME deletion is inevitable when a B lymphocyte (normal or malignant) rearranges the Igλ locus and utilizes one of the many V subgenes located more distantly from the J-C region. It is known that approximately 30% to 40% of B lymphocytes express Igλ (~60%–70% express Igκ, since this locus for the Ig light chain is rearranged before Igλ). Therefore, it is not surprising that the loss of PRAME has been previously noted in multiple B cell malignancies, especially chronic lymphocytic leukemia (2–4). Takata et al. (1) observed that patients with PRAME deletions more often have an Igλ rearrangement, but they also report cases of DLBCL with a PRAME deletion and rearranged Igκ.

Citovat

MRÁZ, Marek. Genetic mechanism for the loss of PRAME in B cell lymphomas. Journal of Clinical Investigation. Ann Arbor: AMER SOC CLINICAL INVESTIGATION INC, 2022, vol. 132, No 14, p. nestrankovano, 1 pp. ISSN 0021-9738. Available from: https://dx.doi.org/10.1172/JCI160983.

@article{2239435,
   author = {Mráz, Marek},
   article_location = {Ann Arbor},
   article_number = {14},
   doi = {http://dx.doi.org/10.1172/JCI160983},
   keywords = {CHRONIC LYMPHOCYTIC-LEUKEMIA22Q11},
   language = {eng},
   issn = {0021-9738},
   journal = {Journal of Clinical Investigation},
   title = {Genetic mechanism for the loss of PRAME in B cell lymphomas},
   url = {https://www.jci.org/articles/view/160983},
   volume = {132},
   year = {2022}
}

TY  - JOUR
ID  - 2239435
AU  - Mráz, Marek
PY  - 2022
TI  - Genetic mechanism for the loss of PRAME in B cell lymphomas
JF  - Journal of Clinical Investigation
VL  - 132
IS  - 14
SP  - nestrankovano
EP  - nestrankovano
PB  - AMER SOC CLINICAL INVESTIGATION INC
SN  - 00219738
KW  - CHRONIC LYMPHOCYTIC-LEUKEMIA22Q11
UR  - https://www.jci.org/articles/view/160983
N2  - To the Editor: Takata et al. (1) reported that patients with diffuse large B cell lymphoma (DLBCL) relatively frequently (13% of patients) harbor a deletion at the 22q11.22 locus that involves the PRAME gene, and that PRAME loss is associated with poor outcomes and leads to cytotoxic T cell immune escape. The authors comment that “deletions...were located close to the Igλ gene.” I would like to bring to the attention of the authors and readers that the PRAME gene and neighboring ZNF280A, ZNF280B, and GGTLC2 genes are located between variable (V) subgenes for the immunoglobulin lambda (Igλ) light chain (Figure 1). The PRAME deletion is inevitable when a B lymphocyte (normal or malignant) rearranges the Igλ locus and utilizes one of the many V subgenes located more distantly from the J-C region. It is known that approximately 30% to 40% of B lymphocytes express Igλ (~60%–70% express Igκ, since this locus for the Ig light chain is rearranged before Igλ). Therefore, it is not surprising that the loss of PRAME has been previously noted in multiple B cell malignancies, especially chronic lymphocytic leukemia (2–4). Takata et al. (1) observed that patients with PRAME deletions more often have an Igλ rearrangement, but they also report cases of DLBCL with a PRAME deletion and rearranged Igκ.
ER  -

MRÁZ, Marek. Genetic mechanism for the loss of PRAME in B cell lymphomas. \textit{Journal of Clinical Investigation}. Ann Arbor: AMER SOC CLINICAL INVESTIGATION INC, 2022, vol.~132, No~14, p.~nestrankovano, 1 pp. ISSN~0021-9738. Available from: https://dx.doi.org/10.1172/JCI160983.

Detailed Information on Publication Record