Meiotic exit in Arabidopsis is driven by P-body-mediated
inhibition of translation

J 2022

Meiotic exit in Arabidopsis is driven by P-body-mediated inhibition of translation

CAIRO CALZADA, Albert, Anna VARGOVÁ, Neha SHUKLA, Claudio CAPITAO, Pavlína MIKULKOVÁ et. al.

Basic information

Original name

Meiotic exit in Arabidopsis is driven by P-body-mediated inhibition of translation

Authors

CAIRO CALZADA, Albert (724 Spain, belonging to the institution), Anna VARGOVÁ (703 Slovakia, belonging to the institution), Neha SHUKLA (356 India, belonging to the institution), Claudio CAPITAO, Pavlína MIKULKOVÁ (203 Czech Republic, belonging to the institution), Soňa VALUCHOVÁ (703 Slovakia, belonging to the institution), Jana PEČINKOVÁ (203 Czech Republic, belonging to the institution), Petra BULANKOVA and Karel ŘÍHA (203 Czech Republic, guarantor, belonging to the institution)

Edition

Science, WASHINGTON, AMER ASSOC ADVANCEMENT SCIENCE, 2022, 0036-8075

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10608 Biochemistry and molecular biology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 56.900

RIV identification code

RIV/00216224:14740/22:00127511

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1126/science.abo0904

UT WoS

000837874700039

Keywords in English

MESSENGER-RNA DECAY; SMG7; PROGRAM; PROTEIN; MEIOSIS; REVEALS;BODIES

Abstract

V originále

Meiosis, at the transition between diploid and haploid life cycle phases, is accompanied by reprograming of cell division machinery and followed by a transition back to mitosis. We show that, in Arabidopsis, this transition is driven by inhibition of translation, achieved by a mechanism that involves processing bodies (P-bodies). During the second meiotic division, the meiosis-specific protein THREE-DIVISION MUTANT 1 (TDM1) is incorporated into P-bodies through interaction with SUPPRESSOR WITH MORPHOGENETIC EFFECTS ON GENITALIA 7 (SMG7). TDM1 attracts eIF4F, the main translation initiation complex, temporarily sequestering it in P-bodies and inhibiting translation. The failure of tdm1 mutants to terminate meiosis can be overcome by chemical inhibition of translation. We propose that TDM1-containing P-bodies down-regulate expression of meiotic transcripts to facilitate transition of cell fates to postmeiotic gametophyte differentiation.

Links

EF15_003/0000479, research and development project

Name: Regulace rostlinné meiózy

90129, large research infrastructures

Name: Czech-BioImaging II

Citovat

CAIRO CALZADA, Albert, Anna VARGOVÁ, Neha SHUKLA, Claudio CAPITAO, Pavlína MIKULKOVÁ, Soňa VALUCHOVÁ, Jana PEČINKOVÁ, Petra BULANKOVA and Karel ŘÍHA. Meiotic exit in Arabidopsis is driven by P-body-mediated inhibition of translation. Science. WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE, 2022, vol. 377, No 6606, p. 629-634. ISSN 0036-8075. Available from: https://dx.doi.org/10.1126/science.abo0904.

@article{2240870,
   author = {Cairo Calzada, Albert and Vargová, Anna and Shukla, Neha and Capitao, Claudio and Mikulková, Pavlína and Valuchová, Soňa and Pečinková, Jana and Bulankova, Petra and Říha, Karel},
   article_location = {WASHINGTON},
   article_number = {6606},
   doi = {http://dx.doi.org/10.1126/science.abo0904},
   keywords = {MESSENGER-RNA DECAY; SMG7; PROGRAM; PROTEIN; MEIOSIS; REVEALS;BODIES},
   language = {eng},
   issn = {0036-8075},
   journal = {Science},
   title = {Meiotic exit in Arabidopsis is driven by P-body-mediated inhibition of translation},
   url = {https://www.science.org/doi/10.1126/science.abo0904},
   volume = {377},
   year = {2022}
}

TY  - JOUR
ID  - 2240870
AU  - Cairo Calzada, Albert - Vargová, Anna - Shukla, Neha - Capitao, Claudio - Mikulková, Pavlína - Valuchová, Soňa - Pečinková, Jana - Bulankova, Petra - Říha, Karel
PY  - 2022
TI  - Meiotic exit in Arabidopsis is driven by P-body-mediated inhibition of translation
JF  - Science
VL  - 377
IS  - 6606
SP  - 629-634
EP  - 629-634
PB  - AMER ASSOC ADVANCEMENT SCIENCE
SN  - 00368075
KW  - MESSENGER-RNA DECAY
KW  - SMG7
KW  - PROGRAM
KW  - PROTEIN
KW  - MEIOSIS
KW  - REVEALS;BODIES
UR  - https://www.science.org/doi/10.1126/science.abo0904
N2  - Meiosis, at the transition between diploid and haploid life cycle phases, is accompanied by reprograming of cell division machinery and followed by a transition back to mitosis. We show that, in Arabidopsis, this transition is driven by inhibition of translation, achieved by a mechanism that involves processing bodies (P-bodies). During the second meiotic division, the meiosis-specific protein THREE-DIVISION MUTANT 1 (TDM1) is incorporated into P-bodies through interaction with SUPPRESSOR WITH MORPHOGENETIC EFFECTS ON GENITALIA 7 (SMG7). TDM1 attracts eIF4F, the main translation initiation complex, temporarily sequestering it in P-bodies and inhibiting translation. The failure of tdm1 mutants to terminate meiosis can be overcome by chemical inhibition of translation. We propose that TDM1-containing P-bodies down-regulate expression of meiotic transcripts to facilitate transition of cell fates to postmeiotic gametophyte differentiation.
ER  -

CAIRO CALZADA, Albert, Anna VARGOVÁ, Neha SHUKLA, Claudio CAPITAO, Pavlína MIKULKOVÁ, Soňa VALUCHOVÁ, Jana PEČINKOVÁ, Petra BULANKOVA and Karel ŘÍHA. Meiotic exit in Arabidopsis is driven by P-body-mediated inhibition of translation. \textit{Science}. WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE, 2022, vol.~377, No~6606, p.~629-634. ISSN~0036-8075. Available from: https://dx.doi.org/10.1126/science.abo0904.

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