How Effective Are Non-Operative Intra-Articular Treatments for
Bone Marrow Lesions in Knee Osteoarthritis in Adults? A
Systematic Review of Controlled Clinical Trials

J 2022

How Effective Are Non-Operative Intra-Articular Treatments for Bone Marrow Lesions in Knee Osteoarthritis in Adults? A Systematic Review of Controlled Clinical Trials

KLEINSCHMIDT, A. C., A. SINGH, Mohammad Salman HUSSAIN, G. A. LOVELL, A. W. SHEE et. al.

Basic information

Original name

How Effective Are Non-Operative Intra-Articular Treatments for Bone Marrow Lesions in Knee Osteoarthritis in Adults? A Systematic Review of Controlled Clinical Trials

Authors

KLEINSCHMIDT, A. C., A. SINGH (guarantor), Mohammad Salman HUSSAIN (356 India, belonging to the institution), G. A. LOVELL and A. W. SHEE

Edition

Pharmaceuticals, Basel, MDPI, 2022, 1424-8247

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.600

RIV identification code

RIV/00216224:14110/22:00127500

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3390/ph15121555

UT WoS

000904567100001

Keywords in English

knee osteoarthritis; sprifermin; autologous protein solution; systematic review

Abstract

V originále

Knee osteoarthritis (KOA) is a progressive joint disease and a leading source of chronic pain and disability. OA-bone marrow lesions (BMLs) are a recognised aetiopathological feature of KOA. Several intra-articular injectable therapies are recommended and used for management of KOA. This systematic review assessed the efficacy and safety of intra-articular therapies for improving OA-BMLs and reducing pain in adults with KOA. The study was conducted following registered review protocol (PROSPERO CRD42020189461) and six bibliographic databases, and two clinical trial registries were searched. We included eight randomised clinical trials involving 1294 participants, reported in 12 publications from 2016 to 2021. Two studies of sprifermin, one of autologous protein solution (APS) and one of high-dose TissueGene-C, reported a positive effect on OA-BMLs under 1-year follow-up. Two studies with corticosteroids reported mixed findings with no beneficial effect beyond 14 weeks of follow-up. One study assessing platelet-rich plasma found no significant improvement in OA-BMLs at 12 months follow-up. Knee pain was improved in two studies evaluating TissueGene-C and one study assessing APS; the remaining studies found no improvement in knee pain. Overall, we found mixed evidence on the efficacy of intra-articular therapy for improving OA-BMLs in KOA. Additional studies with long-term follow-up are needed to confirm the effect of various intra-articular therapies on OA-BMLs in KOA.

Links

EF18_053/0016952, research and development project

Name: Postdoc2MUNI

Citovat

KLEINSCHMIDT, A. C., A. SINGH, Mohammad Salman HUSSAIN, G. A. LOVELL and A. W. SHEE. How Effective Are Non-Operative Intra-Articular Treatments for Bone Marrow Lesions in Knee Osteoarthritis in Adults? A Systematic Review of Controlled Clinical Trials. Pharmaceuticals. Basel: MDPI, 2022, vol. 15, No 12, p. 1-17. ISSN 1424-8247. Available from: https://dx.doi.org/10.3390/ph15121555.

@article{2240840,
   author = {Kleinschmidt, A. C. and Singh, A. and Hussain, Mohammad Salman and Lovell, G. A. and Shee, A. W.},
   article_location = {Basel},
   article_number = {12},
   doi = {http://dx.doi.org/10.3390/ph15121555},
   keywords = {knee osteoarthritis; sprifermin; autologous protein solution; systematic review},
   language = {eng},
   issn = {1424-8247},
   journal = {Pharmaceuticals},
   title = {How Effective Are Non-Operative Intra-Articular Treatments for Bone Marrow Lesions in Knee Osteoarthritis in Adults? A Systematic Review of Controlled Clinical Trials},
   url = {https://www.mdpi.com/1424-8247/15/12/1555},
   volume = {15},
   year = {2022}
}

TY  - JOUR
ID  - 2240840
AU  - Kleinschmidt, A. C. - Singh, A. - Hussain, Mohammad Salman - Lovell, G. A. - Shee, A. W.
PY  - 2022
TI  - How Effective Are Non-Operative Intra-Articular Treatments for Bone Marrow Lesions in Knee Osteoarthritis in Adults? A Systematic Review of Controlled Clinical Trials
JF  - Pharmaceuticals
VL  - 15
IS  - 12
SP  - 1-17
EP  - 1-17
PB  - MDPI
SN  - 14248247
KW  - knee osteoarthritis
KW  - sprifermin
KW  - autologous protein solution
KW  - systematic review
UR  - https://www.mdpi.com/1424-8247/15/12/1555
N2  - Knee osteoarthritis (KOA) is a progressive joint disease and a leading source of chronic pain and disability. OA-bone marrow lesions (BMLs) are a recognised aetiopathological feature of KOA. Several intra-articular injectable therapies are recommended and used for management of KOA. This systematic review assessed the efficacy and safety of intra-articular therapies for improving OA-BMLs and reducing pain in adults with KOA. The study was conducted following registered review protocol (PROSPERO CRD42020189461) and six bibliographic databases, and two clinical trial registries were searched. We included eight randomised clinical trials involving 1294 participants, reported in 12 publications from 2016 to 2021. Two studies of sprifermin, one of autologous protein solution (APS) and one of high-dose TissueGene-C, reported a positive effect on OA-BMLs under 1-year follow-up. Two studies with corticosteroids reported mixed findings with no beneficial effect beyond 14 weeks of follow-up. One study assessing platelet-rich plasma found no significant improvement in OA-BMLs at 12 months follow-up. Knee pain was improved in two studies evaluating TissueGene-C and one study assessing APS; the remaining studies found no improvement in knee pain. Overall, we found mixed evidence on the efficacy of intra-articular therapy for improving OA-BMLs in KOA. Additional studies with long-term follow-up are needed to confirm the effect of various intra-articular therapies on OA-BMLs in KOA.
ER  -

KLEINSCHMIDT, A. C., A. SINGH, Mohammad Salman HUSSAIN, G. A. LOVELL and A. W. SHEE. How Effective Are Non-Operative Intra-Articular Treatments for Bone Marrow Lesions in Knee Osteoarthritis in Adults? A Systematic Review of Controlled Clinical Trials. \textit{Pharmaceuticals}. Basel: MDPI, 2022, vol.~15, No~12, p.~1-17. ISSN~1424-8247. Available from: https://dx.doi.org/10.3390/ph15121555.

Detailed Information on Publication Record