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@article{2239501,
author = {Grey, Michael Teodor and Mitterová, Kristína and Gajdoš, Martin and Uher, Richard and Klobušiaková, Patrícia and Rektorová, Irena and Rektor, Ivan},
article_location = {WIEN},
article_number = {8},
doi = {http://dx.doi.org/10.1007/s00702-022-02519-z},
keywords = {White matter lesions; WML; Parkinson's disease; PD; Alzheimer's disease; AD; MCI; Cognitive decline; Subcortical; Periventricular; Cognitive domain},
language = {eng},
issn = {0300-9564},
journal = {Journal of Neural Transmission},
title = {Differential spatial distribution of white matter lesions in Parkinson's and Alzheimer's diseases and cognitive sequelae},
url = {https://link.springer.com/article/10.1007/s00702-022-02519-z},
volume = {129},
year = {2022}
}
TY - JOUR
ID - 2239501
AU - Grey, Michael Teodor - Mitterová, Kristína - Gajdoš, Martin - Uher, Richard - Klobušiaková, Patrícia - Rektorová, Irena - Rektor, Ivan
PY - 2022
TI - Differential spatial distribution of white matter lesions in Parkinson's and Alzheimer's diseases and cognitive sequelae
JF - Journal of Neural Transmission
VL - 129
IS - 8
SP - 1023-1030
EP - 1023-1030
PB - SPRINGER WIEN
SN - 03009564
KW - White matter lesions
KW - WML
KW - Parkinson's disease
KW - PD
KW - Alzheimer's disease
KW - AD
KW - MCI
KW - Cognitive decline
KW - Subcortical
KW - Periventricular
KW - Cognitive domain
UR - https://link.springer.com/article/10.1007/s00702-022-02519-z
N2 - White Matter Lesions (WML) are a radiological finding common in aged subjects. We explored the impact of WML on underlying neurodegenerative processes. We focused on the impact of WML on two neurodegenerative diseases with different pathology. In this cross-sectional study of 137 subjects (78 female, 59 men, mean age 67.2; 43–87 years), we compared WML in healthy controls (HC; n = 55), patients with Alzheimer’s disease and amnestic Mild Cognitive Impairment (aMCI), and Parkinson’s disease patients with normal cognition and with MCI. Subjects with AD and aMCI were treated as one group (n = 40), subjects with PD and PDMCI were another group (n = 42). MRI T2_FLAIR sequences were analyzed. WML were divided into periventricular (pWML) or subcortical (sWML) depending on their distance from the ventricles. Subjects from the AD + aMCI group, had a significantly greater volume of WML than both HC and the PD + PDMCI group. The volume of WML was greater in the PD + PDMCI than in HC but the difference was not significant. In AD + aMCI subjects, sWML and not pWML were related to a decrease in global cognitive functioning despite greater volume of pWML. In PD + PDMCI, pWML correlate with decline in executive functions and working memory. In HC, pWML correlated with the multidomain decrease corresponding with the aging. This points to a difference between normal aging and pathological aging due to AD and PD brain pathology. The WML location together with underlying disease related neurodegeneration may play a role in determining the effect of WML on cognition. Our results suggest that the impact of WML is not uniform in all patients; rather, their volume, location and cognitive effect may be disease-specific.
ER -
GREY, Michael Teodor, Kristína MITTEROVÁ, Martin GAJDOŠ, Richard UHER, Patrícia KLOBUŠIAKOVÁ, Irena REKTOROVÁ and Ivan REKTOR. Differential spatial distribution of white matter lesions in Parkinson's and Alzheimer's diseases and cognitive sequelae. \textit{Journal of Neural Transmission}. WIEN: SPRINGER WIEN, 2022, vol.~129, No~8, p.~1023-1030. ISSN~0300-9564. Available from: https://dx.doi.org/10.1007/s00702-022-02519-z.
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