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@article{2240870,
author = {Cairo Calzada, Albert and Vargová, Anna and Shukla, Neha and Capitao, Claudio and Mikulková, Pavlína and Valuchová, Soňa and Pečinková, Jana and Bulankova, Petra and Říha, Karel},
article_location = {WASHINGTON},
article_number = {6606},
doi = {http://dx.doi.org/10.1126/science.abo0904},
keywords = {MESSENGER-RNA DECAY; SMG7; PROGRAM; PROTEIN; MEIOSIS; REVEALS;BODIES},
language = {eng},
issn = {0036-8075},
journal = {Science},
title = {Meiotic exit in Arabidopsis is driven by P-body-mediated inhibition of translation},
url = {https://www.science.org/doi/10.1126/science.abo0904},
volume = {377},
year = {2022}
}
TY - JOUR
ID - 2240870
AU - Cairo Calzada, Albert - Vargová, Anna - Shukla, Neha - Capitao, Claudio - Mikulková, Pavlína - Valuchová, Soňa - Pečinková, Jana - Bulankova, Petra - Říha, Karel
PY - 2022
TI - Meiotic exit in Arabidopsis is driven by P-body-mediated inhibition of translation
JF - Science
VL - 377
IS - 6606
SP - 629-634
EP - 629-634
PB - AMER ASSOC ADVANCEMENT SCIENCE
SN - 00368075
KW - MESSENGER-RNA DECAY
KW - SMG7
KW - PROGRAM
KW - PROTEIN
KW - MEIOSIS
KW - REVEALS;BODIES
UR - https://www.science.org/doi/10.1126/science.abo0904
N2 - Meiosis, at the transition between diploid and haploid life cycle phases, is accompanied by reprograming of cell division machinery and followed by a transition back to mitosis. We show that, in Arabidopsis, this transition is driven by inhibition of translation, achieved by a mechanism that involves processing bodies (P-bodies). During the second meiotic division, the meiosis-specific protein THREE-DIVISION MUTANT 1 (TDM1) is incorporated into P-bodies through interaction with SUPPRESSOR WITH MORPHOGENETIC EFFECTS ON GENITALIA 7 (SMG7). TDM1 attracts eIF4F, the main translation initiation complex, temporarily sequestering it in P-bodies and inhibiting translation. The failure of tdm1 mutants to terminate meiosis can be overcome by chemical inhibition of translation. We propose that TDM1-containing P-bodies down-regulate expression of meiotic transcripts to facilitate transition of cell fates to postmeiotic gametophyte differentiation.
ER -
CAIRO CALZADA, Albert, Anna VARGOVÁ, Neha SHUKLA, Claudio CAPITAO, Pavlína MIKULKOVÁ, Soňa VALUCHOVÁ, Jana PEČINKOVÁ, Petra BULANKOVA and Karel ŘÍHA. Meiotic exit in Arabidopsis is driven by P-body-mediated inhibition of translation. \textit{Science}. WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE, 2022, vol.~377, No~6606, p.~629-634. ISSN~0036-8075. Available from: https://dx.doi.org/10.1126/science.abo0904.
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