CompuSyn Report
Experiment Name:kombinace straých a nových dat
Date: 210716
File Name:C:\Users\B\Documents\ABT-737\REVIZE\nal hypo 221108.cse
Descriptionkombinace straých a nových dat
HT29
mikroprostředí

Drug:NaL HYPO perifosine (perif) [uM]
Drug:NaL HYPO abt737 (ABT737) [uM]
Drug Combo:NaL HYPO (NaLH) (perif+ABT737)

Data for Drug: perif [uM]
DoseEffect
5.0     0.4219
10.0     0.6423
20.0     0.7432
40.0     0.8407
4 data points entered.
X-int:0.79885
Y-int:-0.7390 +/- 0.10572
m:0.92514 +/- 0.08819
Dm:6.29287
r:0.99103
Data for Drug: ABT737 [uM]
DoseEffect
5.0     0.4794
10.0     0.5286
20.0     0.5275
3 data points entered.
X-int:0.85181
Y-int:-0.1183 +/- 0.08637
m:0.13890 +/- 0.08387
Dm:7.10899
r:0.85605
Data for Non-Constant Combo: NaLH (perif+ABT737)
Dose perifDose ABT737Effect
5.0     5.0     0.709
10.0     5.0     0.8125
20.0     5.0     0.9
40.0     5.0     0.9297
5.0     10.0     0.7151
10.0     10.0     0.8033
20.0     10.0     0.902
40.0     10.0     0.9443
5.0     20.0     0.7413
10.0     20.0     0.8322
20.0     20.0     0.9224
40.0     20.0     0.955
5.0     40.0     0.8466
10.0     40.0     0.9155
20.0     40.0     0.9742
40.0     40.0     0.9804
16 data points entered.
Dose-Effect Curve
Median-Effect Plot
CI Data for Non-Constant Combo: NaLH (perif+ABT737)
Dose perifDose ABT737EffectCI
5.0     5.0     0.709     0.30460
10.0     5.0     0.8125     0.32570
20.0     5.0     0.9     0.29561
40.0     5.0     0.9297     0.39002
5.0     10.0     0.7151     0.29570
10.0     10.0     0.8033     0.34730
20.0     10.0     0.902     0.28853
40.0     10.0     0.9443     0.29819
5.0     20.0     0.7413     0.25608
10.0     20.0     0.8322     0.28150
20.0     20.0     0.9224     0.21884
40.0     20.0     0.955     0.23392
5.0     40.0     0.8466     0.12541
10.0     40.0     0.9155     0.12095
20.0     40.0     0.9742     0.06274
40.0     40.0     0.9804     0.09259
Combination Index Plot
DRI Data for Non-Constant Combo: NaLH (perif+ABT737)
FaDose perifDose ABT737DRI perifDRI ABT737
0.709     16.4777     4327.00     3.29555     865.400     
0.8125     30.7044     273228.     3.07044     54645.5     
0.9     67.6560     5.269E7     3.38280     1.054E7     
0.9297     102.560     8.416E8     2.56399     1.683E8     
0.7151     17.0163     5360.56     3.40325     536.056     
0.8033     28.7984     178300.     2.87984     17830.0     
0.902     69.3158     6.192E7     3.46579     6192385     
0.9443     134.144     5.031E9     3.35361     5.031E8     
0.7413     19.6355     13910.5     3.92710     695.523     
0.8322     35.5269     721948.     3.55269     36097.4     
0.9224     91.3898     3.904E8     4.56949     1.952E7     
0.955     171.002     2.53E10     4.27505     1.267E9     
0.8466     39.8778     1558404     7.97555     38960.1     
0.9155     82.6769     2.003E8     8.26769     5008016     
0.9742     318.777     1.60E12     15.9389     4.01E10     
0.9804     432.004     1.22E13     10.8001     3.04E11     
DRI Plot for Non-Constant Combo: NaLH (perif+ABT737)
Normalized Isobologram for Combo: NaLH (perif+ABT737)
Summary Table
Experiment Name:kombinace straých a nových dat
Date: 210716
File Name:C:\Users\B\Documents\ABT-737\REVIZE\nal hypo 221108.cse
Descriptionkombinace straých a nových dat
HT29
mikroprostředí

Drug:NaL HYPO perifosine (perif) [uM]
Drug:NaL HYPO abt737 (ABT737) [uM]
Drug Combo:NaL HYPO (NaLH) (perif+ABT737)

Drug/ComboDmmr
perif6.29287     0.92514     0.99103
ABT7377.10899     0.13890     0.85605
CI values at:
ComboED50ED75ED90ED95
Data for Fa = 0.5
Drug/Combo CI valueDose perifDose ABT737
perif6.29287
ABT7377.10899
Data for Fa = 0.75
Drug/Combo CI valueDose perifDose ABT737
perif20.6337
ABT73719354.4
Data for Fa = 0.9
Drug/Combo CI valueDose perifDose ABT737
perif67.6560
ABT7375.269E7
Data for Fa = 0.95
Drug/Combo CI valueDose perifDose ABT737
perif151.732
ABT7371.14E10
Data for Fa = 0.97
Drug/Combo CI valueDose perifDose ABT737
perif269.561
ABT7375.25E11