Detailed Information on Publication Record
2022
Differential spatial distribution of white matter lesions in Parkinson's and Alzheimer's diseases and cognitive sequelae
GREY, Michael Teodor, Kristína MITTEROVÁ, Martin GAJDOŠ, Richard UHER, Patrícia KLOBUŠIAKOVÁ et. al.Basic information
Original name
Differential spatial distribution of white matter lesions in Parkinson's and Alzheimer's diseases and cognitive sequelae
Authors
GREY, Michael Teodor (703 Slovakia, belonging to the institution), Kristína MITTEROVÁ (703 Slovakia, belonging to the institution), Martin GAJDOŠ (203 Czech Republic, belonging to the institution), Richard UHER (203 Czech Republic, belonging to the institution), Patrícia KLOBUŠIAKOVÁ (703 Slovakia, belonging to the institution), Irena REKTOROVÁ (203 Czech Republic, belonging to the institution) and Ivan REKTOR (203 Czech Republic, guarantor, belonging to the institution)
Edition
Journal of Neural Transmission, WIEN, SPRINGER WIEN, 2022, 0300-9564
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30103 Neurosciences
Country of publisher
Austria
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 3.300
RIV identification code
RIV/00216224:14740/22:00127441
Organization unit
Central European Institute of Technology
UT WoS
000823317800001
Keywords in English
White matter lesions; WML; Parkinson's disease; PD; Alzheimer's disease; AD; MCI; Cognitive decline; Subcortical; Periventricular; Cognitive domain
Tags
International impact, Reviewed
Změněno: 10/10/2024 09:51, Ing. Jana Kuchtová
Abstract
V originále
White Matter Lesions (WML) are a radiological finding common in aged subjects. We explored the impact of WML on underlying neurodegenerative processes. We focused on the impact of WML on two neurodegenerative diseases with different pathology. In this cross-sectional study of 137 subjects (78 female, 59 men, mean age 67.2; 43–87 years), we compared WML in healthy controls (HC; n = 55), patients with Alzheimer’s disease and amnestic Mild Cognitive Impairment (aMCI), and Parkinson’s disease patients with normal cognition and with MCI. Subjects with AD and aMCI were treated as one group (n = 40), subjects with PD and PDMCI were another group (n = 42). MRI T2_FLAIR sequences were analyzed. WML were divided into periventricular (pWML) or subcortical (sWML) depending on their distance from the ventricles. Subjects from the AD + aMCI group, had a significantly greater volume of WML than both HC and the PD + PDMCI group. The volume of WML was greater in the PD + PDMCI than in HC but the difference was not significant. In AD + aMCI subjects, sWML and not pWML were related to a decrease in global cognitive functioning despite greater volume of pWML. In PD + PDMCI, pWML correlate with decline in executive functions and working memory. In HC, pWML correlated with the multidomain decrease corresponding with the aging. This points to a difference between normal aging and pathological aging due to AD and PD brain pathology. The WML location together with underlying disease related neurodegeneration may play a role in determining the effect of WML on cognition. Our results suggest that the impact of WML is not uniform in all patients; rather, their volume, location and cognitive effect may be disease-specific.
Links
| GA21-25953S, research and development project |
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| NU20-04-00294, research and development project |
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| NU21-04-00445, research and development project |
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| 90129, large research infrastructures |
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