Blood-Brain Barrier Alterations and Edema Formation in Different Brain Mass Lesions

@article{2242906,
   author = {Solár, Peter and Hendrych, Michal and Barák, Martin and Valeková, Hana and Hermanová, Markéta and Jančálek, Radim},
   article_location = {Lausanne, Switzerland},
   article_number = {July 2022},
   doi = {http://dx.doi.org/10.3389/fncel.2022.922181},
   keywords = {blood-brain barrier; glioblastoma multiforme; brain edema; brain metastasis; brain lymphoma; brain abscess},
   language = {eng},
   issn = {1662-5102},
   journal = {Frontiers in Cellular Neuroscience},
   title = {Blood-Brain Barrier Alterations and Edema Formation in Different Brain Mass Lesions},
   url = {https://www.frontiersin.org/articles/10.3389/fncel.2022.922181/full},
   volume = {16},
   year = {2022}
}

TY  - JOUR
ID  - 2242906
AU  - Solár, Peter - Hendrych, Michal - Barák, Martin - Valeková, Hana - Hermanová, Markéta - Jančálek, Radim
PY  - 2022
TI  - Blood-Brain Barrier Alterations and Edema Formation in Different Brain Mass Lesions
JF  - Frontiers in Cellular Neuroscience
VL  - 16
IS  - July 2022
SP  - 1-20
EP  - 1-20
PB  - Frontiers
SN  - 16625102
KW  - blood-brain barrier
KW  - glioblastoma multiforme
KW  - brain edema
KW  - brain metastasis
KW  - brain lymphoma
KW  - brain abscess
UR  - https://www.frontiersin.org/articles/10.3389/fncel.2022.922181/full
N2  - Differential diagnosis of brain lesion pathologies is complex, but it is nevertheless crucial for appropriate clinical management. Advanced imaging methods, including diffusion-weighted imaging and apparent diffusion coefficient, can help discriminate between brain mass lesions such as glioblastoma, brain metastasis, brain abscesses as well as brain lymphomas. These pathologies are characterized by blood-brain barrier alterations and have been extensively studied. However, the changes in the blood-brain barrier that are observed around brain pathologies and that contribute to the development of vasogenic brain edema are not well described. Some infiltrative brain pathologies such as glioblastoma are characterized by glioma cell infiltration in the brain tissue around the tumor mass and thus affect the nature of the vasogenic edema. Interestingly, a common feature of primary and secondary brain tumors or tumor-like brain lesions characterized by vasogenic brain edema is the formation of various molecules that lead to alterations of tight junctions and result in blood-brain barrier damage. The resulting vasogenic edema, especially blood-brain barrier disruption, can be visualized using advanced magnetic resonance imaging techniques, such as diffusion-weighted imaging and apparent diffusion coefficient. This review presents a comprehensive overview of blood-brain barrier changes contributing to the development of vasogenic brain edema around glioblastoma, brain metastases, lymphomas, and abscesses.
ER  - 

SOLÁR, Peter, Michal HENDRYCH, Martin BARÁK, Hana VALEKOVÁ, Markéta HERMANOVÁ and Radim JANČÁLEK. Blood-Brain Barrier Alterations and Edema Formation in Different Brain Mass Lesions. \textit{Frontiers in Cellular Neuroscience}. Lausanne, Switzerland: Frontiers, 2022, vol.~16, July 2022, p.~1-20. ISSN~1662-5102. Available from: https://dx.doi.org/10.3389/fncel.2022.922181.