CompuSyn Report
Experiment Name:kombinace straých a nových dat
Date: 210716
File Name:C:\Users\B\Documents\ABT-737\07_2021_compusyn\LA H HT29.cse
Descriptionkombinace straých a nových dat
HT29
mikroprostředí

Drug:LA HYPO perifosine (perif) [uM]
Drug:LA HYPO abt737 (ABT737) [uM]
Drug Combo:LA HYPO (LAH) (perif+ABT737)

Data for Drug: perif [uM]
DoseEffect
5.0     0.0893
10.0     0.126
20.0     0.3402
40.0     0.6975
4 data points entered.
X-int:1.43663
Y-int:-2.2275 +/- 0.31488
m:1.55051 +/- 0.26268
Dm:27.3297
r:0.97248
Data for Drug: ABT737 [uM]
DoseEffect
5.0     0.5664
10.0     0.6869
20.0     0.809
40.0     0.8295
4 data points entered.
X-int:0.48364
Y-int:-0.3211 +/- 0.13146
m:0.66401 +/- 0.10966
Dm:3.04538
r:0.97379
Data for Non-Constant Combo: LAH (perif+ABT737)
Dose perifDose ABT737Effect
5.0     5.0     0.727
10.0     5.0     0.7951
20.0     5.0     0.859
40.0     5.0     0.9098
5.0     10.0     0.8311
10.0     10.0     0.8426
20.0     10.0     0.8951
40.0     10.0     0.8779
5.0     20.0     0.8672
10.0     20.0     0.8803
20.0     20.0     0.9074
40.0     20.0     0.9279
5.0     40.0     0.8951
10.0     40.0     0.9082
20.0     40.0     0.918
40.0     40.0     0.9361
16 data points entered.
Dose-Effect Curve
Median-Effect Plot
CI Data for Non-Constant Combo: LAH (perif+ABT737)
Dose perifDose ABT737EffectCI
5.0     5.0     0.727     0.47287
10.0     5.0     0.7951     0.36565
20.0     5.0     0.859     0.33618
40.0     5.0     0.9098     0.38021
5.0     10.0     0.8311     0.36344
10.0     10.0     0.8426     0.38647
20.0     10.0     0.8951     0.31366
40.0     10.0     0.8779     0.57841
5.0     20.0     0.8672     0.44370
10.0     20.0     0.8803     0.42642
20.0     20.0     0.9074     0.37912
40.0     20.0     0.9279     0.42180
5.0     40.0     0.8951     0.56613
10.0     40.0     0.9082     0.49979
20.0     40.0     0.918     0.49972
40.0     40.0     0.9361     0.48965
Combination Index Plot
DRI Data for Non-Constant Combo: LAH (perif+ABT737)
FaDose perifDose ABT737DRI perifDRI ABT737
0.727     51.4018     13.3122     10.2804     2.66243     
0.7951     65.5289     23.4688     6.55289     4.69376     
0.859     87.6547     46.2921     4.38274     9.25841     
0.9098     121.338     98.9161     3.03345     19.7832     
0.8311     76.3758     33.5602     15.2752     3.35602     
0.8426     80.6411     38.1008     8.06411     3.81008     
0.8951     108.930     76.8894     5.44648     7.68894     
0.8779     97.5400     59.4115     2.43850     5.94115     
0.8672     91.6682     51.3935     18.3336     2.56967     
0.8803     98.9710     61.4668     9.89710     3.07334     
0.9074     119.097     94.7031     5.95486     4.73516     
0.9279     141.987     142.771     3.54969     7.13857     
0.8951     108.930     76.8894     21.7859     1.92224     
0.9082     119.834     96.0762     11.9834     2.40191     
0.918     129.780     115.737     6.48898     2.89343     
0.9361     154.359     173.525     3.85897     4.33812     
DRI Plot for Non-Constant Combo: LAH (perif+ABT737)
Normalized Isobologram for Combo: LAH (perif+ABT737)
Summary Table
Experiment Name:kombinace straých a nových dat
Date: 210716
File Name:C:\Users\B\Documents\ABT-737\07_2021_compusyn\LA H HT29.cse
Descriptionkombinace straých a nových dat
HT29
mikroprostředí

Drug:LA HYPO perifosine (perif) [uM]
Drug:LA HYPO abt737 (ABT737) [uM]
Drug Combo:LA HYPO (LAH) (perif+ABT737)

Drug/ComboDmmr
perif27.3297     1.55051     0.97248
ABT7373.04538     0.66401     0.97379
CI values at:
ComboED50ED75ED90ED95
Data for Fa = 0.5
Drug/Combo CI valueDose perifDose ABT737
perif27.3297
ABT7373.04538
Data for Fa = 0.75
Drug/Combo CI valueDose perifDose ABT737
perif55.5079
ABT73715.9288
Data for Fa = 0.9
Drug/Combo CI valueDose perifDose ABT737
perif112.739
ABT73783.3154
Data for Fa = 0.95
Drug/Combo CI valueDose perifDose ABT737
perif182.544
ABT737256.707
Data for Fa = 0.97
Drug/Combo CI valueDose perifDose ABT737
perif257.208
ABT737571.697