CompuSyn Report
Experiment Name:LA NORMO HT29
Date: 210716
File Name:C:\Users\B\Documents\ABT-737\07_2021_compusyn\LA N HT29.cse
Descriptionkombinace straých a nových dat

Drug:PERIFOSINE (perif) [uM]
Drug:abt-737 (ABT737) [uM]
Drug Combo:perifosine+abt LA N (LA N) (perif+ABT737)

Data for Drug: perif [uM]
DoseEffect
10.0     0.0335
20.0     0.2675
40.0     0.5323
3 data points entered.
X-int:1.54474
Y-int:-3.8906 +/- 0.67167
m:2.51860 +/- 0.50729
Dm:35.0545
r:0.98031
Data for Drug: ABT737 [uM]
DoseEffect
5.0     0.0425
10.0     0.2852
20.0     0.4618
40.0     0.7952
4 data points entered.
X-int:1.30072
Y-int:-2.6609 +/- 0.32545
m:2.04572 +/- 0.27149
Dm:19.9858
r:0.98284
Data for Non-Constant Combo: LA N (perif+ABT737)
Dose perifDose ABT737Effect
5.0     5.0     0.2487
10.0     5.0     0.1907
20.0     5.0     0.4743
40.0     5.0     0.8216
5.0     10.0     0.4328
10.0     10.0     0.5332
20.0     10.0     0.693
40.0     10.0     0.9063
5.0     20.0     0.6986
10.0     20.0     0.7877
20.0     20.0     0.8815
40.0     20.0     0.95
5.0     40.0     0.9054
10.0     40.0     0.945
20.0     40.0     0.976
40.0     40.0     0.981
16 data points entered.
Dose-Effect Curve
Median-Effect Plot
CI Data for Non-Constant Combo: LA N (perif+ABT737)
Dose perifDose ABT737EffectCI
5.0     5.0     0.2487     0.65073
10.0     5.0     0.1907     1.01354
20.0     5.0     0.4743     0.85741
40.0     5.0     0.8216     0.74084
5.0     10.0     0.4328     0.72987
10.0     10.0     0.5332     0.73946
20.0     10.0     0.693     0.74902
40.0     10.0     0.9063     0.62848
5.0     20.0     0.6986     0.76566
10.0     20.0     0.7877     0.69669
20.0     20.0     0.8815     0.63242
40.0     20.0     0.95     0.59174
5.0     40.0     0.9054     0.72165
10.0     40.0     0.945     0.59066
20.0     40.0     0.976     0.45814
40.0     40.0     0.981     0.52943
Combination Index Plot
DRI Data for Non-Constant Combo: LA N (perif+ABT737)
FaDose perifDose ABT737DRI perifDRI ABT737
0.2487     22.5999     11.6418     4.51999     2.32835     
0.1907     19.7467     9.85957     1.97467     1.97191     
0.4743     33.6513     19.0055     1.68257     3.80110     
0.8216     64.2823     42.1641     1.60706     8.43283     
0.4328     31.4856     17.5110     6.29711     1.75110     
0.5332     36.9553     21.3283     3.69553     2.13283     
0.693     48.4326     29.7556     2.42163     2.97556     
0.9063     86.3070     60.6004     2.15768     6.06004     
0.6986     48.9440     30.1429     9.78881     1.50715     
0.7877     58.9966     37.9371     5.89966     1.89686     
0.8815     77.7628     53.3010     3.88814     2.66505     
0.95     112.841     84.2964     2.82104     4.21482     
0.9054     85.9462     60.2886     17.1892     1.50721     
0.945     108.424     80.2519     10.8424     2.00630     
0.976     152.646     122.281     7.63232     3.05702     
0.981     167.823     137.416     4.19557     3.43541     
DRI Plot for Non-Constant Combo: LA N (perif+ABT737)
Normalized Isobologram for Combo: LA N (perif+ABT737)
Summary Table
Experiment Name:LA NORMO HT29
Date: 210716
File Name:C:\Users\B\Documents\ABT-737\07_2021_compusyn\LA N HT29.cse
Descriptionkombinace straých a nových dat

Drug:PERIFOSINE (perif) [uM]
Drug:abt-737 (ABT737) [uM]
Drug Combo:perifosine+abt LA N (LA N) (perif+ABT737)

Drug/ComboDmmr
perif35.0545     2.51860     0.98031
ABT73719.9858     2.04572     0.98284
CI values at:
ComboED50ED75ED90ED95
Data for Fa = 0.5
Drug/Combo CI valueDose perifDose ABT737
perif35.0545
ABT73719.9858
Data for Fa = 0.75
Drug/Combo CI valueDose perifDose ABT737
perif54.2230
ABT73734.1941
Data for Fa = 0.9
Drug/Combo CI valueDose perifDose ABT737
perif83.8731
ABT73758.5032
Data for Fa = 0.95
Drug/Combo CI valueDose perifDose ABT737
perif112.841
ABT73784.2964
Data for Fa = 0.97
Drug/Combo CI valueDose perifDose ABT737
perif139.362
ABT737109.314