Detailed Information on Publication Record
2022
Multimodal combination of neuroimaging methods for localizing the epileptogenic zone in MR-negative epilepsy
ŘÍHA, Pavel, Irena DOLEŽALOVÁ, Radek MAREČEK, Martin LAMOŠ, Michaela BARTOŇOVÁ et. al.Basic information
Original name
Multimodal combination of neuroimaging methods for localizing the epileptogenic zone in MR-negative epilepsy
Authors
ŘÍHA, Pavel (203 Czech Republic, belonging to the institution), Irena DOLEŽALOVÁ (203 Czech Republic, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution), Martin LAMOŠ (203 Czech Republic, belonging to the institution), Michaela BARTOŇOVÁ (703 Slovakia, belonging to the institution), Martin KOJAN (703 Slovakia, belonging to the institution), Michal MIKL (203 Czech Republic, belonging to the institution), Martin GAJDOŠ (203 Czech Republic, belonging to the institution), Lubomír VOJTÍŠEK (203 Czech Republic, belonging to the institution), Marek BARTOŇ (203 Czech Republic, belonging to the institution), Ondřej STRÝČEK (203 Czech Republic, belonging to the institution), Martin PAIL (203 Czech Republic, belonging to the institution), Milan BRÁZDIL (203 Czech Republic, belonging to the institution) and Ivan REKTOR (203 Czech Republic, guarantor, belonging to the institution)
Edition
Nature Scientific Reports, London, NATURE RESEARCH, 2022, 2045-2322
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30103 Neurosciences
Country of publisher
Germany
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 4.600
RIV identification code
RIV/00216224:14740/22:00127439
Organization unit
Central European Institute of Technology
UT WoS
000852630800033
Keywords in English
FOCAL CORTICAL DYSPLASIATEMPORAL-LOBE EPILEPSYREGIONAL HOMOGENEITYIMPROVES DETECTIONABNORMALITIESCHILDRENFEATURESSURGERYEEG
Tags
International impact, Reviewed
Změněno: 10/10/2024 10:37, Ing. Jana Kuchtová
Abstract
V originále
The objective was to determine the optimal combination of multimodal imaging methods (IMs) for localizing the epileptogenic zone (EZ) in patients with MR-negative drug-resistant epilepsy. Data from 25 patients with MR-negative focal epilepsy (age 30 +/- 10 years, 16M/9F) who underwent surgical resection of the EZ and from 110 healthy controls (age 31 +/- 9 years; 56M/54F) were used to evaluate IMs based on 3T MRI, FDG-PET, HD-EEG, and SPECT. Patients with successful outcomes and/or positive histological findings were evaluated. From 38 IMs calculated per patient, 13 methods were selected by evaluating the mutual similarity of the methods and the accuracy of the EZ localization. The best results in postsurgical patients for EZ localization were found for ictal/ interictal SPECT (SISCOM), FDG-PET, arterial spin labeling (ASL), functional regional homogeneity (ReHo), gray matter volume (GMV), cortical thickness, HD electrical source imaging (ESI-HD), amplitude of low-frequency fluctuation (ALFF), diffusion tensor imaging, and kurtosis imaging. Combining IMs provides the method with the most accurate EZ identification in MR-negative epilepsy. The PET, SISCOM, and selected MRI-post-processing techniques are useful for EZ localization for surgical tailoring.
Links
NU21-04-00254, research and development project |
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90129, large research infrastructures |
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